In this work, we introduce Basilisk, a high-level architectural pattern designed to facilitate interoperability among various languages, platforms, and ecosystems. The pursuit of language-independent software development is highly desirable, enabling developers to utilize existing software products with most programming languages. Achieving platform independence is equally advantageous, allowing code deployment on different platforms effortlessly. While the development community has often aimed for either language or platform independence, Basilisk aims to combine both into a single product. To realize this dual objective, Basilisk employs two fundamental components. The first is a transpilation infrastructure used to render software products language-independent. The second is an abstraction layer over platforms, enabling the creation of platform-independent software products. To illustrate Basilisk’s potential, we introduce Hydra, a one-to-many, declarative transpilation infrastructure. Hydra has been utilized to develop transpilers from HydraKernel (source language) to various target languages, including D, C++, C#, Scala, Ruby, Hy, and Python. Additionally, we instantiate the abstraction layer in Wyvern, a low-level embedded domain-specific language for GPU programming, supporting any Vulkan-compatible GPU. With the Hydra transpilation infrastructure, Wyvern becomes available for D, C++, C#, Scala, Ruby, Hy, and Python. We evaluate Basilisk through the instantiation of Hydra and Wyvern, writing five algorithms from the Rodinia suite for the seven available languages, totaling 35 benchmarks. These benchmarks are executed on four different hardware platforms.