The article provides information about the biofertilizer preparation "Fulfohumat "Ivan Ovsinsky"® and the results of its use against cotton wilt. When processing cotton with a preparation with a norm of 500 ml per hectare in the conditions of takyrovid soils of the southern regions of the Republic of Uzbekistan (Kashkadarya region), the incidence of cotton fusarium wilt decreases by 1.6 times, the efficiency is 83.9%, the number of dried plants decreases by 2.9 times, the weight of raw one box increases by 5.6%, the weight of 1000 seeds by 0.33% and fiber length by 1.5%. The yarn spinning coefficient has increased from a medium degree (130-140) to a high degree (140-149) or from a low degree (120-129) to a very high degree (150). The micronair of cotton fiber in treated plants has become softer — from 0.04 to 0.46 degrees. After treatment with the drug, the fibers in sick plants were lengthened by 0.016–0.018 inches, and in healthy plants the fiber length was shortened by 0.009 inches.