Plasma Exeresis Research Articles

Plasma Exeresis for the Treatment of Benign Eyelid Lesions: A New Surgical Approach.

To report the plasma therapy technique and its clinical outcomes in patients with benign eyelid lesions. This is a retrospective, noncomparative, interventional study. The study included 71 eyes of 66 patients who underwent plasma exeresis for benign eyelid lesions in our clinic between February 2018 and December 2022. Patient symptoms, cosmetic outcomes, and complications were evaluated. The lesions were removed with a single plasma exeresis treatment in all patients. The mean size of the lesion at its largest part was 5.5 ± 1.2 mm (range, 3.0-8.8 mm). No complications were encountered during the procedure. The mean procedure time was 4.0 ± 0.7 minutes (range, 3-6 minutes). Postoperatively, only 3 cases (4.2%) with tarsal conjunctival extension had mild irritation symptoms such as pain, discomfort, and redness. The treated areas were fully improved cosmetically, and all patients were satisfied with the cosmetic outcomes. The plasma therapy technique for removing benign eyelid lesions offers minimally invasive surgery, less discomfort, fast recovery, and successful anatomical and cosmetic outcomes.

Comparing the efficacy of plasma exeresis and cryotherapy for the treatment of seborrheic keratosis: A randomized controlled trial.

Seborrheic keratoses (SK) is a benign epithelial skin tumor and plasma exeresis is a new technique. To compare the efficacy and safety of plasma exeresis and cryotherapy for treating SK. This study is a randomized controlled trial (RCT). One side of each patient was randomly treated with plasma exeresis (peak-to-peak voltage of 3.44kV and a frequency of 62.5kHz) and the other side with cryotherapy. Thirty-five males were enrolled. At week 3, 37.1 % (N=13) of lesions treated by plasma exeresis were clear, which was higher than those treated by cryotherapy 17.1% (N=6). However, this difference was not significant (p-value: 0.06). At week 6, 16 (57.1 %) out of 28 remaining lesions, treated by plasma exeresis were clear, which was significantly higher (p-value: 0.005) than those completely cleared by cryotherapy in 6 out of 29 remaining lesions (20.7%). The mean physician assessment scale score was significantly reduced in both groups in the second follow-up (plasma group first follow-up 0.91±0.89vs. second follow-up 0.5±0.64 and p-value: 0.0031; cryo group first follow-up 1.4±0.84vs. second follow-up 1.1±0.72 and p-value: 0.0002). Regarding side effects, no significant difference was seen (p=0.438). The most common complications in the plasma and cryotherapy groups were erythema (10/19, 52.63%) and hypo pigmentation (5/13, 38.46%). Both cryotherapy and plasma exeresis are effective. We observed a significantly higher cleared lesions treated with plasma exeresis in 6weeks and after two sessions.

Modern blepharoplasty: From bench to bedside.

The demand for procedures aiming to rejuvenate the upper third part of the face and the periocular region has increased in the past several years. Blepharoplasty is one of the most frequently performed procedures worldwide to date. Surgery is currently the first choice in order to achieve permanent and effective results; however, it is burdened by potential surgical complications feared by patients. There is an increasing trend in individuals to request less invasive, non-surgical, effective, and safe procedures for eyelid treatment. The aim of this minireview is to present a brief overview of non-surgical blepharoplasty techniques that have been reported in the literature in the past 10 years. Numerous modern techniques that provide a rejuvenation of the entire area have been described. Numerous less invasive methods have been proposed in the current literature and in modern-day routine clinical settings. Dermal fillers are a commonly chosen option for providing enhanced aesthetic results, especially considering that volume loss can be one of the main underlying causes of facial and periorbital aging. Deoxycholic acid use may be considered when the problem is represented by periorbital excess fat deposits. The simultaneous excess and loss of elasticity of the skin can be assessed with techniques such as lasers and plasma exeresis. Furthermore, techniques such as platelet-rich plasma injections and the insertion of twisted polydioxanone threads are emerging as viable methods to rejuvenate the periorbital region.

Keloid Treatment Using Plasma Exeresis: A Pilot Trial Study

Introduction: Keloid scars and hypertrophic scars are more commonly seen after surgeries, suture placements, or other skin damages. Scars can be treated using a variety of methods, including topical compounds, surgery, and lasers. The aim of this study is to evaluate the effects of plasma exeresis on the treatment of keloid scars. Methods: This experimental study was conducted on patients with keloid scars, defined as a treatment-resistant subtype of scars with extension beyond the primary skin defect and cauliflower appearance, in different parts of the body. The patients were treated with 2-to-3-session plasma exeresis. Scars were examined based on the Vancouver scar scale (VSS) before and 5 months after the treatment. Results: A total number of 24 scars were enrolled in this study. The number of patients was 16. There was a decrease in the mean thickness of keloids from 2.20 to 0.54 (P=0.000). The mean pigmentation and pliability scores decreased from 1.54 and 2.16 to 0.375 and 0.541, respectively (P=0.001, 000). There was a significant reduction in the keloid scar vascularity score from 1.666 to 0.541 (P=0.000). There was a decrease from 0.708 to 0.00 (P=0.004) in the mean itchiness score. After the intervention, the mean pain score was 0.000, compared to 0.7500 before the intervention (P=0.003). There was a decrease in the total score from 8.958 to 2.000 (P=0.000). Conclusion: The plasma exeresis procedure is effective in destroying small keloid scars. Furthermore, results in less itching and pain, as well as no significant complications or recurrences.

Plasma Exeresis Technology for Rejuvenation of the Upper Eyelid

Plasma Exeresis Technology for Rejuvenation of the Upper Eyelid

Upper eyelid blepharoplasty using plasma exeresis: Evaluation of outcomes, satisfaction, and symptoms after procedure.

Facial care treatments have grown a remarkable demand for effective and minimally invasive techniques with fast recovery time. Plasma technology is a nonsurgical alternative technique for skin rejuvenation. We assessed patient satisfaction and symptoms after upper eyelid blepharoplasty with plasma technology. Observational study including 16 patients submitted to upper eyelid blepharoplasty using plasma technology to treat dermatochalasis. Patient satisfaction, symptoms, and quality of life were assessed using 2 questionnaires at follow-up days 7 and 30. Also, the answers were correlated with age, Fitzpatrick skin type, and quantity of eyelid skin treated with plasma. All 16 patients were treated and completed the survey. Fourteen (87.5%) were female, and the mean age was 50.5years. Physical appearance was the most relevant factor impacting on quality of life at first week postoperative. Regarding satisfaction with results, most patients stated higher level of satisfaction at day 7 follow-up analysis (P=.038). Less impact on quality of life and higher satisfaction was associated with eyelid-treated area (P=.044 and P=.036) and Fitzpatrick skin type (P=.043) at 7 and 30days after procedure, respectively. Eyelid edema and itching were the symptoms most reported at 7 and 30days, respectively. Upper blepharoplasty with plasma is a minimally invasive treatment with low impact on quality of life. However, overall patient satisfaction is questionable when considering less willing of undergoing procedure again and decreased expectation with results over postoperative period. Symptoms are reported mainly at the first week after procedure.

Eradication of Benign Skin Lesions of the Face by Voltaic Arc Dermabrasion (Atmospheric Plasma): Postoperative Pain Assessment by Thermal Infrared Imaging

ObjectivesThe face aging processes are associated with physiologic and biochemical alteration that produces wrinkles, skin pigmentation and benign growths. The aim of this study was to evaluate the clinical efficacy of voltaic arc dermabrasion with plasma to remove benign facial skin lesions.Study DesignVoltaic arc dermabrasion plasma technique was used to remove the facial benign skin lesions. The study involved 45 patients (26 females;19 males) treated for benign facial skin lesions with voltaic arc dermabrasion also called plasma exeresis technique. The subjects age ranged between 43 and 65 years. The clinical observations and comparison of pretreatment and post-treatment photographs of the treated regions were performed by a joint examiner at each follow-up visit.ResultsDuring plasma irradiation, the average temperature of the skin was 290.3 ± 21.7 °C, while immediately after it was 90.6 ± 21.8 °C. Overall clinical improvement was 100% in six lesions with complete resolution of all lesions. Three patients observed a transient post-inflammatory pigmentation with a peak at 1 month after VAD treatment, gradually fading spontaneously over 2 to 3 months.ConclusionsThe voltaic arc dermabrasion technique (atmospheric plasma) should be considered for lesions, especially relatively superficial ones, and small lesions that are located on the face.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Evaluation of plasma exeresis as a new technique for non surgical treatment of dermatochalasis

Background Dermatochalasis is frequently associated with tissue ageing and leads to multiple functional and cosmetic issues. There are several possible medical and surgical treatments available, such as blepharoplasty and laser therapy. Objective The aim of this work was to evaluate plasma exeresis as a new technique for nonsurgical treatment of dermatochalasis of the upper eyelid. Patient and methods This clinical trial included 40 female patients with dermatochalasis. Each patient received 3 sessions of treatment with the technology of plasma exeresis with one-month interval. Final evaluation was performed three months after the last session by 2 blinded dermatologists and 2 ophthalmologists, lid laxity according to facial laxity rating scale (FLRS), marginal crease distance (MCD) before and after treatment and patient satisfaction score. Results There was a significant decrease in eye lid laxity (FLRS) after treatment where p < .001; 36 (90%) patients had change and 4 (10%) patients without change in general. There was a significant increase in MCD after treatment (p = .001). Conclusion Plasma exeresis seems to improve appearance of the upper eyelid, without any serious adverse events and could be a valid solution for dermatochalasis especially in mild and moderate cases.

CASE REPORT: The impact of Plasma Exeresis after fillers complication on the lips

The purpose of this article is to inform the medical audience about the treatment of difficult cases by implementing the Plasma Exeresis method. With the particular device of Plasma Exeresis the fourth state of matters, Plasma, is produced. In brief, Plasma Exeresis is a certified cordless micro-surgical hand-operated device. According to the histology results, Plasma Exeresis sublimates the epidermis without passing the membrane basal, shrinking the elastic fibers of the dermis, and produces collagen type III without the unwanted skin lesion. In particular, by using Plasma Exeresis with the above mechanism we are able to rectify the fibrosis and granules (and other medical lesions e.g. xanthelasmas, hemangioma, non-invasive blepharoplasty, papilloma, fibroma, benign tumors, etc.). Furthermore, it accelerates the damage repair, the wrinkles softening and the skin fibers regeneration. The case study discussed below can be characterized for its hard and challenging nature, bearing in mind that the damage was extensive. The patient was a woman, 55 years old, who had undergone an unsuccessful treatment in the past. The case takes place in Greece. The culprit was the application of lip fillers consisted of an unknown material. The adverse effects (granules) (See pictures below) were combined with depressive disorder which lasted for approximately 15 years. The granules were considered by many doctors (even plastic surgeons) insurmountable, however, the Plasma Exeresis method was eventually highly effective. Consequently, the Plasma Exeresis can be considered as an innovative method which can heal and restore problematic cases. Keywords: Plasma Exeresis: Fillers; Complication; Lips; Side Effects; Granules Hypothesis 1: Plasma Exeresis can cure difficult cases

Plasma sublimation for the treatment of xanthelasma palpebrarum

Xanthelasma palpebrarum (XP) is a common xanthomatous lesion of the eyelid and periorbital skin. Several methods of treatment have been reported in the literature, each having its own indications and risks. We present a new treatment method for removing XP using a plasma exeresis device (Plexr®, GMV, Italy). Fifteen patients with a total of 27 treated XPs were assessed and clinically identified by the treating dermatologist. Patients were photographed and assessed by a dermatologist prior to and immediately after treatment. A patient survey was conducted 12 months after the procedure, which assessed the outcome of the procedure (redness, pigmentation disorders, and scars). After just a single treatment session using a plasma sublimation, all 27 XPs showed complete clearance. There were no reports of scars, pigmentary alteration, or recurrence of lesions up to 12 months. We present plasma sublimation as a new method for the treatment of XP. During the procedure, the method allows to control the depth of tissue destruction and the presence of xanthoma tissue, and to minimize pain and trauma, making it particularly ideal for treating areas around the eye.

Plasma Exeresis Treatment for Epidermoid Cysts: A Minimal Scarring Technique.

Epidermoid cysts are cutaneous benign tumors commonly seen in young or middle-aged adults. Plasma exeresis is an innovative technique for several skin conditions: it causes ionization of the atmospheric gas between the proximal tip of the device and the tissue to be treated, creating sublimation of the tissue. To remove the cyst with a novel technique that allows a good cosmetic result. Patients with clinical diagnosis of at least one epidermal cyst, aged between 18 and 70 years were enrolled. A standardized procedure was used. After administration of topical and sometimes local anesthesia (for cysts bigger than 1 cm), a tiny hole was created with plasma exeresis. The content of the cyst was then extruded and Micro Hartman Alligator Ear Forceps pulled out the loosened capsule. Twenty patients aged between 18 and 68 years were enrolled: 11 males (55%) and 9 females (45%). Twenty-eight cysts were successfully removed. The diameter ranged from 3 to 24 mm. No side effects were observed. The scar measured not more than 3 mm. This study suggests that plasma exeresis could represent a good and safe option to remove noninfected cysts on cosmetic areas, although further study is required.

Favre-Racouchot disease: systematic review and possible therapeutic strategies.

Favre-Racouchot disease (FRD) is a relatively common dermatosis induced by chronic sun exposure. FRD is clinically and histologically characterized by the presence of both comedones and cysts in the context of an elastotic degeneration of the dermis. Those lesions are mainly located in the face, especially in the malar and periorbital areas. Smoking and radiotherapy seem to play a role in the pathogenesis together with UV exposure. The disease affects predominantly the aged population and seems to be a problem of mainly aesthetic concern. No official guidelines are available for the treatment of FRD; most common therapeutic strategies are represented by topical retinoids and laser treatments. The goal of our review was to identify the principal clinical and epidemiological characteristics of FRD and to analyse all the therapeutic strategies available. We also focused our attention on the follow-up of this particular dermatosis. Our aim was therefore to suggest alternative possible strategies for both the treatment and the follow-up of these patients. Our data support the efficacy of carbon dioxide laser and topical retinoids in the setting of FRD, but we also suggest considering alternative treatments, such as plasma exeresis. We also recommend planning both a short-term and a long-term follow-up visit, as the majority of relapses is observed after 10-12 months.

Clinical and Confocal Microscopy Study of Plasma Exeresis for Nonsurgical Blepharoplasty of the Upper Eyelid: A Pilot Study.

Plasma exeresis is an evolving technique for nonsurgical treatment of several skin conditions. Reflectance confocal microscopy (RCM) is a noninvasive tool that allows the "in vivo" imaging of the skin. To evaluate the clinical improvement and collagen remodeling of the upper eyelid dermatochalasis after plasma exeresis. Ten patients were subjected to 3 interventions of plasma exeresis. Photographic and RCM images were acquired at T0 (baseline) and T1 (4-6 weeks after final plasma exeresis). Eyelid dermatochalasis was rated as absent, mild, moderate, and severe according to the facial laxity rating scale, at clinical images at T0 and T1. An expert RCM evaluator classified collagen according to the predominant pattern of reticulated, coarse, huddled, or curled at T0 and T1. Clinical improvement of 2.6 ratings was observed at clinical evaluation. Collagen was classified as long straight fibers in all cases, according to RCM images. Plasma exeresis in this pilot study shows promising remodeling effects on the collagen of the upper eyelid, as viewed by RCM, and clinically improved appearance for the patient cohort, without any serious adverse events. This study suggests that plasma exeresis could be a valid solution for eyelid dermatochalasis, but further studies are required.

Non Invasive Blepharoplasty with Plasma Exeresis (Plexr) Pre/Post Treatments

The following examination was directed for six months, in the Blepharoplasty and Non Invasive Eye Lid Surgery with Plexr. The objective has been the research of anesthesia in the zone of the eyelids by measuring different mixtures of analgesic creams. The investigation took place in 60 individuals. On these patients we practiced three unique sorts of anesthetic cream and analyzed the outcomes. In order to get the best outcome you need to apply a fair amount of anesthetic cream, but mostly the effect relies upon the responsiveness of every patient to skin sensitization. What follows are the researches that have been examined for three sorts of anesthetic creams available in pharmacies. Besides, a similar report took place in the recuperation technique following the use of Plexr in blepharoplasty, with and without make-up promptly after treatment. Research was practiced in 60 patients. We split patients into two segments: The principal group did not wear make-up amid the recuperation time frame, while the second did not use make-up until the punches drop.

Combination of Autologous Treatments for Non–Invasive Blepharoplasty and Non–Surgical Full Face Lift

Traditionally, the only way to improve the signs of aging and in general the ptosis of the face contour due to aging was the surgical lifting. The famous facelift. Based on the basic principles of face anatomy and surgical lifting, the HLH THERAPY (Hybrid Lifting Homologous) appeared. An alternative natural lifting treatment, where in a natural and autologous way, without changing the shape of the face or the characteristics we manage to go back in time and give a younger look. It is a bloodless treatment that gives the same results as surgical lifting, both in duration and appearance, but without the risk of distortion of characteristics or undesirable side effects. A full face lift also includes a blepharoplasty surgery. In this article we will analyze how we can have a full face lift with blepharoplasty, in a natural way, bloodless, without cuts or stiches. For the non- surgical blepharoplasty the technique that is used, in the well-known, Plasma Exeresis technique with the Plexr® device. HLH Therapy uses both, the Plasma exeresis technique using the PLEXR® microsurgical device and the autologous threads treatment using the needle shaping technique and the machine Vibrance. This parallel application of these two separate therapies (autologous threads with Needle Shaping Techniques and sublimation and shrinking of elastic fibers with the use of Plasma Exeresis in the same time) is the synthesis of the HLH methodology. We can say that it is the next step in soft surgery applications. The results so far show that the technique provides the results of a complete face lift, with only few days of recovery and no anaesthetic use. The treatment was first inspired by surgeon ophthalmologist Sotiris Tsioumas and was first developed by him after six years research and experience.

Autologous Threads and Plasma Exeresis Technique for Total Facial Reconstruction (Internal and External) - HLH Therapy

Currently, to bring a solution to the aging related factors surgical lifting was the only possible technique. Pyrosis is a disease, occurring due to aging that can be corrected by such techniques where the ptosis of the face contour is modified. This technique is known as the renowned facelift. Contemplating the basic assumptions of facial anatomy and surgical lifting, the HLH THERAPY (Hybrid Lifting Homologous) was recommended. An alternative common lifting treatment was introduced where configuration of the face or the component is maintained in a natural and autologous way without altering it in order to restore the youthful look. The treatment is similar to the surgical lifting which does not have open cut procedures as in terms of time and look. There is no risk of fabrication of characteristic or unwanted side effects. A full-face lift also constitutes a blepharoplasty surgery. In this article we will evaluate how we can have a full face lift with blepharoplasty, in a universal way, bloodless, without any cuts or stiches .For the non-surgical blepharoplasty, the technique that is commonly used is known as Plasma Exeresis technique with the Plexr® device. The Plasma exeresis technique by using the PLEXR® micros urgical device and the autologous threads treatment by using the needle shaping technique and the machine Vibrance are applied and included in the HLH Therapy. The treatment shows the circumstantial development in the thickness of the elastic fibers, which reduce their length and divert their direction from vertical to horizontal (by Needle Shaping), while concurrent with the Plasma exeresis Techniques and the machine Plexr®, we have barrier of sufficient skin. Plexr® do not penetrate the basement membrane and it upholds but also restraints the corneo cells, shrinking of the elastic fibers and at this stage it balances the autologous thread. The co-extensive activity of these two therapies (autologous threads with Needle Shaping Techniques and sublimation and shrinking of elastic fibers using Plasma Exeresis concurrently) is the structure of the HLH methodology. We can state that soft surgery applications are the following steps to the ongoing process. The consequences are remarkable within few days of recovery without any anesthetic use.