Planetary Health Research Research Articles

Planetary Health Research Digest

Planetary Health Research Digest

Planetary health in action: developing a heatwave vulnerability tool for primary care.

Heatwaves are becoming longer and more frequent. Despite the availability of open environmental data, little is operable and formatted for primary care use. Create a user-friendly online mapping tool to assess the vulnerability of communities to heatwaves for use by primary care practitioners. This study questioned what knowledge needed to be deployed, who needed to participate and how the knowledge should be shared. A participatory action-research project based on knowledge mobilization in France as part of the Green Data for Health Challenge. Knowledge was summarized on the factors most affecting heatwave vulnerability in a collaborative process, enabling a consensus on data variables and mobilised content for the online tool. Purposive sampling included primary care stakeholders with Regional Health Agencies (ARS), Public Health France, and data scientists. Nineteen participants participated in ten co-construction workshops, a brainstorming carousel strategy and five weekly co-design meetings between December 2022 and June 2023. The heatwave vulnerability variable was constructed using surface temperature, social deprivation, vegetation coverage, and presence of air conditioning equipment. Identified experts mobilized data on the national composite indicator at the communal level for heatwave morbidity. There is no standard platform for sharing environmental data in France. This co-creation study offers a new approach to incorporating environmental data on heatwaves into primary care consultations. We demonstrate the importance of knowledge mobilisation in primary care to bridge the research-practice gap. Integrating primary care records with environmental data may promote broader applications for planetary health research.

Conotruncal Heart Defects: A Narrative Review of Molecular Genetics, Genomics Research and Innovation.

Congenital heart defects (CHDs) are most prevalent cardiac defects that occur at birth, leading to significant neonatal mortality and morbidity, especially in the developing nations. Among the CHDs, conotruncal heart defects (CTDs) are particularly noteworthy, comprising a significant portion of congenital cardiac anomalies. While advances in imaging and surgical techniques have improved the diagnosis, prognosis, and management of CTDs, their molecular genetics and genomic substrates remain incompletely understood. This expert review covers the recent advances from January 2016 onward and examines the complexities surrounding the genetic etiologies, prevalence, embryology, diagnosis, and clinical management of CTDs. We also emphasize the known copy number variants and single nucleotide variants associated with CTDs, along with the current planetary health research efforts aimed at CTDs in large cohort studies. In all, this comprehensive narrative review of molecular genetics and genomics research and innovation on CTDs draws from and highlights selected works from around the world and offers new ideas for advances in CTD diagnosis, precision medicine interventions, and accurate assessment of prognosis and recurrence risks.

A Quadruple Revolution: Deciphering Biological Complexity with Artificial Intelligence, Multiomics, Precision Medicine, and Planetary Health.

A quiet quadruple revolution has been in the making in systems science with convergence of (1) artificial intelligence, machine learning, and other digital technologies; (2) multiomics big data integration; (3) growing interest in the "variability science" of precision/personalized medicine that aims to account for patient-to-patient and between-population differences in disease susceptibilities and responses to health interventions such as drugs, nutrition, vaccines, and radiation; and (4) planetary health scholarship that both scales up and integrates biological, clinical, and ecological contexts of health and disease. Against this overarching background, this article presents and highlights some of the salient challenges and prospects of multiomics research, emphasizing the attendant pivotal role of systems medicine and systems biology. In addition, we emphasize the rapidly growing importance of planetary health research for systems medicine, particularly amid climate emergency, ecological degradation, and loss of planetary biodiversity. Looking ahead, we anticipate that the integration and utilization of multiomics big data and artificial intelligence will drive further progress in systems medicine and systems biology, heralding a promising future for both human and planetary health.

Coming together as a whole: lessons from connecting across sectors, cultures, and contexts to elevate efforts for planetary health

BackgroundAddressing complex and interconnected ecological, social, and health issues necessitates upstream, solutions-oriented, and whole-systems thinking. Specifically, exploring what it means to live in reciprocity with the planet and all living systems, now and for generations to come, can have a crucial role in advancing planetary health. MethodsIn this presentation, we show findings from four gatherings that we co-designed and co-hosted to connect communities, lands, waters, climate, and health. We draw lessons from two events in the Cowichan watershed (co-hosted by Cowichan Tribes) and the Stellako and Nechako watersheds (co-hosted by Stellat'en First Nation) that were co-designed with the ECHO Network. These gatherings brought together youth, Indigenous leaders, researchers, and health, community, and environmental decision-makers across British Columbia to learn how to address connected health, environmental, and community concerns. We supplement these findings with insights from two co-hosted conversations, that connected five continents and more than 40 countries, each enabling 24 h of continuous dialogue on the theme of working together for a healthy, just, and sustainable planet. FindingsGatherings took place between Oct 12, 2022, and Dec 1, 2023. These gatherings each provided lessons about how Indigenous-led, integrative approaches that connect the health of people to lands, waters, and ecosystems can elevate and enhance our work and scholarship to address ecological, social, and health issues. Specifically, initiatives co-designed in this way help overcome challenges that arise when addressing boundary-crossing, intersectional and intersectoral issues at the nexus of climate, public health, and planetary health. Our findings include insights into strengthening research and public health capacity for integrative approaches to complex issues that are relevant to place-based contexts and have implications and applications for planetary health. InterpretationOur presentation summarises how these gatherings—each of which were fuelled by a sense of love for the planet, each other, and future generations—have progressed intersectoral, intergenerational, boundary-crossing, and transformative approaches to planetary health. These insights help guide future directions for planetary health research, practice, and policy. FundingThe Canadian Institute of Health Research Environment (IP4150712), Michael Smith Health Research BC (RA-2022-2872), and Vancouver Foundation (FOI19-1781).

Giant Virus Global Proteomics Innovation: Comparative Evaluation of In-Gel and In-Solution Digestion Methods.

With their unusually large genome and particle sizes, giant viruses (GVs) defy the conventional definition of viruses. Although most GVs isolated infect unicellular protozoans, such as amoeba, studies in the last decade have established their much wider prevalence infecting most eukaryotic supergroups and some giant viral families with the potential to be human pathogens. Their complexity, almost autonomous life cycle, and enigmatic evolution necessitate the study of GVs. The accurate assessment of GV proteome is a veritable challenge. We have compared the coverage of global protein identification using different methods for GVs isolated in Mumbai, Mimivirus Bombay (MVB), Powai Lake Megavirus (PLMV), and Kurlavirus (KV), along with two previously studied GVs, Acanthamoeba polyphaga Mimivirus (APMV) and Marseillevirus (MV). Our study shows that the simultaneous use of in-gel and in-solution digestion methods can significantly increase the coverage of protein identification in the global proteome analysis of purified GV particles. Combining the two methods of analyses, we identified an additional 72 proteins in APMV and 114 in MV compared with what have been previously reported. Similarly, proteomes of MVB, PLMV, and KV were analyzed, and a total of 242 proteins in MVB, 287 proteins in PLMV, and 174 proteins in KV were identified. Our results suggest that a combined methodology of in-gel and in-solution methods is more efficient and opens up new avenues for innovation in global proteome analysis of GVs. Future planetary health research on GVs can benefit from consideration of a broader range of proteomics methodologies as illustrated by the present study.

Towards a practice framework for transdisciplinary collaboration in planetary health

Abstract Non-Technical Summary Despite growing recognition of the importance of transdisciplinary research in addressing complex sustainability challenges, in practice it has been much hampered by persistent inequities, power disparities, and epistemological disconnect. Planetary health as an emerging field offers a unique lens highlighting the need for knowledge integration across the environment, health, and development (EHD) nexus. Drawing upon extensive analyses, including a meta-analysis of existing transdisciplinary frameworks, a literature review of practices in these fields, and a case study of a planetary health action research project in Indonesia and Fiji, we propose a framework to guide the design and implementation of transdisciplinary research. Technical Summary The proposed framework was iteratively designed, starting with existing frameworks, complemented by findings and practice recommendations from a literature review of 36 publications of recent transdisciplinary practices in the EHD fields and an in-depth case study of a planetary health research from Indonesian perspectives. The practice framework focuses on the stakeholder collaboration process, and emphasizes reflexivity and co-learning throughout all research phases: initiation (co-design); implementation (adaptive co-management), and monitoring and refinement (co-monitoring). Foundational considerations for stakeholder engagement could inform process design by reflecting on stakeholder contributions, interactions, integration, and expected outcomes. As suggested by development studies, and implicitly agreed upon but insufficiently elaborated within environment and health, attention to the local context of the research, mapping of power dynamics, and the values of equity and inclusivity are pertinent if research is to produce credible, relevant, and legitimate knowledge and outcomes. A renewed focus on addressing power equities can help ensure stakeholders' perspectives and interests are equally valued and potential solutions are not inadvertently excluded as a legacy of systemic power imbalance. The practice framework is most effectively applied in the initial process co-design, by process initiators and funders assessing proposals for international transdisciplinary research in power-diverse settings or resource-poor contexts. Social Media Summary How can researchers across diverse fields collaborate with renewed focus on power inequities to accelerate progress towards the Sustainable Development Goals?

CoVProt: Toward a Mass Spectrometry Data Portal for COVID-19 Proteomics Research and Development.

The coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc globally. Beyond the pandemic, the long-term effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in multiple organ systems are yet to be deciphered. This calls for continued systems science research. Moreover, the host response to SARS-CoV-2 varies person-to-person and gives rise to different degrees of morbidity and mortality. Mass spectrometry (MS) has been a proven asset in studies of the SARS-CoV-2 from an omics systems science lens. To strengthen the proteomics research dedicated to COVID-19, we introduce here a web-based portal, CoVProt. The portal is work in progress and aims for a comprehensive curation of MS-based proteomics data of COVID-19 clinical samples for deep proteomic investigations, data visualization, and easy data accessibility for life sciences innovations and planetary health research community. Currently, CoVProt contains information on 2725 different proteins and 37,125 different peptides from six data sets covering a total of 202 clinical samples. Moreover, all pertinent data sets extracted from the literature have been reanalyzed using a common analysis pipeline developed by combining multiple tools. Going forward, we anticipate that the CoVProt portal will also provide access to the clinical parameters of the patients. The CoVProt (v1.0) portal addresses an existing significant gap to study COVID-19 host proteomics, which, to the best of our knowledge, is the first effort in this direction. We believe that CoVProt is poised to make contributions as a community resource for proteomic applications and aims to broadly support clinical studies to facilitate the discovery of COVID-19 biomarkers and therapeutics with translational potential.

Bringing Social Science Into Critical Zone Science: Exploring Smallholder Farmers' Learning Preferences in Chinese Human‐Modified Critical Zones

AbstractThere is a growing global emphasis on sustainable agriculture to reduce human impacts and improve delivery of Sustainable Development Goals (SDGs). With increasing investment in critical zone observatories (CZOs), it becomes important to understand how sustainable agricultural knowledge is produced, shared and used between different groups including farmers, scientists and government. To explore these issues, scientists leading the knowledge exchange (KE) component of a China‐UK CZO program studied three farming regions with contrasting geologies and varying economic levels, using a practice‐based research method. We demonstrate how additional funding for social science research allowed us to understand how farmers access and share farming knowledge through bonding, bridging and linking networks, and how this varies spatially, using interviews and survey questionnaires. Knowledge flows, barriers and opportunities for designing locally suited two‐way KE activities were identified. First, we highlight the need for a more locally, socially embedded and reflexive approach to build trust and better address pressing local environmental challenges. Second, we show how social science can usefully inform KE for collaborative, international development science, to draw on local knowledge, promote research impacts and capacity building while avoiding knowledge mismatches. Lastly, a blueprint for the design and funding of future CZOs, social‐ecological and planetary health research agendas that combine science, social science, local knowledge and KE is presented, including the need for substantive social science research to take place in addition to science research in human‐modified landscapes—enabling the CZ science to be better grounded in, informed by and useful to local communities.

Achieving Sustainable Earth Futures in the Anthropocene by Including Local Communities in Critical Zone Science

AbstractCritical Zone Science (CZS) explores the deep evolution of landscapes from the base of the groundwater or the saprolite‐rock interface to the top of vegetation, the zone that supports all terrestrial life. Here we propose a framework for CZS to evolve further as a discipline, building on 1st generation CZOs in natural systems and 2nd generation CZOs in human‐modified systems, to incorporate human behaviour for more holistic understanding in a 3rd generation of CZOs. This concept was tested in the China‐UK CZO programme (2016–2020) that established four CZOs across China on different lithologies. Beyond conventional CZO insights into soil resources, biogeochemical cycling and hydrology across scales, surveys of farmers and local government officials led to insights into human‐environment interactions and key pressures affecting the socio‐economic livelihoods of local farmers. These learnings combined with the CZS data identified knowledge exchange (KE) opportunities to unravel diverse factors within the Land‐Water‐Food Nexus, that could directly improve local livelihoods and environmental conditions, such as reduction in fertilizer use, contributing toward Sustainable Development Goals (SDGs) and environmental policies. Through two‐way local KE, the local cultural context and socio‐economic considerations were more readily apparent alongside the environmental rationale for policy and local action to improve the sustainability of farming practices. Seeking solutions to understand and remediate CZ degradation caused by human‐decision making requires the co‐design of CZS that foregrounds human behavior and the opinions of those living in human modified CZOs. We show how a new transdisciplinary CZO approach for sustainable Earth futures can improve alignment of research with the practical needs of communities in stressed environments and their governments, supporting social‐ecological and planetary health research agendas and improving capacity to achieve SDGs.

Avengers, assemble the literature! A multi‐study review of consumption, environmental values, and planetary health research

AbstractMother Earth is dying. Humanity needs to step up. Otherwise, the planet we call home will soon be uninhabitable. The destiny of our planet inarguably depends on consumers, as their choices have the power to turn them into eco‐superheroes (sustainable consumption) or eco‐villains (unsustainable consumption). This article aims to review the current progress of consumption research and propose strategies to inspire consumers to embrace their inner eco‐warrior spirit, fostering sustainable behavior that protects the environment and supports human well‐being. To achieve this, this article employs an integrative approach, merging a meta‐perspective on theoretical development with a multi‐study methodological approach. Harnessing the power of scientometrics, this article delivers meta‐insights from a multi‐study analysis on consumption trends in relation to environmental values (micro‐perspective; Study 1) and planetary health (macro‐perspective; Study 2). These findings pave the way for future research and intervention strategies designed to nurture ecological sustainability and unleash the eco‐warrior in every consumer.

One Health and planetary health research: leveraging differences to grow together

The COVID-19 pandemic and the anthropogenic impact on Earth's life-support systems and planetary boundaries have reinvigorated the One Health and planetary health concepts, propelling them to the forefront of the global health and sustainable development agendas. Although both concepts build on equivalent systemic principles, there is an ongoing debate and emerging confusion around their differences and application areas.1–3

Tackling AMR: A Call for a(n Even) More Integrated and Transdisciplinary Approach between Planetary Health and Earth Scientists

Antibiotic resistance is a pressing global, one health and planetary health challenge. Links between climate change, antibiotic use, and the emergence of antibiotic resistance have been well documented, but less attention has been given to the impact(s) of earth systems on specific bacterial livestock diseases at a more granular level. Understanding the precise impacts of climate change on livestock health—and in turn the use of antibiotics to address that ill-health—is important in providing an evidence base from which to tackle such impacts and to develop practical, implementable, and locally acceptable solutions within and beyond current antibiotic stewardship programs. In this paper, we set out the case for better integration of earth scientists and their specific disciplinary skill set (specifically, problem-solving with incomplete/fragmentary data; the ability to work across four dimensions and at the interface between the present and deep/geological time) into planetary health research. Then, using a case study from our own research, we discuss a methodology that makes use of risk mapping, a common methodology in earth science but less frequently used in health science, to map disease risk against changing climatic conditions at a granular level. The aim of this exercise is to argue that, by enabling livestock farmers, veterinarians, and animal health observatories to better predict future disease risk and risk impacts based on predicted future climate conditions, earth science can help to provide an evidence base from which to influence policy and develop mitigations. Our example—of climate conditions’ impact on livestock health in Karnataka, India—clearly evidences the benefit of integrating earth scientists into planetary health research.

Planetary health research: insights from The Lancet Planetary Health original articles

Abstract Background In 2017, the Lancet group launched The Lancet Planetary Health to promote the dissemination of research conducted in this field. Planetary health was also extensively discussed during the World Congress on Public Health 2020, which underlines the strategic importance recognized to this topic by experts and researchers active in public health at an international level. The aim was to investigate the role of public health university departments in the field of planetary health. Methods The Lancet Planetary Health database was queried from the inception to February 2021, to retrieve original articles or reviews whose first and/or last author was affiliated to a University Department of Public Health worldwide. We used the twenty-six EUPHA operational sections to define the research areas of the identified articles. The following data were extracted: study design, EUPHA area, research question, topic, identified gaps in the literature, and key concepts. Results Out of 543 entries, 44 original articles and reviews were included. Thirty-two percent studies were conducted in Asia, 20% in America, 13% in Europe, 8% in Oceania, 4% in Africa while 23% in a multicentric global context. The area investigated was mainly environmental and health (68%) followed by infectious disease control (14%). Collaboration across different disciplines is highly present in the authorships. Regarding the study design, 30% of the included articles were cohort studies. Conclusions From 2017 till February 2021, the number of studies performed by public health researchers published on The Lancet Planetary Health is gradually increasing. Since published articles take advantage of the typical research methods and topics of public health and environmental health research, public health university departments can contribute to planetary health science if they seek transdisciplinary collaboration and adopt a planetary health vision.

Planetary health diplomacy and transdisciplinary research

Abstract Given the urgent need for multilateral action for planetary health, the scope of planetary health research must be broadened. Key challenges are currently addressed through disconnected approaches and fragmented policy making. Planetary health is an integrative approach that can enhance synergies across multiple fragmented agendas, notably related to health, environment, human rights, and security. It is high time to boost an overlooked area: planetary health diplomacy. This involves measuring progress beyond gross domestic product, broadening the understanding of security to include planetary health, and reforming international organisations to ensure the protection of a rule-based international order. Efforts to address them lack a truly holistic narrative. The science of planetary health goes beyond the currently politicised climate change agenda. So far, planetary health studies have privileged natural science in order to become more impactful. However, the insights gained through this work deserve to be translated into actionable policies for decision makers. More social scientists are therefore needed in this process. Scholars of international relations are under-represented in the planetary health community. The absence of political scientists, lawyers, foreign policy experts, diplomats, and civil servants who are committed to translating planetary health knowledge into effective action comes at a high cost. Policy decisions are being reshaped in the context of evolving pandemic recovery planning, and strategies to advance planetary health that do not take account of unfolding shifts in global power relations are doomed to fail. With only a decade remaining to shift gears towards achieving the SDGs, there is no time to spare. de Paula, N. (2021). Planetary health diplomacy: a call to action. The Lancet. Planetary Health, 5(1), e8-e9. doi:10.1016/S2542-5196(20)30300-4.

Bouncing forward: Knowledge Translation for policy making in response to the COVID-19 and climate change co-emergencies

BACKGROUND AND AIM: UN Secretary General, Antonio Guterres claimed early on in the pandemic that, without appropriate actions from multiple sectors, the social and economic devastation caused by climate change will be greater than that of COVID-19 (Fearnow, 2020). Climate change exacerbates existing health inequalities and has been described as “the greatest global health opportunity of the 21st century” (Watts et al., 2016). These inequalities are being further compounded by the pandemic. It is important that public health professionals are involved when designing mitigation and adaptation strategies, in partnership with policy makers and other stakeholders (Costello et al., 2009). METHODS: The webinar series “Learning and Relearning for Planetary Health: Lessons from a Pandemic” offers a collection of session recordings and presentation documents. This webinar series is a product of the SFU Planetary Health research group, along with scholars, industry professionals, community advocates and practitioners. Between April 15, 2020 and June 24, 2020, the presenters covered a range of topics regarding the relationship between the COVID-19 pandemic, planetary health, climate change and human health (in eleven sessions). The webinars explored policy options to “bounce forward and not back” into a post-COVID future; focusing on actions that transform the way we live and improve health for all, as we face the overarching threat of climate change. RESULTS:Knowledge Translation is the process of sharing research findings to multiple stakeholders in order to inform policy decisions. In order to broaden the learning of non-academic audiences, we have created a toolkit that presents key discussion points and recommendations from the webinars in a variety of formats. CONCLUSIONS:The toolkit is also a platform to communicate climate action opportunities and strategies emerging from the COVID-19 pandemic to policy makers. The toolkit includes policy briefs, a webpage, infographics, and op-eds that expand the reach of the knowledge presented in the webinar series. KEYWORDS: Climate, Policy and Practice, COVID-19, Knowledge Translation

The Application of \u2018Elite Interviewing\u2019 Methodology in Transdisciplinary Research: a Record of Process and Lessons Learned during a 3-Year Pilot in Urban Planetary Health Research

This paper sets out the rationale and process for the interviewing methodology utilized during a 3-year research pilot, ‘Moving Health Upstream in Urban Development’ (UPSTREAM). The project had two primary aims: firstly, to attempt to value economically the health cost benefits associated with the quality of urban environments and secondly, to engage with those in control of urban development in the UK in order to determine what are the barriers to and opportunities for creating healthy urban environments, including those identified through the utilisation of economic valuation. Engagement at senior level with those who have most control over key facets of planning and development implementation—such as land disposal, investment, development delivery and planning permission—was central to the approach, which encompassed the adoption of ‘elite interviewing’, a method developed in the USA in the 1950s and used in the political sciences but relatively unutilized in the health and environmental sciences [1]. Two rounds of semi-structured interviews were undertaken with 15 senior decision-makers from the UK’s main urban development delivery agencies, both public and private. The ‘elite interviewing’ approach successfully enabled the UPSTREAM project to capture and analyse the information received from the interviewees, all of whom held influential or leadership posts in organisations that are important actors in the process of planning, developing and constructing the built environment in the UK. Having academic and practitioner research leads on an equal footing created some minor tensions, but it also appeared to strengthen the rigor of the approach through a broad knowledge of context ‘in-house’. This form of co-production at times challenged academic traditions in qualitative analysis, but it also appeared to build trust with interviewees and provided greater clarity of the real-world context under investigation. Findings from this study are written up in a separate paper.

Biomimetics provides lessons from nature for contemporary ways to improve human health.

Homo sapiens is currently living in serious disharmony with the rest of the natural world. For our species to survive, and for our well-being, we must gather knowledge from multiple perspectives and actively engage in studies of planetary health. The enormous diversity of species, one of the most striking aspects of life on our planet, provides a source of solutions that have been developed through evolution by natural selection by animals living in extreme environments. The food system is central to finding solutions; our current global eating patterns have a negative impact on human health, driven climate change and loss of biodiversity. We propose that the use of solutions derived from nature, an approach termed biomimetics, could mitigate the effects of a changing climate on planetary health as well as human health. For example, activation of the transcription factor Nrf2 may play a role in protecting animals living in extreme environments, or animals exposed to heat stress, pollution and pesticides. In order to meet these challenges, we call for the creation of novel interdisciplinary planetary health research teams.

Environmental Violence: A Tool for Planetary Health Research

Environmental Violence: A Tool for Planetary Health Research

Amplifying the voice of youth through planetary health films

Amplifying the voice of youth through planetary health films