The wave activity flux representing the energy propagation direction of planetary Rossby wave generally originates from a large wave source area. This study investigates the interdecadal variability and formation mechanism of Rossby wave source over the Tibetan Plateau (TP-RWS) and its impact on the atmospheric circulation and precipitation pattern in East Asia based on the ERA-20C reanalysis dataset in summer (June–July–August) during 1900 to 2010. Results show that the region with the maximum variabilities of Rossby wave source (RWS) in the past 110 years appears over the Tibetan Plateau (TP) during boreal summer, and the TP-RWS shows prominent characteristics of interdecadal oscillation. Secondly, the TP-RWS is mainly composed of the vortex stretching term (RWS-S1) and the absolute vorticity advection term (RWS-S2). The interdecadal TP-RWS is a synergistic result of the snow cover over northwestern TP associated with the RWS-S1, and the deep convection over southeastern TP associated with the RWS-S2. Furthermore, the interdecadal TP-RWS can lead to an alternatively positive and negative pattern of geopotential height anomalies from the northwestern TP to the North Pacific, which has a great climate effect on the precipitation in Huang-huai River Basin, South Korea and Japan Island. Under the guidance of the anomalous cyclonic circulation in East Asia, the prevailing southerly and easterly winds occur over the West Pacific and the Huang-huai River Basin, which lead to the water vapor convergence and upward movement at middle and lower troposphere.