Soybean is a food crop with a source of vegetable protein, in Indonesia the use of soybeans is used for the food and feed industry. The Anjasmoro variety is a variety that is in great demand by farmers in East Java because it has high production, large seed size and the pods are not easily broken. The development of soybean cultivation as an intensification effort has experienced many obstacles, one of which is drought stress. Environmental conditions with limited water availability inhibit the growth of soybean plants. This study aims to determine how the effect of giving Rhizobium on the growth and production of soybean (Glycine max.L) Anjasmoro variety. This research was conducted from March to June 2020 in the village of Antirogo Jember. The design used in this study was non-factorial RAK with 5 treatments, namely without rhizobium, 5 grams/l, 10 grams/l, 15 grams/l, and 20 grams/l. The results showed that the administration of rhizobium showed significantly different effects on plant height, root length, root dry weight, shoot dry weight, root nodule number, root nodule weight, number of pods, number of pithy pods, pod weight, and seed dry weight. Giving Rhizobium concentration of 20 grams/l gave the highest average yield of 2.6 tons/ha.