Purpose. To evaluate the effects of the plant density and fertilizer dose on the yield and thousand seed weight in F1 confectionary sunflower hybrids. Methods. Field, laboratory and mathematical statistical methods were used. Results. The average yield of confectionery sunflower hybrids grown at a density of 28,600 plants/ha exceeded their yield at a density of 20,400 plants/ha by 0.01–0.43 t/ha, depending on the study year and fertilizer dose. The average thousand seed weight at the density of 20,400 plants/ha exceeded that at the density of 28,600 plants/ha by 6.0–14.8 g. The greatest increase in the yield and thousand seed weight was achieved when fertilizers were applied at a dose of N45P45K45: +0.21 t/ha and +6.5 g to the control (without fertilizers), respectively, at the density of 28,600 plants/ha; +0.18 t/ha and +5.4 g to the control, respectively, at the density of 20,400 plants/ ha. The maximum seed yield was produced by hybrid Forsazh: 3.97 t/ha (2016, 28,600 plants/ ha, N45P45K45). Confectionery hybrids Hudvin and Nasoloda had the maximum values of the thousand seed weight: 123.0 and 121.2 g, respectively (2018, 20,400 plants/ha, N45P45K45), which exceeded the thousand seed weight of the check large-fruited variety by 7.2 and 5.4 g, respectively. In the dry year (2017), the thousand seed weight in Hudvin and Nasoloda grown at the density of 20,400 plants/ha was higher than 95.6 g. In the wet year (2020), the thousand seed weight in Hudvin and Nasoloda, even at the density of 57,100 plants/ha, amounted to 88.6–92.5 g. Conclusions. The seed yield and thousand seed weight of the confectionary sunflower hybrids are significantly influenced by plant density, fertilizer dose and weather conditions during the growing period. The highest yield and thousand seed weight were recorded when fertilizers were applied at the dose of N45P45K45: 3.97 t/ha (at 28,600 plants/ha) and 123 g (at 20,400 plants/ha), respectively. The confectionery sunflower hybrids ensured high yields and high-quality confectionary seeds in Eastern Forest-Steppe of Ukraine.