Plastic Damage Research Articles

Path-Dependent Progressive Failure Analysis for 3D-Printed Continuous Carbon Fibre Reinforced Composites

In order to predict the damage behaviours of 3D-printed continuous carbon fibre (CCF) reinforced composites, when additional short carbon fibre (SCF) composite components are employed for continuous printing or special functionality, a novel path-dependent progressive failure (PDPF) numerical approach is developed. First, a progressive failure model using Hashin failure criteria with continuum damage mechanics to account for the damage initiation and evaluation of 3D-printed CCF reinforced polyamide (PA) composites is developed, based on actual fibre placement trajectories with physical measurements of 3D-printed CCF/PA constituents. Meanwhile, an elastic-plastic model is employed to predict the plastic damage behaviours of SCF/PA parts. Then, the accuracy of the PDPF model was validated so as to study 3D-printed CCF/PA composites with either negative Poisson’s ratio or high stiffness. The results demonstrate that the proposed PDPF model can achieve higher prediction accuracies in mechanical properties of these 3D-printed CCF/PA composites. Mechanism analyses show that the stress distribution is generally aggregated in the CCF areas along the fibre placement paths, and the shear damage and matrix tensile/compressive damage are the key damage modes. This study provides a new approach with valuable information for characterising complex 3D-printed continuous fibre-matrix composites with variable mechanical properties and multiple constituents.

Effects of random meso‐defects on fatigue behavior of welded joints: Damage evolution and lifetime prediction

AbstractRandom meso‐scale defects within welded joints can affect the structural damage process and cause dispersion in the fatigue lifetime of welded joints. In this paper, a meso‐scale stochastic damage approach is used to investigate the effect of random, meso‐scale defects on the fatigue damage lifetime of welded joints under different loads. First, we established an elastic–plastic fatigue damage model considering meso‐defects in the weld metal. Secondly, the fatigue lifetimes for gas tungsten arc welding and gas metal arc welding welded joints were predicted, with most of the predictions within the twofold dispersion factor. Thirdly, the Monte Carlo simulation method was used to investigate the influence of meso‐defect size on the fatigue lifetime dispersion degree, and the fatigue lifetime distribution under different loads was statistically analyzed.

Influence of steel slag as partial replacement of coarse aggregate in the fibre reinforced concrete curved beam under static and impact load

The investigation is focused on the utility of steel slag in the reinforced concrete beams under static and impact loads through the experiment and simulations. The partial substitution of conventional coarse aggregate with steel slag aggregate 30 % and fibre volume was fixed at 0.75 %, were considered. The three-point bending test is used to evaluate the static response, while a impact test was employed for impact tests. It was observed that the influence of steel slag in the curved beam is found to be increased 36 % as compared to curved beam without steel slag, however, the addition of steel slag aggregate in the straight beam improves marginally, i.e. 4 % under static loading. In case of impact loading, the influence of steel slag in the curved beam is found to be increased 14 % whereas the addition of steel slag aggregate in the straight beam improves, i.e. 7 %, as compared to curved beam without steel slag. It is also concluded that the measured peak acceleration of MSS0 beams found higher as compared to the MSS30 and the reason may be due to the material density influences the acceleration of wave generated by the impact load. Also, the crack width in the straight beam MSS30 is 15 mm whereas same for the MSS0 mix found to be 35 mm and the reason for lesser crack width attributed to the good bonding between the steel slag aggregate and the concrete matrix lead to better ITZ. It was also observed that the crack width in the curved beam found to be 10 and 30 mm for MSS30 and MSS0, respectively. The measured acceleration found to be higher of MSS0 as compared to the MSS30. Further, the finite element analysis was performed using ABAQUS CAE and the concrete damage plasticity model and Johnson-Cook (J-C) material model were used in order to model the behavior of concrete and steel bar, respectively. The maximum deviation on the impact force on straight beam under static analysis (ABAQUS/Standard) found to be 21 % whereas same was found to be 12 % in the impact analysis (ABAQUS/Explicit).

Forming Limits Prediction of Laminated SUS430/Al1050/SUS430 Composites and the Effect of Component Properties on Mechanical Performance

In this study, a constitutive model applied to predict the tensile properties and fracture behavior of well‐bonded multilayered metal composites is extended. The equivalent single‐layer model, as a convenient method, is introduced into finite‐element simulations by combining it with an improved Xue–Wierzbicki damage plasticity model that considers material anisotropy. The steel use stainless (SUS) 430/Al1050/SUS430 laminated sheet fabricated by cold rolling is selected as the research material. The quasistatic uniaxial tests and Nakazima tests are operated to verify the accuracy of the proposed method. The mean errors in tensile stress and fracture forming limit strains are 2% and 3%, respectively. A load‐sharing mixture rule is proposed to assess the effects of the volume fraction, strength coefficient, and hardening exponent of the constituent materials on the mechanical properties of the laminates. In the results, it is indicated that the laminate exhibits sufficient elongation and remains markedly enhanced in tensile strength, reaching 470 Mpa when the ductile Al layer is combined with the higher strength and hardenability steel layer. In this research, it is aimed to clarify the formability characteristics in laminated composites for optimal sheet configuration design and development.

Application of single surface isotropic damage plasticity model in nonlinear dynamic analysis of the Koyna Dam

PurposeIn the present study, the application of a recent damage plasticity model is presented for nonlinear dynamic analysis of the Koyna gravity dam. This is a single surface isotropic damage plasticity concrete model, which is based on the decomposition of stresses and was proposed in a previous study. The theoretical aspects of the model are initially reviewed, and a few preliminary verification examples are illustrated. Thereafter, the HHT-α (i.e. Hilber–Hughes–Taylor) algorithm is presented for nonlinear dynamic analysis of concrete gravity dams.Design/methodology/approachBased on the prepared tools, nonlinear behavior of the Koyna Dam is studied by applying the invoked damage plasticity model. For this purpose, three cases are considered for the present study. Case A, which is based on the linear model, is mainly used for comparative purposes. The other two cases (B and C) correspond to the nonlinear (i.e. damage plasticity) model. The basic data for these two cases are similar. However, the employed damping algorithms are different and correspond to constant and variable damping algorithms, respectively. This means that the damping matrix is either kept constant or updated for all iterations of different time increments through the course of analysis.FindingsThe time histories of horizontal displacement at the dam crest were initially compared for the three cases: the linear Case A, and two nonlinear Cases B and C. It was observed that nonlinear cases’ responses begin to deviate from the corresponding linear case after the time of about 4.3 s. However, the amount of change for Case C (i.e. variable damping) was much greater than for Case B (i.e. constant damping). This was manifested initially in the peaks of response. It was also noticed that the period of response changed slightly for Case B in comparison with the linear Case A, while this change was significant for Case C. The obtained tensile and compressive damages were subsequently compared for the two nonlinear cases. For constant damping Case B, it was noticed that tensile damage occurred in the D/S face kink and on the U/S face slightly at a lower elevation. Moreover, it had a scattered nature. However, in variable damping Case C, it was noticed that tensile damage was much more localized and acted similar to a discrete crack. Of course, both cases also show tensile damages at the dam’s heel. In regard to compressive damages, it is observed that low values are occurring for both nonlinear cases as expected.Originality/valueThe application of a recent single surface isotropic damage plasticity concrete model is presented for nonlinear dynamic analysis of the Koyna gravity dam. The nonlinear response of the dam is investigated for two different damping algorithms. Moreover, the influence of variable characteristic length is also investigated in the latter part of this study.

Thickness-dependent micro-fracture behaviors of pre-cracked aluminum plates by crystal plasticity finite element method and damage criteria

Despite the fact that fracture behaviors of pre-cracked metal plates were investigated by the crystal plasticity finite element method (CPFEM), the thickness effect on their micro-fracture behaviors is still not clear because of the different out-of-plane constraints. Here, mechanical properties and micro-fracture patterns of pre-cracked aluminum plates with different thicknesses are obtained by experiments, as well as by CPFEM combining with two damage criteria. First, finite element models are constructed based on grain morphologies of specimens achieved by electron back scattered diffraction experiments. Next, some key parameters required in CPFEM and two damage criteria are determined by fitting experimental stress–strain relationships. In particular, the factors affecting accuracy of FE predictions are clarified by CPFEM. Finally, thickness-dependent micro-fracture mechanisms of two different damage criteria in pre-cracked aluminum plates with various thicknesses and crack lengths are revealed by comparison with the experimental results and CPFEM. This investigation should be of great help for understanding thickness-dependent micro-fracture mechanisms of metal and other material plates.

Extension of Flow Behaviour and Damage Models for Cast Iron Alloys with Strain Rate Effect

Cast iron alloys with low production cost and quite good mechanical properties are widely used in the automotive industry. To study the mechanical behavior of a typical ductile cast iron (GJS-450) with nodular graphite, uni-axial quasi-static and dynamic tensile tests at strain rates of 10−4, 1, 10, 100, and 250 s−1 were carried out. In order to investigate the influence of stress state on the deformation and fracture parameters, specimens with various geometries were used in the experiments. Stress strain curves and fracture strains of the GJS-450 alloy in the strain rate range of 10−4 to 250 s−1 were obtained. A strain rate-dependent plastic flow model was proposed to describe the mechanical behavior in the corresponding strain-rate range. The available damage model was extended to take the strain rate into account and calibrated based on the analysis of local fracture strains. Simulations with the proposed plastic flow model and the damage model were conducted to observe the deformation and fracture process. The results show that the strain rate has obviously nonlinear effects on the yield stress and fracture strain of GJS-450 alloys. The predictions with the proposed plastic flow and damage models at various strain rates agree well with the experimental results, which illustrates that the rate-dependent plastic flow and damage models can be used to describe the mechanical behavior of cast iron alloys at elevated strain rates. The proposed plastic flow and damage models can be used to describe the deformation and fracture analysis of materials with similar properties.

Dynamic Response of Ti-6Al-2Zr-1Mo-1V Alloy Manufactured by Laser Powder-Bed Fusion.

Titanium parts fabricated by additive manufacturing, i.e., laser or electron beam-powder bed fusion (L- or EB-PBF), usually exhibit columnar grain structures along the build direction, resulting in both microstructural and mechanical anisotropy. Post-heat treatments are usually used to reduce or eliminate such anisotropy. In this work, Ti-6Al-2Zr-1Mo-1V (TA15) alloy samples were fabricated by L-PBF to investigate the effect of post-heat treatment and load direction on the dynamic response of the samples. Post-heat treatments included single-step annealing at 800 °C (HT) and a hot isotropic press (HIP). The as-built and heat-treated samples were dynamically compressed using a split Hopkinson pressure bar at a strain rate of 3000 s-1 along the horizontal and vertical directions paralleled to the load direction. The microstructural observation revealed that the as-built TA15 sample exhibited columnar grains with fine martensite inside. The HT sample exhibited a fine lamellar structure, whereas the HIP sample exhibited a coarse lamellar structure. The dynamic compression results showed that post-heat treatment at 800 °C led to reduced flow stress but enhanced uniform plastic strain and damage absorption work. However, the HIP samples exhibited both higher stress, uniform plastic strain, and damage absorption work owing to the microstructure coarsening. Additionally, the load direction had a subtle influence on the flow stress, indicating the negligible anisotropy of flow stress in the samples. However, there was more significant anisotropy of the uniform plastic strain and damage absorption. The samples had a higher load-bearing capacity when dynamically compressed perpendicular to the build direction.

An algorithm based on B-differentiable equations method for solving problems involving frictional contact coupled with concrete plastic damage

In this paper, an algorithm is proposed to solve the frictional contact problems while considering elasto-plastic material properties. The static and dynamic solution procedures are derived in incremental form, respectively. The proposed method employs a two-layer iteration strategy. In the outer iteration layer, the equilibrium equations are solved, with the stress and stiffness matrix updated at each iteration. Within the inner iteration layer, the contact force is calculated, where the contact equations, expressed as B-differentiable equations, incorporate only contact conditions in normal and tangential directions, and the contact flexibility matrix, obtained by applying unit force pair to all contact node pairs in turn, is introduced. Consequently, the solution for nonlinear equilibrium equations and contact equations is decoupled, requiring only one decomposition of the stiffness matrix for each calculation of the contact flexibility matrix, as it remains constant within the contact iteration layer. In addition, the constitutive model of concrete developed by Lee and Fenves is utilized. This model adopts two independent variables to describe tensile and compressive damage, together considering the strength recovery of the concrete. Numerical examples demonstrate the accuracy of the proposed method by comparing the results from Abaqus. Furthermore, the present algorithm is applied to static and dynamic analyses of a concrete arch dam with several transverse joints, where the effects of gravity, water level, the number of contact surfaces, and seismic load are considered, and some conclusions are obtained.

DEVELOPING SPECIALIZED SOFTWARE FOR PROGRESSIVE COLLAPSE ANALYSIS OF PLANE FRAME STRUCTURES USING THE PLASTIC DAMAGE INDEX

In this study, the authors developed software named Sonar to analyze the progressive collapse of structural elements. This software is capable of assessing the level of damage to each structural component and automatically updating the structural model for subsequent analyses. The software features a user-friendly interface, intuitive graphics, easy input of parameters, and presents computational results in 2D graphics. Through the use of the developed software, damaged structures were analyzed and studied to conclude that considering the progressive collapse of elements based on the plastic damage index serves as a basis for investigating specific design problems to propose more optimal design solutions.

Numerical study of low‐rise composite steel frame responses to blast loading using direct simulation method

AbstractThis paper investigated the blast behavior of a low‐rise composite steel structure of three stories subjected to internal and external explosions for the same explosive charge of 250 kg TNT. A comparison of three various blast scenarios is aimed at better understanding how blast waves propagate in confined risk zones and their damage effects on far and exposed elements to an explosive charge. Evaluation of the damage level and the overall response of the proposed numerical model is done by estimating the adequacy of structural members subjected to blast loading using general limits in attempting to check the structure's strength and regularity. The analysis was based on load combinations and damage criteria according to the Unified Facilities Criteria which are general design approaches suitable for civil design applications in forecasting blast loads and structural system responses. The overall behavior of this structure was simulated based on a dynamic analysis by the direct simulation approach, which was chosen for modeling blast loads using the Friedlander blast load equation, and the simpler, less expensive, more accurate, and realistic A.T.‐BLAST model to deduce the simplified blast‐wave overpressure profile. The material nonlinearity at a high strain rate using the Johnson‐Cook strength and concrete plasticity damage model is studied dynamically using ABAQUS finite element code to simulate the explicit dynamic nonlinear analysis. The overall response of the proposed numerical model was evaluated by estimating the adequacy of structural members, considering the blast load as the initial cause of failure, such as axial plastic strain, internal forces limits, maximum deformation, support rotation, demand‐capacity‐ratio (DCRshear/moment), drift index and material damage model. The position of the explosive charge played an important role in determining the rate at which the structural element begins to plastic strains, displacements, moments, or rotations beyond the limits, and then key elements should be considered in structural design against progressive collapse. Results showed that steel members exhibit early indicators of failure, such as buckling necking, shear tearing, or plastic hinges, whereas concrete slabs break up immediately due to brittleness. DCRmoment values successfully showed the columns in which the first plastic joint can occur, whereas DCRshear values signaled the onset of shear failure at connections. Besides, plastic hinges played an important role in dissipating energy and preventing total structural collapse via the Strong Column‐Weak Beam design concept, which appears repeatedly in this study. The structure is a well‐designed and ductile building capable of supporting higher loads and is considered to be repairable and intact.

A 3D thermo-mechanical damage model for concrete including Short-Term Thermal Creep Strain (STTCS)

In the current study, a Short-Term Thermal Creep Strain (STTCS) model of concrete was innovatively developed. This model can predict the time-dependent deformation of concrete subjected to wide applied load level ranging from 20 % to 60 % and temperatures up to 900 °C. A creep compliance function was developed to study the nonlinear creep characteristics of concrete with creep parameters. The definition and sensitivity of the creep parameters were investigated. In order to comprehensively predict the performance of concrete subjected to multiaxial compressive loads in fire, an orthotropic triaxial compression thermo-mechanical damage model for concrete is developed. The influence of STTCS on the multiaxial stress-strain behaviors was taken into account in the multiaxial model. The coupling thermo-mechanical contributions containing the development of STTCS with thermal effect, stress confinement, plastic damage and hardening evolution were creatively considered in the potential function within thermodynamics framework. The sensitivity of yield surface was discussed. The numerical operations of this proposed model were conducted for validation. The nonlinear stress-strain responses of concrete were accurately captured at temperatures ranging from 20 °C to 800 °C through the comparative study with test results in literatures, which indicates the accuracy and applicability of the proposed model.

Numerical Modeling of Four-Pile Caps Using the Concrete Damaged Plasticity Model

Four-pile caps made from concrete are essential elements for the force transfer from the superstructure to piles or pipes. Due to the difficulties in carrying out full-scale tests and all the instrumentation involved, the use of numerical models as a way to study the mechanical behavior of these elements presents itself as a good alternative. Such numerical studies usually provide useful information for the update and improvement of normative standards and codes. The concrete damaged plasticity (CDP) constitutive model, which combines damage and plasticity with smeared-crack propagation, stands out in the simulation of reinforced concrete. This model is composed of five parameters: dilatation angle (ψ), eccentricity (ϵ), ratio between biaxial and uniaxial compressive strength (σbo/σco), failure surface in the deviator plane normal to the hydrostatic axis (Kc), and viscosity (μ). For unidimensional elements, the values of the CDP parameters are well defined, but for volumetric elements, such as concrete pile caps, there is a gap in the literature regarding the definition of these values. This fact ends up limiting the use of the CDP on these structural elements due to the uncertainties involved. Therefore, the aim of this research was to calibrate two numerical models of concrete four-pile caps with different failure modes for the evaluation of the sensitivity of the CDP parameters, except for ϵ, which remained constant. As a result, the parameters σbo/σco and Kc did not significantly influence the calibration of the force × displacement curves of the simulated structures. Values of ψ and μ equal to 36° and 1 × 10−4, respectively, are recommended for “static” analysis, while for “quasi-static” analysis, ψ values ranging between 45° and 50° are suggested according to the failure mode. The results also showed to be sensitive to the constitutive relation of concrete tensile behavior in both modes of analysis. For geometric parameterization, the “static” analysis is recommended due to the lower coefficient of variation (3.29%) compared to the “quasi-static” analysis (19.18%). This conclusion is supported by the evaluation of the ultimate load of the numerical models from the geometrically parametric study compared to the results estimated by an analytical model.

Study on the mechanical properties of recycled brick coarse aggregate concrete based on finite element modeling

In recent years, the use of recycled materials in concrete production has garnered significant attention due to their environmental and economic benefits. To promote the application of recycled aggregates, this study focuses on investigating the utilization of Recycled Brick Coarse Aggregate (RBCA) as a substitute for natural aggregate. This paper presents the development of stochastic convex polygonal RBCA through the utilization of a custom-programmed algorithm and proposes a finite element model designed to simulate the behavior of RBCA concrete under compression and splitting tensile. Numerical simulations were conducted to investigate the effects of brick aggregate Replacement Rate (RR) and porosity on the compressive and splitting tensile properties of RBCA concrete. A strong correlation was found between the Concrete Damage Plasticity (CDP) model developed in this study and experimental results, indicating high reliability. The results indicate that the replacement rate of brick aggregates has a more significant impact on the compressive strength than on the splitting tensile strength of concrete. Furthermore, the distribution of coarse aggregates and pores has a minor influence on the mechanical properties and ultimate failure mode of RBCA concrete but significantly affects the crack distribution pattern. The sequence of damage initiation in RBCA concrete was found to be: pores, old Interfacial Transition Zone (ITZ), old mortar, new ITZ, new mortar, RBCA, and Natural Coarse Aggregate (NCA). These findings contribute to a comprehensive understanding of RBCA's performance and offer valuable insights for optimizing its behavior.

Modelling of energy harvesting with bendable concrete and surface-mounted PVDF

Polyvinyl alcohol fiber reinforced engineered cementitious composite (ECC) using piezoelectric polymer film has attracted significant interest due to its energy harvesting potential. This work provides a theoretical model for evaluating the energy harvesting of bendable ECC using surface-mounted polyvinylidene fluoride (PVDF). In the mechanical part, concrete damage plasticity model based on the explicit dynamic analysis was utilized to simulate the dynamic flexural behavior of ECC beam under different dynamic loading rates. The mechanism of force transfer through the bond layer between the PVDF film and ECC specimen was simulated by a surface-surface sliding friction model wherein the PVDF film was simplified as shell element to reduce computational cost. Then, the electromechanical behavior of the piezoelectric film was simulated by a piezoelectric finite element model. A simplified model was also given for a quick calculation. The theoretical model was verified with the experimentally measured mechanical and electrical results from the literature. Finally, a parametric analysis of the effects of electromechanical parameters on the efficiency of energy harvesting was performed. The verified theoretical model can provide a useful tool for design and optimization of cementitious composite systems for energy harvesting application.

Lining Structure of Water Conveyance Tunnel under Earthquake Action Research on Damage Law

Based on the concrete damage plasticity constitutive model (CDP model) of ABAQUS software, the dynamic response of high pressure internal water conveyance tunnel during earthquake is simulated, and the dynamic response and dynamic damage law of high internal water pressure water conveyance tunnel structure under surrounding rock grade, buried depth and seismic wave intensity are analyzed. The research shows that the surrounding rock grade is closely related to the dynamic response and damage characteristics of the lining structure of the water conveyance tunnel. The dynamic damage of the tunnel under grade Ⅲ surrounding rock is only 0.08, which is far less than 0.83 under grade Ⅳ surrounding rock. It can be considered that it will not cause great damage to grade Ⅲ surrounding rock under earthquake. The surrounding rock grade is better, which can provide more stable support and reduce the stress and vibration of the structure. If the tunnel is in the seismic zone, the buried depth can be used as one of the design control indexes in the tunnel design. The lining damage is mainly distributed at the top and upper arch waist of the tunnel. With the increase of the buried depth of the tunnel, the dynamic damage amount increases from 0.021 to 0.081, then to 0.085. the damage of the lining structure also increases. This may be because the deep buried tunnel is more constrained by the underground rock and soil layer, thereby reducing the transmission of seismic load. The change of seismic wave intensity can directly affect the damage characteristics of tunnel lining structure. The dynamic damage mainly occurs at the vault and arch waist, and the damage area expands from the vault and arch waist to the side wall and corner. The increase of seismic wave intensity will lead to dramatic changes in the stress of the structure, which will lead to more complex and serious damage.

Damage characteristics and mechanical properties of CRTS III track structure in curved sections under longitudinal uneven subgrade settlement

This paper first presents a CRTS III track structure (TS) model specifically designed for curved sections, highlighting its adjustable superelevations feature that enhances adaptability to various high-speed railway curve profiles. The model considers the distribution of steel bars within the TS, concrete damaged plasticity, as well as contact nonlinearity. Afterward, the intricate impacts of longitudinal uneven subgrade settlement (LUSS) position (7 positions), amplitude (5–30 mm), wavelength (5–30 m), and TS superelevation (15–175 mm) on structural damage, stress, deformation, and interlayer gap are studied. The findings reveal that: 1) Under different LUSS positions, the concrete base (CB) experiences the most severe damage, particularly on its thick side. For the TS with 175 mm superelevation, in the wavelength range of 10–20 m, the maximum damage value of CB exceeds 0.9 when LUSS amplitude reaches 20 mm. With the movement of LUSS position, the main damage position of CB changes obviously. When the concrete stress reaches the tensile strength, the steel bars located in adjacent positions progressively assume the primary role in load-bearing. 2) The influence of LUSS on TS deformation and interlayer gap is inevitably associated with the distance between settlement center and expansion joints. Interlayer gaps vary among structural components, which are primarily distributed near settlement center, expansion joints, and settlement edges. 3) As the amplitude increases, both CB and self-compacting concrete layer (SCCL) damage are aggravated. Increasing wavelength initially causes damage to increase, then decrease, and 10–20 m is the most unfavorable wavelength range for most cases. 4) The effect of superelevation on TS damage is complex, varying with structural components and settlement characteristics. In most cases, as superelevation increases, the damage to CB increases, whereas the deformation decreases.

Fatigue Life Prediction for 2060 Aluminium–Lithium Alloy with Impact Damage

The paper investigates the issue of post-impact fatigue damage of the 2060 aluminium–lithium alloy, a representative material of third-generation aluminium–lithium alloys extensively employed in the fuselage of C919 aircraft due to its notable attributes of high specific stiffness and strength. Initial impact damage is identified utilizing a residual stress–strain field obtained from a quasi-static simulation. Then, the continuum damage mechanics approach is applied to predict the fatigue life of the impacted 2060 aluminium–lithium alloy plates accounting for the combined effects of residual stress, plastic damage, and fatigue loading. A comparative analysis between calculated and experimental results is conducted to validate the efficacy of the proposed methodology.

Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional synaptic plasticity

Alzheimer’s disease (AD) is characterized by cognitive impairment, loss of learning and memory, and abnormal behaviors. Scopolamine (SCOP) is a non-selective antagonist of muscarinic acetylcholine receptors that exhibits the behavioral and molecular hallmarks of AD. Vanillic acid (VA), a phenolic compound, is obtained from the roots of a traditional plant called Angelica sinensis, and has several pharmacologic effects, including antimicrobial, anti-inflammatory, anti-angiogenic, anti-metastatic, and antioxidant properties. Nevertheless, VA’s neuroprotective potential associated with the memory has not been thoroughly investigated. Therefore, this study investigated whether VA treatment has an ameliorative effect on the learning and memory impairment induced by SCOP in rats. Behavioral experiments were utilized to assess the learning and memory performance associated with the hippocampus. Using western blotting analysis and assay kits, the neuronal damage, oxidative stress, and acetylcholinesterase activity responses of hippocampus were evaluated. Additionally, the measurement of long-term potentiation was used to determine the function of synaptic plasticity in organotypic hippocampal slice cultures. In addition, the synaptic vesicles’ density and the length and width of the postsynaptic density were evaluated using electron microscopy. Consequently, the behavioral, biochemical, electrophysiological, and ultrastructural analyses revealed that VA treatment prevents learning and memory impairments caused by SCOP in rats. The study’s findings suggest that VA has a neuroprotective effect on SCOP-induced learning and memory impairment linked to the hippocampal cholinergic system, oxidative damage, and synaptic plasticity. Therefore, VA may be a prospective therapeutic agent for treating AD.

Influence of Foundation Stiffness on the Fragility Curves of a Concrete Gravity Dam Subjected to Near-Field Ground Motions Using Finite Element Method

A concrete gravity dam is being investigated to determine the fragility curves during near-field ground motions under various foundation stiffness conditions. This is accomplished using the finite element method for modeling the Latyan dam and its dam-reservoir-bed complex interaction system. The nonlinear constitutive model of concrete, plastic damage, is used to simulate the cyclic behavior of tensile and compressive failures in concrete. An acoustic element is used to model the propagation of compressive waves in the reservoir to account for the hydrodynamic effects of the lake reservoir. A total of 100 real and scaled accelerograms are used to simulate near-filed seismic loading in eight different concrete-to-foundation stiffness ratios. Based on the peak ground acceleration (PGA) of the earthquake, numerical models are applied to obtain the probability density function (PDF) and cumulative distribution function (CDF) for lognormal distributions and to determine and analyze the fragility curves of the dam. According to the findings, the seismic performance of the dam is improved for stiffness ratios of 0.75, 1, and 1.5, and the best seismic performance is determined for stiffness ratios of 1. Concrete dams with stiffness ratios of 0.75, however, perform better when the peak ground acceleration is greater than 0.74g compared to those with stiffness ratios of 1. DOI: https://doi.org/10.52783/pst.502