Pluronic L64 Research Articles

The water intake of grazing cows and its effect on the intake of “Pluronic L64” administered in the drinking water for the control of bloat

Abstract Studies of the use of the anti-foaming detergent “Pluronic” administered in the drinking water as a means of controlling bloat have been made using fixed concentrations. Under normal grazing conditions, where the material is added to the drinking water trough, the concentration will vary according to the level of water intake and also in each drinking period through continuous dilution by incoming water. The water intake of a herd of 80 cows in milk has been measured for a period of several weeks under various weather conditions in the early spring period, when bloat is prevalent These figures have been used to estimate the concentration changes taking place in the drinking water under conditions of continuous twice-daily dosing with “Pluronic”, and thus determine the average daily intake of the material over the period in question. The effect of variations in water intake and the possibilities of adjusting the dose rate according to weather and bloat conditions are considered.

The use of “pluronics” administered in the drinking water as a means of bloat control in cattle

Abstract Because of their anti-foaming properties the non-ionic surface active agents Pluronic L61, Pluronic L62, and Pluronic L64 (polyoxypropylene-polyoxyethylene block polymers) have been under study for some years as a means of preventing bloat in cattle. Field experience as early as 1955 indicated that Pluronic L62 was highly effective as a drench when mixed with water, and, provided cows were given time to become accustomed to the taste, appeared to be effective when administered via the drinking water trough at the rate of approximately 0.1 oz per cow twice a day. Field application of the more readily dispersed and milder tasting Pluronic L64 in the water troughs at the same rate of application eliminated losses from bloat in the No, 1 Dairy herd of 80 to 90 cows at Ruakura over a period of seven years. The material was used throughout the period when bloat could occur. More recently, the use of an untreated herd as controls on the No. 1 Dairy Farm which was grazed by the treated herd has...

Effects of surface active agents on the susceptibility of Swiss mice to Candida albicans.

The LD50's ofCandida albicans combined with Plurafac B26, Mulsor 224, Pluronic L62, and Polyethylene Glycol 400 Mono Laurate injected intraperitoneally into female white Swiss mice were calculated by the method ofReed &Muench. Each of the previously mentioned surface-active agent —Candida albicans combinations had a lower LD50 than theCandida albicans control.