Plastic Materials Research Articles

Biodegradable chitosan hydrogel film incorporated with polyvinyl alcohol, chitooligosaccharides, and gallic acid for potential application in food packaging

The food and beverage industry worldwide is trying to switch to using environment-friendly and bio-degradable materials in food packaging to avoid environmental concerns of using petroleum-derived plastic (synthetic polymers) materials. In this study, chitosan (CH) hydrogel films were fabricated by using its derivative chitooligosaccharides (COS) as an additive, polyvinyl alcohol as a plasticiser, and bioactive gallic acid as a cross-linker. The physical, mechanical, structural, barrier (e.g., moisture, water vapour permeability (WVP), and UV-barrier property), thermal properties, and biodegradation patterns of fabricated films were investigated. The use of bio–composite in CH films exhibited a synergistic effect. A film with a homogenous/smooth surface and excellent mechanical and thermal properties was obtained. Additionally, incorporating COS and gallic acid reduced the moisture content, WVP, and transparency. Moreover, the films exhibited good colour, strong UV-barrier properties, and good biodegradable capacity in soil. The results suggest that eco-friendly CH hydrogel films have promising potential to be used in food packaging.

Life Cycle Analysis Study of Plastic Flower Pot Products

Some flower pots are made of plastic materials. Plastic waste is a global environmental issue with varying quantities and types in different countries. One source of plastic pollution is low-durability plastic pots, commonly used for seeding in agriculture, horticulture, and forestry. Waste from these plastic pots is difficult to decompose by soil microbes, thus posing an environmental contamination risk. Life Cycle Analysis (LCA), also known as life cycle assessment, is a method to measure the environmental impacts of products, such as biofuels. In LCA, researchers prepare an inventory of the resources used (e.g., fossil fuels and raw materials) and substances produced (e.g., greenhouse gases, solid waste, and other pollutants) throughout the full life cycle of production, transportation, and use of the product in question. From this inventory, researchers conduct impact assessments that estimate the final effects on human health, ecosystem function, and depletion of natural resources. This study aims to assess the life cycle analysis of plastic flower pot products from their initial material stage to their disposal as waste, in order to gain insights into the potential for minimizing their environmental impact. The results of research where the production of 600 ml plastic flower pot bottles required 28 grams of plastic resin per bottle, as well as energy for the production and transportation processes. Plastic packaging production produces defective products.

Clarification of the plastic deformations zone borders for the fuel tank diaphragm

A relevant area of theoretical and practical research in the field of rocket science is ensuring the uninterrupted and reliable operation for liquid rocket engines. Reliable operation and engine start in zero gravity is impossible without guaranteed separation of the liquid and gas phases in the fuel tank. This problem is solved by the introduction of metallic reversible diaphragm separators. The eversion process research for the metal diaphragm separators allows you to design them for fuel tanks of various sizes and shapes according to the specified parameters of the displacement of the component. This is an actual object of research. The known mathematical dependencies do not have sufficient accuracy and correspondence to experi- mental results. To improve the quality of design when using any deformation-energy approach, it is necessary to increase the accuracy of determining the boundaries for plastic deformation zone of diaphragms at various stages of eversion. Clarification of the boundaries for this zone is possible using modern computer modeling tools. The article provides a descriptions and simulation result for metal diaphragms with different geometric parameters, loaded with uniform pressure, taking into account the plastic material properties in the MSC NASTRAN software package. As a result of the work, a refined zone of plastic deformation for fuel tanks metal eversible diaphragms was determined. We have introduced new angles to describe this zone. The dependences for these angles on the angle of the torus region, independent of the geometric parameters of the diaphragm, were obtained. We also identified the conditions under which the use of the energy principle equation is inappropriate due to the presence of membrane stresses.

Microplastics meet micropollutants in a central european river stream: Adsorption of pollutants to microplastics under environmentally relevant conditions

Microplastics have emerged as pervasive pollutants in aquatic environments, and their interaction with organic contaminants poses a significant environmental challenge. This study aimed to explore the adsorption of micropollutants onto microplastics in a river, examining different plastic materials and the effect of aging on adsorption capacity. Microplastics (low-density polyethylene (LDPE), polyethylene terephthalate (PET), and polyvinyl chloride (PVC)) were introduced into a river stream, and a comprehensive analysis involving 297 organic pollutants was conducted. Passive samplers were deployed to monitor micropollutant presence in the river. Sixty-four analytes were identified in the river flow, with telmisartan being the most prevalent. Nonaged PVC showed the highest telmisartan concentration at 279 ng/g (168 ng/m2 regarding the microplastic surface), while aged PVC exhibited a fourfold decrease. Conversely, aged LDPE preferentially adsorbed metoprolol and tramadol, with concentrations increasing 12- and 3-fold, respectively, compared to nonaged LDPE. Azithromycin and clarithromycin, positively charged compounds, exhibited higher sorption to PET microplastics, regardless of aging. Diclofenac showed higher concentrations on nonaged PVC compared to aged PVC. Aging induced structural changes in microplastics, including color alterations, smaller particle production, and increased specific surface area. These changes influenced micropollutant adsorption, with hydrophobicity, dissociation constants, and the ionic form of pollutants being key factors. Aged microplastics generally showed different sorption properties. A comparison of microplastics and control sand particles indicated preferential micropollutant sorption to microplastics, underscoring their role as vectors for contaminant transport in aquatic ecosystems. Analysis of river sediment emphasized the significance of contact time in pollutant accumulation. Overall, this study provides insights into the complex interactions between microplastics and organic pollutants under environmental conditions and contributes to a better understanding of the fate and behavior of these two types of contaminants in aquatic ecosystems.

Research on computationally generative design of woven braced structure based on fiber composite material in architectural design industry

ABSTRACT With the intervention of computer algorithm-assisted design in the realm of contemporary architectural design, architectural spatial forms and corresponding design methods have improved significantly. However, the limitations of material strength and plasticity impose certain constraints on the architectural design of the new century. Based on this occurrence, this paper studies the development of a computational generative design system for woven braced structure composed of fiber-reinforced materials. Through experimental data of material performance, the research firstly argues feasibility of employing fiber composite materials to braced structure. The conclusion is that the structure designed and generated could produce a support of 1 ton per ㎡. Moreover, based on the ant colony algorithm and the algorithm principle of cellular automata on the Java platform, the study designs a generative system with iterative computing of force as the major axis to achieve the self-organization and adaptability of the braced structure. Above all, this paper proposes a design strategy engaging with computational generative design approach, as well as a design attempt for the material and form of architecture.

Esophagoplasty Using a Jejunum Segment on a Vascular Pedicle

Aim: to substantiate the expediency of using a segment of the jejunum on a vascular pedicle in esophagoplasty. Materials and methods. At the National Medical Research Center of Surgery named after A.V. Vishnevsky, 12 patients underwent esophagoplasty with a combined visceral transplant, of which 9 (75.0 %) received a gastrointestinal graft and 3 (25.0 %) — a colon-jejunum one. Esophagectomy with simultaneous esophageal plastic surgery was performed in 10 (83.3 %) patients, in 4 (40 %) of them — in combination with distal gastric resection. The indication for surgery in 3 patients was cicatricial stricture of the esophagus and stenosis of the pylorus, in 2 — achalasia of the cardia of the terminal stage (in one patient — with ulcerative stenosis of the pylorus). Three more patients underwent esophagectomy due to peptic strictures: esophagogastroanastomosis (n = 1), esophagoenteroanastomosis (n = 1) and esophagus after Nissen surgery (n = 1). Cancer recurrence after proximal gastric resection and gastrectomy in 2 patients was an indication for esophagectomy. Also, 2 (16.7 %) patients were hospitalized in the National Medical Research Center of Surgery named after A.V. Vishnevsky with incomplete esophagoplasty: one person — after Dobromyslov — Torek surgery for spontaneous rupture of the esophagus, and one patient — after the unsuccessful Lewis surgery for esophageal cancer performed in other hospitals. Results. The average duration of post-operative stay was 12.7 ± 6.3 days. The postoperative period was smooth in 10 (83.3 %) patients. The failure of the cervical anastomosis was revealed in 1 (8.3 %) patient on day 5 after esophageal plastic surgery with colon-jejunum graft, which was resolved conservatively without repeated surgery. Relaparotomy was required in one patient on day 7 after surgery for bile peritonitis, the cause of which was destructive acalculous cholecystitis with perforation. All 12 patients were discharged from the clinic with full nutrition through the mouth. In the long-term period, 11 (91.7 %) patients remained under observation, 1 (9.1 %) developed an esophagogastroanastomosis stricture 1.5 months after esophageal plastic surgery, which was resolved by 4 courses of bougation during the first 9 months after surgery. No other complications were noted. Conclusion. The segment of the jejunum on the vascular pedicle, used for esophagoplasty, in the condition of a shortage of plastic material, allows not only to complete the reconstruction at once, but also to restore the natural passage of food and prevent bile reflux.

Numerical and Theoretical Analyses of Laminated Veneer Lumber Beams Strengthened with Fiber-Reinforced Polymer Sheets

This study outlines a method of utilizing the finite element method and a simple mathematical model to predict the behavior of laminated veneer lumber (LVL) beams strengthened with composite sheets. The numerical models were created using the Abaqus 2017 software. The LVL was considered as a linearly elastic or elastic–plastic material, factoring in Hill’s yield criterion. The composites were simulated as linearly elastic–ideally plastic materials. The mathematical models were predicated on the methodology of transformed cross-section. The theoretical and numerical outcomes were juxtaposed with previous empirical investigations. The comparison encompassed load-bearing capacity, stiffness, and deformation under peak force. Furthermore, presentations of normal stress maps in the LVL and composite have been illustrated. The derived maps were juxtaposed with the delineations of failure modes. An adequate correlation was identified between the theoretical, numerical, and empirical values in the case of beams reinforced with aramid, glass, and carbon sheets. The relative deviation varied from several to multiple percentages. This technique is not applicable for evaluating load-bearing capacity and deformation when only dealing with sheets with low elongation of rupture. This is a consequence of their premature failure. The proposed models may be utilized by researchers and engineers in the design of reinforcements for timber structures.

Seismic Response and Collapse Analysis of a Transmission Tower Structure: Assessing the Impact of the Damage Accumulation Effect

This paper delves into the impact of the damage accumulation effect, which leads to the degradation of material strength and stiffness, on the seismic resistance of transmission towers. Building upon the elastic–plastic finite element theory, a mixed hardening constitutive model is derived for circular steel tubes, standard elements in transmission towers, incorporating the damage accumulation effect. A user material subroutine, UMAT, is created within the LS–DYNA framework. The program’s validity and reliability are established through axial constant–amplitude loading tests on single steel tubes. The subroutine is employed to conduct the incremental dynamic analysis (IDA) of an individual transmission tower and to contrast it with the structure utilizing the Plastic Kinematic material model, assessing the discrepancies in tower top displacements and segment damage indices (SDIs) at both macroscopic and microscopic scales. The results shows that the Plastic Kinematic model inflates the seismic performance of the transmission tower. When considering the damage accumulation effect in structural failure, the damage index of the members increases, leading to a reduction in both the structural strength and stiffness. The dynamic response in the plastic phase becomes more pronounced, and the onset of structural failure is accelerated. Consequently, structural analysis under seismic conditions should account for the damage accumulation process. Through the delineation of member and segment damage, the extent of damage to transmission tower segments can be quantitatively assessed. Subsequently, the ultimate load–bearing capacity and the most vulnerable location of the transmission tower can be ascertained. Finally, this paper provides a detailed analysis of the transmission tower collapse process under seismic action and summarizes the mechanism of collapse for the structure.

Welding load, temperature, and material flow in ultrasonic vibration enhanced friction stir lap welding of aluminum alloy to steel

To elucidate the effect of ultrasonic vibration on the welding process (welding load, thermal cycle, and material flow) of aluminum/steel dissimilar metals in friction stir lap welding, conventional friction stir lap welding (FSLW) and ultrasonic vibration enhanced friction stir lap welding (U-FSLW) were used to weld aluminum/steel dissimilar metals. The results indicate that applying ultrasonic vibration to the FSLW of aluminum/steel dissimilar metals can effectively decrease welding loads (tool torque, axial force, and spindle power), and it was found that the reduction in welding load was inversely proportional to the welding speed. The effect of additional ultrasonic vibration on axial force was the largest. Ultrasonic vibration had a significant preheating effect, and its thermal effect in the width and depth directions of the workpiece gradually weakened. Additional ultrasound can reduce the peak temperature during the welding process. The instantaneous state of the weld was obtained using the "emergency stop+emergency cooling" technology, and the three-dimensional visualization characterization of material flow near the keyhole was achieved using X-ray based computer tomography (CT). It was found that ultrasonic vibration could increase the material's plastic flow, change the steel structure's flow path, and significantly increase the steel particles' flow range near the pin tool. Compared with conventional FSLW, the changes in the macro/microstructure of U-FSLW joints were closely related to the welding thermal cycle and material flow.

Internalization of nano- and micro-plastics in human erythrocytes leads to oxidative stress and estrogen receptor-mediated cellular responses

Plastic material versatility has resulted in a substantial increase in its use in several sectors of our everyday lives. Consequently, concern regarding human exposure to nano-plastics (NPs) and micro-plastics (MPs) has recently increased. It has been shown that plastic particles entering the bloodstream may adhere to the erythrocyte surface and exert adverse effects following erythrocyte aggregation and adhesion to blood vessels. Here, we explored the effects of polystyrene nano-plastics (PS-NPs) and micro-plastics (PS-MPs) on human erythrocytes. Cellular morphology, binding/internalization of PS-NPs and PS-MPs, oxidative stress parameters, as well as the distribution and anion exchange capability of band 3 (anion exchanger 1; SLC4A1) have been analyzed in human erythrocytes exposed to 1 μg/mL PS-NPs or PS-MPs for 3 and 24 h, respectively. The data obtained showed significant modifications of the cellular shape after exposure to PS-NPs or PS-MPs. In particular, a significantly increased number of acanthocytes, echinocytes and leptocytes were detected. However, the percentage of eryptotic cells (<1 %) was comparable to physiological conditions. Analytical cytology and confocal microscopy showed that PS-NPs and PS-MPs bound to the erythrocyte plasma membrane, co-localized with estrogen receptors (Erα/ERβ), and were internalized. An increased trafficking from the cytosol to the erythrocyte plasma membrane and abnormal distribution of ERs were also observed, consistent with ERα-mediated binding and internalization of PS-NPs. An increased phosphorylation of ERK1/2 and AKT kinases indicated that an activation of the ER-modulated non-genomic pathway occurred following exposure to PS-NPs and PS-MPs. Interestingly, PS-NPs or PS-MPs caused a significant production of reactive oxygen species, resulting in an increased lipid peroxidation and protein sulfhydryl group oxidation. Oxidative stress was also associated with an altered band 3 ion transport activity and increased oxidized haemoglobin, which led to abnormal clustering of band 3 on the plasma membrane. Taken together, these findings identify cellular events following the internalization of PS-NPs or PS-MPs in human erythrocytes and contribute to elucidating potential oxidative stress-related harmful effects, which may affect erythrocyte and systemic homeostasis.

Preparation and properties of two types of tung oil‐based liquid auxiliary heat stabilizer for polyvinyl chloride processing

AbstractIn this work, two types of tung oil‐based auxiliary heat stabilizers (Ph‐T and Ph‐TO) were prepared for application in PVC processing. Combined with traditional heat stabilizers (calcium stearate and zinc stearate), Ph‐T or Ph‐TO can greatly alleviate “zinc burning” during the PVC processing which can significantly extend the processing time of PVC, so that improve the fault tolerance rate during PVC processing. Notably, the preparation process of Ph‐T and Ph‐TO is simple and does not require any heating, leading to reduced production costs and simplified manufacturing processes. Additionally, Ph‐T or Ph‐TO can enhance the plasticity of PVC, reducing the need for plasticizers and achieving multiple benefits with a single additive, which might be applicable in the production of blood bags or cable sheathing.Highlights Two types novel tung oil‐based liquid auxiliary heat stabilizer for PVC processing were prepared. The preparation process is simple and does not require any heating. These auxiliary heat stabilizers can greatly alleviate “zinc burning” during the PVC processing and which can significantly extend the processing time of PVC, improve the fault tolerance rate during PVC processing. These auxiliary heat stabilizers can improve the overall plasticity of the PVC material and achieving the multi‐effect.

Product classes characterization at micro-scale level applied to granular wastes fractions < 20 mm: a case-study

A product class characterization was requested on some plastic granular waste samples, already reduced in fine form with particles < 20 mm, derived from waste electrical wires and PC cables. The product class discrimination was worked out by visual characterization with the aid of optical stereomicroscopy and confirmation by electron scanning microscopy (SEM) and microanalysis. Characterization at a micro-scale level evidenced predominance of plastic materials with presence of metal wires, paper, textile and glass fibres at residual levels in the main fraction (0.5–4 mm). The fractions < 0.5 mm, when present, cannot easily be distinguished at sight and only approximate qualitative information can be extracted by SEM analysis. The described approach has been carried out effectively due to major shape and material differences between plastic particles and metal wires and other materials. However, this approach may not work in every case, or it may not lead to usable results with every type of waste.

Recent advances in research from plastic materials to microplastics

Recent advances in research from plastic materials to microplastics

Graph Neural Networks for Geometry Design in Plastic Regime

In this work, we extend MeshGraphNets to simulate collisions involving plastic material, previously limited to hyperelastic, addressing higher non-linearities and energy dissipation. While previous work estimated only the displacement field, our approach also resolves the complete tensor stress field, under different boundary conditions and geometries.

A Quasi Real-Time Evaluation of High-Resolution Mass Spectra of Complex Chlorinated Paraffin Mixtures and Their Transformation Products.

Chlorinated paraffins (CPs) are complex mixtures of polychlorinated n-alkanes with multiple carbon- (C-, nC = 9-30) and chlorine homologues (Cl-, nCl = 3-18). The mass spectrometric analysis of CPs is time-consuming and challenging, especially when interferences between CPs, their transformation products, or from the matrix are numerous. These analytical challenges and the lack of appropriate and accessible data evaluation tools are obstacles to their analysis. CP-Hunter is a web-based, open-access data processing platform for the automatic analysis of mass spectra of CPs and their transformation products. Extracts of two consumer plastic materials and sewage sludge were evaluated with CP-Hunter. C- and Cl-homologue distributions were obtained in quasi-real-time and the posterior calculated fingerprints were in agreement with the ones obtained by traditional methods. However, the data extraction and evaluation time were now reduced from several minutes to seconds. The implemented signal deconvolution method, i.e., to resolve mass spectrometric interferences, provides robust results, even when severe matrix effects are present. CP-Hunter facilitates the untargeted analysis of unknown products and the detection and elimination of false positive signals. Finally, data evaluation with CP-Hunter is performed locally without the transfer of data to external servers. The tool is safe, public, and accessible at https://cphunter.cheminfo.org/.

Surface-initiated rolling contact fatigue on a dent: Microstructural evolutions through failure mechanism

The indentation of bearing raceways frequently contributes to bearing failures, as in gearboxes. The dents act as surface stress raisers through the Rolling Contact Fatigue (RCF) cycles, leading to crack initiation and spalling. The microstructural evolution mechanism occurring is not completely understood. Hence, to enhance bearing lifetime, it is crucial to identify microstructural parameters that influence crack initiation and propagation. Therefore, this study presents a multi-scale characterization of martensitic 100Cr6 bearings before and after RCF. It includes SEM, SEM/FIB, EBSD, TKD and ACOM-ASTAR observations. It showed that, before RCF, the bearing raceway features a 0.5 µm thick surface layer consisting in refined martensite and spread primary carbides, resulting from finishing operations. After RCF, no further grain refinement was observed along the raceway, except beneath the dent shoulder where a material plastic flow, nano-grains and ultra-fine grains of martensite, and sheared and spread primary carbides were detected up to 1.4 µm deep. Below and up to 3 µm deep, a fine grain layer is observed. The martensite morphology, size and disorientation suggest that it undergoes refinement through continuous Dynamic Recrystallisation and twinning. Crack initiation was preferentially observed in the nano-grains layer, at primary carbides/matrix interfaces. Above the crack, another refined region is observed resulting from high deformation and stresses through crack propagation. Finally, even in severely deformed areas, nanosized retained austenite islands were detected, indicating that it is not completely transformed.

Microplastic polyethylene induced inner ear dysfunction in murine model

While the hazardous effects of microplastics (MPs) are increasingly reported, it remains uncertain if MPs induce inner ear dysfunction. Nonetheless, prevalence of inner ear dysfunction was observed across all age groups. In this study, we investigated whether MP polyethylene affect inner ear function in a murine model. To detect hearing loss and balance defect after polyethylene (PE) exposure, we evaluated hearing threshold levels, assessed cerebral glucose metabolism, conducted transcriptome analysis, and performed behavioral studies. C57BL/6 J mice (5-week-old) were grouped into control (n = 10) and PE-fed groups (n = 10). Mice were orally administered 100 ppm/100 μL (equivalent to 10 μg) of PE every day for 4 months. We identified the accumulation of PE in the cochlea and vestibular region. The fragmented PE in inner ear was 3.00 ± 0.38 µm in size; the administered PE concentration was 1.14 ± 1.06 mg/g. Fourier transform infrared spectrometry confirmed that the properties of the MP were identical with those of PE fed to the mice. Transcriptomic analysis showed up-regulation of PER1, NR4A3 and CEBPB at the PE exposed inner ear tissue and it was confirmed using qRT-PCR, western blotting, and immunofluorescence staining. We observed abnormalities in balance related behavior assessment in the PE group. Exposure to PE increased the hearing thresholds and decreased glucose metabolism in the bilateral lateral entorhinal cortex, right primary auditory cortex, and right secondary auditory cortex. We can conclude that PE exposure induced inner ear dysfunction such as hearing loss and balance disorder.

A Systematic Literature Review for Addressing Microplastic Fibre Pollution: Urgency and Opportunities

Microplastic fibre (MPF) pollution is a pressing concern that demands urgent attention. These tiny synthetic textile fibres can be found in various ecosystems, including water and air, and pose significant environmental risks. Despite their size (less than 5 mm), they can harm aquatic and terrestrial organisms and human health. Studies have demonstrated that these imperceptible pollutants can contaminate marine environments, thereby putting marine life at risk through ingestion and entanglement. Additionally, microplastic fibres can absorb toxins from the surrounding water, heightening their danger when consumed by aquatic organisms. Traces of MPFs have been identified in human food chains and organs. To effectively combat MPF pollution, it is crucial to understand how these fibres enter ecosystems and their sources. Primary sources include domestic laundry, where synthetic textile fibres are released into wastewater during washing. Other significant sources include industrial effluents, breakdown of plastic materials, and atmospheric deposition. Additionally, MPFs can be directly released into the environment by improperly disposing of consumer products containing these fibres, such as non-woven hygienic products. A comprehensive approach is necessary to address this pressing issue, including understanding the sources, pathways, and potential risks of MPFs. Immediate action is required to manage contamination and mitigate MPF pollution. This review paper provides a systematic literature analysis to help stakeholders prioritise efforts towards reducing MPFs. The key knowledge gaps identified include a lack of information regarding non-standardised test methodology and reporting units, and a lack of information on manufacturing processes and products, to increase understanding of life cycle impacts and real hotspots. Stakeholders urgently need collaborative efforts to address the systematic changes required to tackle this issue and address the proposed opportunities, including targeted government interventions and viable strategies for the industry sector to lead action.

A two-scale approach for assessing the role of defects in fatigue crack nucleation in metallic structures

Metal structures often exhibit macroscopic defects from which cracks can nucleate during cyclic loading. The current work presents a two-scale approach to enable the prediction of crack nucleation from such defects by taking into account local microstructure features. The geometrical description of the defect and associated non-homogeneous strain fields are modeled using a macroscale model which employs a continuum elastoplastic material model for cyclic deformation. The cyclic deformation of the microstructure near the defect is modeled using a mesoscale model which employs a crystal plasticity material model and uses multiple realizations to address the statistical microstructure variability. The boundary conditions of the mesoscale model are extracted from the macroscale model. By simulating the deformation of the microstructure using the strain fields near the defect and by introducing a fatigue indicator parameter for crack nucleation, along with the weakest-link based upscaling methodology, the developed approach enables the prediction of the distribution of crack nucleation life. The approach is used for analyzing different defects for crack nucleation by considering local grain orientations. The predictions are shown to not only capture phenomena such as scatter, size effects, etc. qualitatively, but also agree with a classical engineering approach and experimentally reported data sets quantitatively.

Nasal instillation of polystyrene nanoplastics induce lung injury via mitochondrial DNA release and activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-signaling cascade

Nanoplastics (NPs) are a common type of degraded plastic material associated with adverse health effects such as pulmonary injury. However, the molecular mechanism(s) underlying lung injury as caused by NPs remains uncertain. Thus, we herein investigated the pulmonary toxicity of NPs on RAW264.7 cells and C57BL/6 mice. Our in vitro study indicated that NPs induced oxidative stress, cell death, inflammation, and the activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-signaling pathway. Mice in our in vivo study displayed significant pulmonary fibrosis, inflammation, apoptosis, necrosis, and excessive double-stranded DNA release into serum and bronchoalveolar lavage fluid. Our mechanistic exploration uncovered cGAS-STING-signaling activation as the leading cause of NPs-induced pulmonary fibrosis. The current study opens an avenue toward elucidating the role of the cGAS-STING-signaling pathway in NPs-induced pulmonary injury.