Abstract Chemical coatings on seed are commonly used in the grain sorghum seed industry to protect plants against herbicide damage and to inoculate young plants against certain disease. In this study, grain sorghum grown from seed safened with CGA‐92194 ([(l,3‐dioxolo‐2‐yl‐methoxy)‐imino] benzene‐acetonitrile} against injury from the herbicide, metolachlor, was studied for seedling vigor, seedling emergence, plant growth, and Fe‐deficiency chlorosis. Other seed was additionally treated with a systemic fungicide [(Metalaxyl:N‐(2,6‐dimethylphenyl)‐N‐(methoxyacetyl) alaminemethyl ester)] for control of systemic downy mildew and diseases caused by soilborne Phythium and Phytophthora spp. The experiment was conducted on Fe‐sufficient and Fe‐deficient soils. CGA‐92194 safened seed showed a slight reduction in stand on Goliad sandy loam soils (Fe‐sufficient), while the addition of the fungicide together with the herbicide safener reduced plant emergence by 39%. Sorghum emergence was generally not affected by see...