Objectives: to investigate the flexural strength of three materials commonly used for interim implant-supported fixed complete dentures (ISFCDs): conventional heat cure PMMA, CAD/CAM milled PMMA, and carbon fiber-reinforced PMMA. Methods: Sixty specimens (n=60) divided equally into three groups (heat cure, milled, carbon fiber) were prepared. Samples were inspected to ensure absence of voids or irregularities and when required, minor adjustments were made to adjust the dimensions. The samples underwent thermocycling (5-55°C for 2500 cycles) and were then tested using a three-point bend test. Results: There was a statistically significant difference between heat cure PMMA and carbon fiber PMMA (p<0.001), between CAD-CAM resin and carbon fiber resin (p<0.001). There was no significant difference between CAD-CAM and conventional PMMA resin (p>0.05). Conclusions: as clinical implications, using carbon fiber is a viable treatment option for interim ISFCDs. Veneering the material with pink and white resin would improve the overall esthetics.