We read with interest the article by Lakhan and colleagues,1 which showed the high prevalence and worsening of geriatric syndrome during acute care hospitalization. Because falls, incontinence, impairment in activities of daily living (ADLs), and other geriatric syndrome components increase the care burden and limit discharge planning in acute care hospitals, geriatric syndrome might cause prolonged hospital stays. A prolonged hospital stay is one of the major determinants of medical cost and is thus a serious problem in geriatric medicine. Previous studies have shown that clinical events during hospitalization,2, 3 basic ADLs,4 and nonmedical factors such as delayed transfer to a nursing facility or disagreement on the discharge plan among family members5 are risk factors for prolonged hospital stay. Furthermore, because older adults have multiple comorbid conditions and are susceptible to adverse drug reactions (ADRs), these factors might be related to length of hospital stay. To test this hypothesis, the association between geriatric conditions such as geriatric syndrome, ADLs, and ADRs and prolonged hospital stay were comprehensively investigated using the database of the geriatric ward of the University of Tokyo Hospital from 1995 to 2010. The ethics committee of the Graduate School of Medicine, University of Tokyo approved this study. All records of patients aged 65 and older from 1995 to 2010 were reviewed. Data on length of stay, acute hospitalization, ADRs, body mass index (BMI), number of diseases and drugs, geriatric syndrome, and Barthel Index were collected. Twenty-three components of geriatric syndrome such as falls, cognitive impairment, urinary incontinence, constipation, and insomnia were included in the analysis. Records lacking information on any of the variables were excluded. Cases of scheduled short-term hospitalization were excluded. Finally, the records of 1,616 patients were analyzed (mean age 78.3 ± 7.0, 52% male). All data were obtained soon after admission. Values are expressed as means ± standard deviations and were analyzed using JMP version 9.0.2 (SAS Institute, Inc., Cary, NC). P < .05 was considered statistically significant. Mean length of stay was 27.3 ± 22.6 days (range 1–322 days). The results of univariate and multivariate analyses for length of stay are shown in Table 1. Multiple stepwise regression analysis showed that ADRs, number of diseases, and number of geriatric syndrome components were positively associated with longer hospital stay, whereas age, BMI, and Barthel Index were negatively associated. The number of geriatric syndrome components was significantly associated with hospital stay independent of number of diseases. The present analysis demonstrated that geriatric factors such as ADRs, multiple diseases, low BMI, ADL dependence, and number of geriatric syndrome components were associated with longer hospital stay in a large group. The finding that ADRs are a risk for prolonged hospital stay is consistent with a previous report,6 and ADL dependence has been reported as a risk in a smaller group.4 Furthermore, the number of geriatric syndrome components and undernutrition were risk factors for prolonged hospital stay in a large-scale study. Frailty, which is also known to be a risk factor,7 was not examined independently in the present study, but ADL dependence and undernutrition, both of which are major components of frailty, were found to be risk factors, so it is reasonable to assume that frailty was associated with length of hospital stay in the current cohort as well. The present study revealed that the accumulation of geriatric syndrome components was a risk factor for prolonged hospital stay independent of multiple diseases and, presumably, frailty. Thus, geriatric syndrome should be comprehensively managed during hospitalization. The reason for the negative association between age and length of stay is unclear, but the presence of young-old patients with disability or complicated conditions on the geriatric ward might have influenced the results. In summary, the present study provides new insight into the significance of geriatric conditions in relation to prolonged hospital stay in older adults. ADL dependence, undernutrition, ADRs, and geriatric syndrome should be carefully assessed and interventions provided when caring for older inpatients. Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this paper. Author Contributions: TK: acquisition of subjects and data analysis, interpretation of data, and drafting of manuscript. MA: coordinator of study concept and design, and study supervision. YK, KY, and HY: acquisition of subjects and data. ME: data analysis and interpretation of data. YO: study supervision. Sponsor's Role: The sponsors had no role in the design, methods, data collections, analysis, and preparation of this paper.
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