Postheparin Plasma Lipolytic Activity Research Articles

LIPOLYTIC ACTIVITY OF POST-HEPARIN PLASMA IN HYPERLIPEMIA AND HYPOLIPEMIA.

(1) The role of post-heparin plasma lipolytic activity (PPLA) in the production of hyperglyceridemia was investigated in patients with high concentrations of plasma triglycerides produced in two ways, viz. fat-induced and "mixed" (both fat and carbohydrate-induced). While on a self-chosen diet, the PPLA levels of patients with "mixed" type of hyperglyceridemia differed little from those of young healthy subjects. PPLA levels of these patients were promptly lowered by rice diet, despite the persistence of hyperglyceridemia. Normal serum lipid concentrations and low PPLA levels were induced and maintained in these patients by reducing moderately their intake of both dietary fat and calories. (2) PPLA levels were reduced in the fat-induced hyperglyceridemic patients both before and after the use of low fat diet to reduce their plasma triglyceride concentrations. (3) PPLA was also low in patients with low and absent beta-lipoproteins, and in those with disturbance of intestinal fat digestion and absorption.

POSTHEPARIN PLASMA LIPOLYTIC ACTIVITY (PHLA) IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS.

POSTHEPARIN PLASMA LIPOLYTIC ACTIVITY (PHLA) IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS.

Studies indicating inactivation of post-heparin and endogenous human plasma lipoprotein lipase during triglyceride lipolysis.

Evidence has been obtained by in vitro studies that human post-heparin and endogenous plasma lipolytic activity (lipoprotein lipase) are inactivated during the process of triglyceride lipolysis. Addition of heparin to supernatant plasma after removal of lipoprotein lipase activity by Ca3(PO4)2 adsorption occasionally restores its lipemia clearing activity. This indicates that heparin is a component of the enzyme, and that its dissociation from the apoenzyme readily occurs.