Laser-matter interactions with metal target cause plasma explosion and shock accelerated variable density flow instabilities in the Semiconfined Configuration (SCC). Their study gives deeper insight into the flow instabilities present in all microchannel devices. Blast wave motion along the SCC microchanel causes the Kelvin–Helmholtz (KH) instability and formation of vortex filaments for the critical Reynolds number. Appearing in all shear layers—it affects the fluid transport efficiency. Shear layer acceleration causes a Raleigh-Taylor instability (RTI). Oriented bubble growth by discrete merging indicates anisotropic RTI mixing. Similar RTI flame instability appears in the conversion of chemical energy into electricity affecting microcombustion efficiency. Another case of anisotropic RTI is the flow boiling for cooling of chips and microelectronic devices. The RTI boiling which appears for the critical heat flux is based on rising surface vapor columns (oriented bubble growth) with liquid counterflow (spike prominences) for the critical wavelength at density interface. The RT bubble merging graph trees determine turbulent mixing which affects the heat transfer rates. Bottom-wall turbulent flow in the SCC microchannel causes streaks of the low momentum fluid and formation of hairpin vortex packets with lattice organization. This makes possible to quantify parameters responsible for the evolution of hairpin vortex packets in the microchannel devices. Appearing from the low to the high Reynolds numbers they affect the transport properties, control of the fluid motion, enhancement of mixing, or the separation of fluids. Fluid particle ejecta—thin supersonic jets - evolve into long needle-like jets which start spiraling, helical pairing and swirling in the field of thermal gradients. Such instabilities appear in the microcombustion flame instability and in the space micropropulsion systems. Oscillating and spiral flames appear in the presence of thermal gradient in the microchannel, due to the combined effects of thermal gradient fields and the mixture flow rates.