In recent years, titanium has become a material of major interest in prosthetic dentistry. Due to its chemical properties, titanium has to be processed differently from conventional alloys. In this paper, two different methods of welding were investigated. Specimens machined from pure titanium rods were fused either by laser welding or plasma welding. Hardness profiles and light microscopy images were taken in the region of the weld. The mechanical properties were tested by alternating bending fatigue tests up to 3 million cycles. Light microscopy images and hardness profiles showed a larger heat-affected zone after plasma welding compared to laser welding. No significant differences comparing fatigue strength could be found between the two methods of welding. However, extreme loads led to earlier fatigue in the plasma-welded specimens. SEM images of the laser-welded joints showed fractures in the welding zone, while the plasma-welded specimens fractured mostly beyond the heat-affected zone. From these results, it can be assumed that both methods are suitable for welding titanium. At the moment, laser welding is the more suitable technique in dentistry because of its lower thermal alteration of the workpieces.