Thailand constantly faces the problem of water scarcity, resulting from an imbalance between available water supply and increasing water demand for economic and community expansion, as well as climate change. To address this shortage, wastewater reclamation is being planned and implemented throughout the country, along with a 20-year, long-term integrated water resource management plan. Significant opportunities from municipal wastewater treatment plants (WWTPs) are dependent on the following factors: the establishment of a reuse water framework and a tangible target for treated wastewater set by local government authorities; widespread recognition and adaptation of wastewater reuse measures in the agriculture, industry, tourism and service sectors regarding climate change and water stress; and the implementation of joint investment water reuse projects between private and government agencies. However, wastewater reclamation faces some significant challenges, specifically: the limitations of regulation and monitoring for specific reuse purposes; a lack of public confidence in the water quality; the limited commercial development of reclaimed wastewater research; and difficulties in self-sustaining business models through adapting circular economy principles. This study aims to provide an overview of the wastewater reclamation, present research trends, currently operating WWTPs as well as opportunities and challenges to speed up water reuse activities in Thailand.