Indonesia’s microclimate change issues base the big impending for inundation to happen when precipitation is too extraordinary in the area of soybean farming, which can give an influence soybean production. Inundation is a major difficulty in many parts of the entire world and soybeans are delicate to inundation. The use of plant growth regulators (PGR) can respond to soybean plant alteration to inundation stresses. This research was conducted from June to September 2020 in the irrigated rice fields of Kwala Sememe Deli Tua, Deli Serdang District, using a Randomized Block Design (RBD) one factor consisting of Anjasmoro, Grobongan, Deja 1, Devon 1 varieties with 96 h of inundation, with the application of PGR GA3 and Salicylic Acid. The parameters observed were plant height, number of leaves, and number of adventitious roots. The results showed that inundation had an effect on the cultivar used. Anjasmoro cultivar showed the best response to plant height variables while Grobogan cultivar showed the opposite response.