The planetary roller screw mechanism (PRSM) faces an ever-increasing precision transmission demand in current advanced equipment. The relationship between machining errors and transmission accuracy remains elusive due to the over-simplified physical models and small-sample experimental datasets. This work proposes a physics-informed and data-driven hybrid strategy for PRSM transmission accuracy evaluation and tolerance optimization. In the physical model, a PRSM transmission accuracy model is developed to calculate transmission error that considers 16 machining errors in eccentric, nominal diameter, pitch, flank angle, and roller consistency. In the dataset establishment, thread profile measurements and dynamic leadscrew inspections are conducted for the machining error and transmission accuracy data acquisition. A data augmentation approach combining the physical model with the generative adversarial network is utilized to predict travel deviation, variations, and axial backlash and estimate machining error contribution with the small-sample experimental dataset. It is firstly found that the roller consistency of nominal diameter significantly affects PRSM travel variation V2π with a 17.3 % importance value. With the developed framework, the key tolerances for screw, roller, nut, and roller consistency are optimized toward a typical precision transmission requirement using the non-dominated sorting genetic algorithm. It also provides a tolerance grade recommendation table with PRSM transmission accuracy level in engineering practice.