Biodegradable interference fixation screws have gained wide acceptance since their introduction. The most common material used is poly L-lactide. Interference screws composed of a copolymer containing both dextro and levo isomers of lactide are now available, but lack clinical trails. Animal studies demonstrate more rapid degradation than pure PLLA and replacement of the screws with bone. Purpose: This study evaluated the clinical effectiveness and radiographic response of a new poly D, L lactide interference screw used for ACL reconstruction. Methods: A consecutive prospective series of patella tendon autograft ACL reconstructions was studied. All patients had both graft ends fixed with a poly D (2%) L (98%) lactide screw and were evaluated at 3, 6, 12, and 24 months and then annually thereafter. Inclusion criteria were unilateral knee instability with a positive Lachman and pivot shift tests, minimum age of 16 years with nearly closed knee growth plates, adequate bone density, a willingness to comply with the study protocol, and a commitment to return for at least two years follow-up. Exclusionary criteria included PCL tears, prior knee ligament surgery, or contralateral ACL injury. Preoperative and postoperative Tegner, Lysholm, ICDK activity scores, Lachman and pivot shift data were obtained. Postoperative KT and radiograph exams were done. Results: 59 patients met these criteria (40 male, 19 female), at an average follow-up of 19 months (range 12–36 months). The average postoperative Cincinnati score was 86 (46 preoperative), Tegner score was 6.5 (2.3 preoperative), Lysholm score was 89 (53 preoperative), and IKDC activity score was 3.3 out of 4 (1.6 preoperative). Only 1 patient had a postoperative Lachman test (+1) and there were no positive pivot shift tests. Only one KT manual maximum exam was >3 mm (4 mm). No adverse events were encountered during screw insertion and postoperative radiographs demonstrated very rapid consolidation of the bone plug and obliteration of the tunnels with bone in-growth. These changes were increasingly apparent at the 2 and 3 year point (significantly earlier than published reports using pure PLLA screws). Discussion: This is the first clinical report on the use of poly D (2%)L (98%) lactide interference fixation screws. This copolymer uses a zinc catalyst instead of the conventional tin making the polymer more hydrophilic. The addition of a “D” isomer also speeds the degradation process. These screws worked well clinically with no adverse events. Rapid graft tunnel obliteration was observed at two and three years, consistent with animal studies demonstrating a more rapid polymer absorption than seen with pure PLLA devices.