Platform Template Research Articles

Data analysis method for power big data

This paper discusses a data quality analysis and evaluation mode based on power big data. Its basic content is to use the analysis platform template to conduct acquisition control and process rule analysis, and then use the data quality management module to call out the platform database system that realizes the inspection and analysis function, and retrieve and generate inspection data from the entity base. The analysis program will classify, count, sort, and sort the data, The final generated quantitative indicator data reflecting the project implementation status and data quality will be saved in the analysis result table. The analysis result report called from the middle platform can obtain a more detailed data quality analysis and evaluation report reflecting the data quality of various quantitative projects. This paper has improved the intelligent degree of information quality management and evaluation, realized the intelligent control of information service quality, adapted to the needs of large-scale information service management, and completed the quantitative research and evaluation of information completeness, timeliness, accuracy, accuracy and other important parameters.

Organic contaminants: photocatalytic degradation using HHP/CuONPs (2D/3D) composite as a heterogeneous catalyst

ABSTRACT Human hair is a filament rich in protein that grows from the follicles present in the scalp. It is considered to be a notable biomaterial consisting of β-keratin, which shows excellent catalytic activity in organic transformation. Keratin is a family of structural fibrous proteins rich in cysteine, which are abundantly present in human hair. Based on the template synthesis strategy, human-hair Keratin was used as a platform template to synthesise metal oxide nanoparticles. Here the aim was to synthesis hair protein supported CuO nanoparticles (HHP/CuONPs) and study their catalytic applications. Protein is extracted from the hair sample using the Shindai method. The HHP/CuONPs sample has been scrutinised using various characterisation techniques such as UV, FT-IR, SEM, TEM, EDX, Raman, XPS, and zeta potential. The synthesised HHP/CuONPs show photo-catalytic efficiency against coloured organic pollutants, 2,4-Dinitrophenol (DNP), and amaranth dye. The degradation level has been found to be 96% in DNP and 94% in amaranth dye. Optimisation and reusability of hair protein-mediated copper oxide have been tested under various conditions.

A methodology for assessing and monitoring risk in the industrial wastewater sector

The concept of sustainable risk assessment in industrial wastewater treatment is vital to determine the causes and consequences of plant failure. The potential wastewater-related risks that could hamper the operation of the entire manufacturing facility are currently inadequately defined and under researched. This work proposes a framework that includes the comparison of literature and experimental data to quantify the impact of the significant process parameters on the critical process outputs. From the business perspective, managing and minimising risks will be possible when the number of impact parameters is low and the relationships between different parameters are clearly understood. The results show that even only the evaluation of technical risks can provide an assessment platform template for other risk types. Also, the structured and statistically analyzed data sets applied might be further used in the design and development of machine learning platforms algorithms to inform sustainable process outcomes adjusted for various geographical locations and human factors which significantly affect the industrial water sector globally.

Keratin-Templated Synthesis of Metallic Oxide Nanoparticles as MRI Contrast Agents and Drug Carriers.

Keratin is a family of cysteine-rich structural fibrous proteins abundantly present in skin and skin appendages. Inspired by the template synthesis strategy, in this work, keratin was utilized for the first time as a platform template to synthesize metallic oxide nanoparticles, such as MnO2 (MnNPs@Keratin) and Gd2O3 (GdNPs@Keratin), in a simple and environment-benign fashion. These nanoparticles possess good colloid stability and biocompatibility, high T1 relaxivity ( r1 value = 6.8 mM-1s-1 for MnNPs@Keratin and 7.8 mM-1s-1 for GdNPs@Keratin), and superior in vivo magnetic resonance imaging performance of tumor. Moreover, these keratin-templated nanoparticles have great potential as drug carriers with the capacity of redox-responsive drug release due to the existence of disulfide cross-linking in keratin coating. These results suggest that keratin can be a promising platform template for the development of metal-based nanoparticles for cancer diagnosis and therapy.

The 2012 London Olympics: innovations in ICT and social media marketing

The 2012 London Olympics was a technological and marketing watershed event in the history of live sport mega events. A case study of the 2012 London Olympics was used to demonstrate how effective management of innovations in (a) collaborative information and communication technology (ICT) and (b) social media marketing (SMM) ushered in a new platform template for live sport events worldwide. A review of the literature revealed four primary factors responsible: (1) the foresight, planning, due diligence, and management effectiveness of the Olympic Delivery Authority (ODA), London Organising Committee for the Olympic and Paralympic Games (LOCOG) and their technology partners; (2) the confluence of dramatically increased mobile device use and social media engagement by prosumers; (3) the willingness of sponsors, marketers, and global media enterprises to take risks with innovative media and SMM strategies; and (4) the enthusiasm and passion for sport of prosumers worldwide.

Enhancement of ICRP's Lung Deposition Model for Pathogenic Bioaerosols

Terrorist attacks using pathogenic bioaerosols pose a significant public-health threat. Modeling the risk associated with such attacks is valuable from the standpoint of disaster preparedness. To attain greater flexibility in bioterrorism risk modeling, we have developed an open-source lung deposition code based on the International Committee for Radiological Protection (ICRP) Publication 66 (ICRP 1994). This article describes modifications to ICRP's lung deposition model to fit the bioaerosol context and discusses the impact of exposure from a few monodisperse pathogenic toxins such as botulinum toxin, influenza virus, and Bacillus anthracis to infants and adults. As most existing commercial lung deposition codes are not open-source, this code provides users a platform template that can be modified to meet their needs.

Efficient communication support in predictable heterogeneous MPSoC designs for streaming applications

Streaming applications are an important class of applications in emerging embedded systems such as smart camera network, unmanned vehicles, and industrial printing. These applications are usually very computationally intensive and have real-time constraints. To meet the increasing demand for performance and efficiency in these applications, the use of application specific IP cores in heterogeneous Multi-Processor System-on-Chips (MPSoCs) becomes inevitable. However, two of the key challenges in integrating these IP cores into MPSoCs are (i) how to properly handle inter-core communication; (ii) how to map streaming applications in an efficient and predictable way. In this paper, we first present a predictable high-performance communication assist (CA) that helps to tackle these design challenges. The proposed CA has zero throughput overhead, negligible latency overhead, and significantly less resource usage compared to existing CA designs. The proposed CA also provides a unified abstract interface for both processors and accelerator IP cores with flexible data access support. Based on the proposed CA design, we present a predictable heterogeneous multi-processor platform template for streaming applications. The template is used in a predictable design flow that uses Synchronous Data Flow (SDF) graphs for design time analysis. An accurate SDF model of our CA is introduced, enabling the mapping of applications onto heterogeneous MPSoCs in an efficient and predictable way. As a case study, we map the complete high-speed vision processing pipeline of an industrial application, Organic Light Emitting Diode (OLED) screen printing, onto one instance of the proposed platform. The result demonstrates that system design and analysis effort is greatly reduced with the proposed CA-based design flow.

Design of an Automated Enhanced-Throughput Platform for Functional Characterization of Positive Allosteric Modulator-Induced Leftward Shifts in Apparent Agonist Potency In Vitro

Prosecution of positive allosteric modulator (PAM) targets demands a specialized assay toolset. Many GPCR or ion channel targets are adaptable to functional assays whereby PAM efficacy can be inferred from left or rightward shifts in the concentration-response curves of orthosteric agonist. The inherent emphasis on throughput and occasional paucity of radioligands for a diverse array of allosteric modulator targets yields a need for an enhanced throughput agonist potency shift assay. Here, we describe a process by which such an assay was automated with robust, reproducible in vitro pharmacology. In direct comparison with a manual CRC shift assay, the enhanced throughput automated platform described here delivered near identical rank orders (r(2) = 0.75) at ~4-fold throughput/assay iteration. Correspondingly, average cycle time/plate decreased from 104 to 72 minutes. We also observed reductions in assay interference associated with compounds exhibiting ago-allosterism, which we attribute to preread compound incubation periods which are more precisely time-constrained under automation control. By leveraging automated laboratory technology, we have achieved meaningful throughput with no sacrifice of precision. Rather than to be target-class specific, the present process was specifically designed to serve as a platform template for a variety of cell-based functional allosteric modulation assays.

A Human Single Chain Transbody Specific to Matrix Protein (M1) Interferes with the Replication of Influenza A Virus

A cell penetrating format of human single chain antibody (HuScFv) specific to matrix protein (M1) of influenza A virus was produced by molecular linking of the gene sequence encoding the HuScFv (huscfv) to a protein transduction domain, i.e., penetratin (PEN) of the Drosophila homeodomain. DNA of a recombinant phagemid vector carrying the huscfv was used as a platform template in a three-step PCR for generating a nucleotide sequence encoding a 16 amino acid PEN peptide. The PEN-HuScFv had negligible cytotoxicity on living MDCK cells. They were readily translocated across the cell membrane and bound to native M1 in the A/H5N1-infected cells as revealed by immunofluorescent confocal microscopy. The PEN-HuScFv, when used to treat the influenza virus infected cells, reduced the number of viruses released from the cells. In conclusion, the cell penetrating M1-specific HuScFv, a transbody, produced in this study affected the influenza A virus life cycle in living mammalian cells. While the molecular mechanisms of the PEN-HuScFv need more investigation, the reagent warrants further testing in animals before developing it into a human immunotherapeutic anti-influenza formula.

Design exploration and automatic generation of MPSoC platform TLMs from Kahn Process Network applications

With increasingly more complex Multi-Processor Systems on Chip (MPSoC) and shortening time-to-market projections, Transaction Level Modeling and Platform Aware Design are seen as promising >approaches to efficient MPSoC design. In this paper, we present an automatized 3-phase process of Platform Aware Design and apply it to Kahn Process Networks (KPN) applications, a widely used model of computation for data-flow applications. We start with the KPN application and an abstract platform template and automatically generate an executable TLM with estimated timing that accurately reflects the system platform. We support homogeneous and heterogeneous multi-master platform models with shared memory or direct communication paradigm. The communication in heterogeneous platform modules is enabled with the transducer unit (TX) for protocol translation. TX units also act as message routers to support Network on Chip (NoC) communication. We evaluate our approach with the case study of the H.264 Encoder design process, in which the specification compliant design was reached from the KPN application in less than 2 hours. The example demonstrates that automatic generation of platform aware TLMs enables a fast, efficient and error resilient design process.

CoMPSoC

A growing number of applications, often with firm or soft real-time requirements, are integrated on the same System on Chip, in the form of either hardware or software intellectual property. The applications are started and stopped at run time, creating different use-cases. Resources, such as interconnects and memories, are shared between different applications, both within and between use-cases, to reduce silicon cost and power consumption. The functional and temporal behaviour of the applications is verified by simulation and formal methods. Traditionally, designers resort to monolithic verification of the system as whole, since the applications interfere in shared resources, and thus affect each other's behaviour. Due to interference between applications, the integration and verification complexity grows exponentially in the number of applications, and the task to verify correct behaviour of concurrent applications is on the system designer rather than the application designers. In this work, we propose a Composable and Predictable Multi-Processor System on Chip (CoMPSoC) platform template. This scalable hardware and software template removes all interference between applications through resource reservations. We demonstrate how this enables a divide-and-conquer design strategy, where all applications, potentially using different programming models and communication paradigms, are developed and verified independently of one another. Performance is analyzed per application, using state-of-the-art dataflow techniques or simulation, depending on the requirements of the application. These results still apply when the applications are integrated onto the platform, thus separating system-level design and application design.

Novel use of a custom stereotactic frame for placement of depth electrodes for epilepsy monitoring

The authors describe the first reported application of a miniature, customized, one-time use, skull-mounted stereotactic frame for the implantation of depth electrodes for epilepsy monitoring. Using a platform template, 4 skull fiducial markers were placed 1 week prior to surgery. A brain MR image and a CT scan were subsequently obtained. All planning (longitudinal trajectories into the hippocampi) was done preoperatively using personal computers in the office. No further workstation planning was necessary on the day of the operation. The StarFix microTargeting Platform system was secured to the previously implanted skull fiducial screws. Pin fixation was not required. The platform was used to identify the area of entry for the depth electrodes on the right and left sides. On each side, a 12-contact depth electrode was advanced to the depth of the targets without difficulty. A temporal craniotomy was then performed to place subdural electrodes. The desired location of the electrodes was confirmed on postoperative imaging studies. There were no complications associated with the electrode implantation. The depth electrodes demonstrated symmetrical, robust coverage of each hippocampus, with epileptiform discharges observed bilaterally. This first application of the StarFix platform for placing depth electrodes for epilepsy monitoring was both safe and feasible. With this technique, the patient does not need to be pinned or placed in a head holder, no imaging or computer planning is required on the day of implantation (which means there is no time pressure when the meticulous target/trajectory planning is done), and with bilateral posterior implants both bur holes can be made simultaneously. For these reasons this system may be preferable to existing methods of depth electrode implantation.

Bumper-Pile Design for Mating Platform and Subsea Drilling Template

Summary This paper describes the procedures used to design bumper piles for the docking installation of a large North Sea platform jacket over a subsea drilling template. Model tests are described and their response data presented and interpreted for design use. Procedures are presented for evaluating ultimate load- and energy-absorbing capacities of the docking piles together with the jacket-bottom horizontal framing. Conclusions are drawn and observations offered concerning analytical methods for determining docking pile design loads and the feasibility of mating large platform assemblies offshore.

A block localizer for easy and reproducible transfer of shielding block positions from simulator to treatment unit

For the localization of shielding blocks at the simulator a special tray called "block localizer" was constructed. It can be attached to the simulator head by means of magnets in the top frame. The "block localizer" provides a platform at a distance from the X-ray source corresponding to the source-to-block distance at the treatment unit. On the platform templates made from 0.5 mm brass to the size of the block bases can be positioned under fluoroscopy. Before taking the beam localization exposure a low sensitivity film is placed in a slit in the platform. On this film the template (block) position is recorded. For treatment the developed film is attached to the block tray and the shielding block inserted according to the light shadow of the template projected from the film onto the patient. An easy and reliable positioning of blocks during repeated irradiations is thus provided. The block (template) position is also recorded on the beam localization film of the patient as a transparent shadow.