ObjectiveOvernight fasting blood plasma insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-1 (IGFBP-1), coenzyme Q10, (CoQ) vitamin E and plasma lipids were compared between a semi-nomadic Samburu population and relatively urbanized cohorts from Nairobi, Kenya. Research design and methods143 middle aged subjects without known diabetes were included. IGF-I and IGFBP-1 were analyzed by RIA, and CoQ and vitamin E by HPLC. Plasma lipid levels were analyzed by standard laboratory methods routinely used in the clinics. ResultsThe age adjusted IGF-I serum levels were low in the Samburu male and female populations, ranging from 0 to −4 IGFSD-score (SDS), and a minor part of the investigated population reaching as low as −5 and −7 SDS. The Nairobi cohorts showed significantly higher values reaching from −2.5 to +1 SDS (P<0.0001). The nomadic Samburu population showed fasting IGFBP-1 values ranging from 30–100μg/l, while that of the urbanized Nairobi cohorts was considerably lower (25–60μg/l) (P<0.0001). CoQ concentrations of the Nairobi cohorts were 1.5–2.0nmol/ml similar to the levels found in several European countries. The Samburu population on the other hand showed extremely high CoQ values ranging from 2 to 9nmol/ml (P<0.0001). Vitamin E levels of the Nairobi group were low (5–20nmol/ml), but the Samburu population had even lower levels ranging from 3 to 15nmol/ml (P<0.0001). Plasma lipid levels such as cholesterol, triglycerides, LDL/HDL, ApoB/ApoA ratios as well as BMI and weight were significantly higher in the Nairobi population (P<0.0001). ConclusionsLow IGF-I and high IGFBP-1 levels of the Samburu cohorts indicate malnutrition. High lipid levels of the Nairobi cohorts indicate that these groups have several risk factors for cardiovascular diseases and diabetes type2.