Plane-parallel Ionization Chambers Research Articles

Bolus 3D printing for radiotherapy with conventional PLA, ABS and TPU filaments: Theoretical-experimental study

A theoretical-experimental study of the interaction of electron beams with 3 filaments conventionally used for 3D printing is presented in this paper. Pieces of polylactic acid (PLA), acrylonitrile butadiene styrene (ABS) and thermoplastic polyurethane (TPU) are studied using Monte Carlo simulation with Geant4 and experimental measurements with plane-parallel ionization chambers and radiochromic films. Using different printing parameters and computed tomography, the presence of air gaps and the uniformity in the bolus density made with the different materials are evaluated. The main parameters in the Percentage Depth Dose (PDDs) are determined, the manufacturing process is standardized and the printing profiles are generated for each of the materials in order to obtain uniform attenuation characteristics in the pieces and improve adaptation to irregular anatomical areas.

Experimental investigation of the effective point of measurement for plane-parallel chambers used in electron beam dosimetry.

In this study, the effective point of measurement (EPOM) for plane-parallel ionization chambers in clinical high-energy electron beams was determined experimentally. Previous studies have reported that the EPOM of plane-parallel chambers is shifted several tens of millimeters downstream from the inner surface of the entrance window to the cavity. These findings were based on the Monte Carlo (MC) simulation, and few experimental studies have been performed. Thus, additional experimental validations of the reported EPOMs were required. In this study, we investigated the EPOMs of three plane-parallel chambers (NACP-02, Roos and Advanced Markus) for clinical electron beams. The EPOMs were determined by comparing the measured percentage depth-dose (PDD) of the plane-parallel chambers and the PDD obtained using the microDiamond detector. The optimal shift to the EPOM was energy-dependent. The determined EPOM showed no chamber-to-chamber variation, thereby allowing the use of a single value. The mean optimal shifts were 0.104±0.011, 0.040±0.012, and 0.012±0.009cm for NACP-02, Roos, and Advanced Markus, respectively. These values are valid in the R50 range from 2.40 to 8.82cm, which correspond to 6-22 MeV. Roos and Advanced Markus exhibited similar results to those of the previous studies, but NACP-02 showed a larger shift. This is probably due to the uncertainty of the entrance window of NACP-02. Therefore, it is necessary to carefully consider where the optimal EPOM is located when using this chamber.

Development of a 3D printing process of bolus using BolusCM material for radiotherapy with electrons

This work presents the optimized parameters of 3D printing for print bolus using BolusCM material. Printing parameters were selected of the homogeneity and absence of air gaps. The dosimetric features of printed bolus were measured with a plane-parallel ionization chamber and EBT3 radiochromic film. Measured features were compared with those estimated with Monte Carlo methods. BolusCM shows good characteristics to be used as bolus material in radiotherapy with electrons, where the printing process allows personalizing the bolus in function of patient characteristics. The material low-cost, the 3D printing and the dosimetric features are few of the advantages of using BolusCM material in radiotherapy with electrons in skin cancer treatment.

Low-density 3D-printed boluses with honeycomb infill in radiotherapy

PurposeDosimetric characteristics of 3D-printed plates using different infill percentage and materials was the purpose of our study. MethodsTest plates with 5%, 10%, 15% and 20% honeycomb structure infill were fabricated using TPU and PLA polymers. The Hounsfield unit distribution was determined using a Python script. Percentage Depth Dose (PDD) distribution in the build-up region was measured with the Markus plane-parallel ionization chamber for an open 10x10 cm2 field of 6 MV. PDD was measured at a depth of 1 mm, 5 mm, 10 mm and 15 mm. Measurements were compared with Eclipse treatment planning system calculations using AAA and Acuros XB algorithms. ResultsThe mean HU for CT scans of 3D-printed TPU plates increased with percentage infill increase from −739 HU for 5% to −399 HU for 20%. Differences between the average HU for TPU and PLA did not exceed 2% for all percentage infills. Even using a plate with the lowest infill PDD at 1 mm depth increase from 44.7% (without a plate) to 76.9% for TPU and 76.6% for PLA. Infill percentage did not affect the dose at depths greater than 5 mm. Differences between measurements and TPS calculations were less than 4.1% for both materials, regardless of the infill percentage and depth. ConclusionsThe use of 3D-printed light boluses increases the dose in the build-up region, which was shown based on the dosimetric measurements and TPS calculations.

OC-0928 Comparison of cylindrical and plane-parallel ionization chambers in continuous and pulsed proton PBS

OC-0928 Comparison of cylindrical and plane-parallel ionization chambers in continuous and pulsed proton PBS

Characterization of a Gd-based color CMOS detector for proton dosimetry

A color scintillation detector for relative dose distribution measurement was developed at PSI. The system consists of a gadolinium-based scintillating screen mounted perpendicularly to the beam axis and coupled with a color CMOS camera in a light-tight box. The camera is equipped with an iris (aperture) controller to remotely adjust the number of photons reaching the image sensor. To improve the measurement accuracy and decrease the image artifacts, we investigated different methods for spatial calibration and optimized the internal light reflection by adjusting the detector structure. The response dependence on camera working distance, iris setting, and color channels was assessed. The depth-dose curves of the gadolinium-based scintillator in three RGB channels were compared with reference curves measured by an Advanced Markus plane-parallel ion chamber. The quenching effect of the ▪ screen measured with this system amounts to about 10% in the Bragg peak region of a 150 MeV proton beams. The shape of the emission spectrum was observed to be independent of the ionization density. Preliminary investigations showed that it is possible to correlate the ratio of the detector response in different color channels with the proton ionization density.

Development and application of absorbed dose primary standard for 60Co and high-energy photon beams using water calorimetry

Several new glass vessels, thermistor probes, and water phantoms have been designed and built at the National Institute of Metrology (China) to upgrade and develop the existing water calorimeter. The increased plane-parallel vessels have shorter thermal stability times and shallower positioning depths (∼1.3 cm) than the previous cylindrical vessels, which makes them suitable for electron beams. The sensitivity of the new probes is 10% greater than the previous ones. In this study, detailed experimental and theoretical investigations of various factors affecting the new water calorimeter are performed. The system uncertainty of the water calorimeter is reduced and the robustness of the determination of the absorbed-dose-to-water D w is improved using a variety of geometric detector vessels and two kinds of high-purity water systems saturated with high-purity gases. This new calorimeter is employed as a primary standard for determining the D w, has achieved a combined standard uncertainty of 0.24% for a 60Co beam, 0.27% for 6 MV and 10 MV photon beams and 0.30% for a 25 MV photon beam. The beam quality conversion factors kQ of ten cylindrical and three plane-parallel ionization chambers are measured using the new calorimeter to improve the reference dosimetry accuracy of high-energy clinical photon beams.

Development of a compact linear accelerator to generate ultrahigh dose rate high-energy X-rays for FLASH radiotherapy applications.

In recent years, the FLASH effect, in which ultrahigh dose rate (UHDR) radiotherapy (RT) can significantly reduce toxicity to normal tissue while maintaining antitumor efficacy, has been verified in many studies and even applied in human clinical cases. This work evaluates whether a room-temperature radio-frequency (RF) linear accelerator (linac) system can produce UHDR high-energy X-rays exceeding a dose rate of 40Gy/s at a clinical source-surface distance (SSD), exploring the possibility of a compact and economical clinical FLASH RT machine suitable for most hospital treatmentrooms. A 1.65m long S-band backward-traveling-wave (BTW) electron linac was developed to generate high-current electron beams, supplied by a commercial klystron-based power source. A tungsten-copper electron-to-photon conversion target for UHDR X-rays was designed and optimized with Monte Carlo (MC) simulations using Geant4 and thermal finite element analysis (FEA) simulations using ANSYS. EBT3 and EBT-XD radiochromic films, which were calibrated with a clinical machine Varian VitalBeam, were used for absolute dose measurements. A PTW ionization chamber detector was used to measure the relative total dose and a plane-parallel ionization chamber detector was used to measure the relative normalized dose of each pulse. The BTW linac generated 300-mA-pulse-current 11 MeV electron beams with 29kW mean beam power, and the conversion target could sustain this high beam power within a maximum irradiation duration of 0.75 s. The mean energy of the produced X-rays was 1.66 MeV in the MC simulation. The measured flat-filter-free (FFF) maximum mean dose rate of the room-temperature linac exceeded 80Gy/s at an SSD of 50cm and 45Gy/s at an SSD of 67.9cm, both at a 2.1cm depth of the water phantom. The FFF radiation fields at 50cm and 67.9cm SSD at a 2.1cm depth of the water phantom showed Gaussian-like distributions with 14.3 and 20cm full-width at half-maximum (FWHM) values, respectively. This work demonstrated the feasibility of UHDR X-rays produced by a room-temperature RF linac, and explored the further optimization of system stability. It shows that a simple and compact UHDR X-ray solution can be facilitated for both FLASH-RT scientific research and clinical applications.

Reduction of recombination effects in large plane parallel beam monitors for FLASH radiotherapy with scanned ion beams

Purpose:Radiotherapy escalating dose rates above 50Gys−1, might offer a great potential in treating tumours while further sparing healthy tissue. However, these ultra-high intensities of FLASH-RT lead to new challenges with regard to dosimetry and beam monitoring. FLASH experiments at HIT (Heidelberg Ion Beam Therapy Center) and at GSI (GSI Helmholtz Centre for Heavy Ion Research) have shown a significant loss of signal in the beam monitoring system due to recombination effects. To enable accurate beam monitoring, this work investigates the recombination loss of different fill gases in the plane parallel ionisation chambers (ICs). Methods:Therefore, saturation curves at high intensities were measured for the currently used fill gases Ar/CO2 (80/20) and pure He and also for He/CO2 mixtures as alternative fill gases. Furthermore, breakdown voltages and ion mobilities were measured in ICs filled with He/CO2 mixtures. A numerical model for volume recombination in plane parallel ionisation chambers was developed and implemented in Python. This includes a novel simulation method of the space charge effect from the charge carriers in the detector volume and predicts a significant effect on the electric field for high intensity beams. Results:Even at high intensities the He/CO2 mixtures allow operation of the ICs at an electric field strength of 2 kVcm−1 or more which reduces recombination to negligible levels at intensities larger than 3 × 101012C-ions per second. Our measurements show that added fractions of CO2 to He decrease the ion mobility in the fill gas but significantly increase the breakdown voltage in the ICs compared to pure He.

Position sensitive detectors in proton therapy: online monitoring of the beam position

Spot-scanning is a highly dynamic treatment method in proton therapy, tailored to each tumor shape individually. By superimposing many single spots in all three spatial axes, a prescribed dose is applied to the tumor volume. To minimize dose inhomogeneity across this volume, tight constraints on the beam position accuracy apply: for a dose inhomogeneity below 1%, a longitudinal beam position accuracy of the order of 1 mm is necessary, whereas in the lateral plane, the accuracy needs to be roughly one order of magnitude better. Longitudinal position control is achieved through selecting the beam energy; laterally, this is achieved by two sweeper magnets, allowing position changes within milliseconds. Such dynamics and accuracy constraints require an online measurement of the beam position to enable and maintain high treatment quality assurance. Gantry 2 at the Center for Proton Therapy at PSI operates a plane parallel strip ionization chamber for this purpose as the final beamline element before the patient. The foil-based detector design is optimized for an in-situ placement in the beam axis and keeps beam disturbance at a minimum. A strip pitch of 2 mm allows to reconstruct the Gaussian shape beam profile with the desired accuracy. These beam profiles are analyzed (and verified) during a treatment on a spot-by-spot basis, before the next spot is applied, introducing a dead time after every spot. Applying 50, 000 spots in a treatment introduces the challenge to data acquisition and — processing in terms of keeping treatment times reasonable. Data pileup and long dead times are mitigated by optimized front-end electronics and early-stage data processing, without compromising data quality and the accuracy of the measured beam position.

Ultrahigh dose rate pencil beam scanning proton dosimetry using ion chambers and a calorimeter in support of first in-human FLASH clinical trial.

PurposeTo provide ultrahigh dose rate (UHDR) pencil beam scanning (PBS) proton dosimetry comparison of clinically used plane‐parallel ion chambers, PTW (Physikalisch‐Technische Werkstaetten) Advanced Markus and IBA (Ion Beam Application) PPC05, with a proton graphite calorimeter in a support of first in‐human proton FLASH clinical trial.MethodsAbsolute dose measurement intercomparison of the plane‐parallel plate ion chambers and the proton graphite calorimeter was performed at 5‐cm water‐equivalent depth using rectangular 250‐MeV single‐layer treatment plans designed for the first in‐human FLASH clinical trial. The dose rate for each field was designed to remain above 60 Gy/s. The ion recombination effects of the plane‐parallel plate ion chambers at various bias voltages were also investigated in the range of dose rates between 5 and 60 Gy/s. Two independent model‐based extrapolation methods were used to calculate the ion recombination correction factors ks to compare with the two‐voltage technique from most widely used clinical protocols.ResultsThe mean measured dose to water with the proton graphite calorimeter across all the predefined fields is 7.702 ± 0.037 Gy. The average ratio over the predefined fields of the PTW Advanced Markus chamber dose to the calorimeter reference dose is 1.002 ± 0.007, whereas the IBA PPC05 chamber shows ∼3% higher reading of 1.033 ± 0.007. The relative differences in the ks values determined from between the linear and quadratic extrapolation methods and the two‐voltage technique for the PTW Advanced Markus chamber are not statistically significant, and the trends of dose rate dependence are similar. The IBA PPC05 shows a flat response in terms of ion recombination effects based on the ks values calculated using the two‐voltage technique. Differences in ks values for the PPC05 between the two‐voltage technique and other model‐based extrapolation methods are not statistically significant at FLASH dose rates. Some of the ks values for the PPC05 that were extrapolated from the three‐voltage linear method and the semiempirical model were reported less than unity possibly due to the charge multiplication effect, which was negligible compared to the volume recombination effect in FLASH dose rates.ConclusionsThe absolute dose measurements of both PTW Advanced Markus and IBA PPC05 chambers are in a good agreement with the National Physical Laboratory graphite calorimeter reference dose considering overall uncertainties. Both ion chambers also demonstrate good reproducibility as well as stability as reference dosimeters in UHDR PBS proton radiotherapy. The dose rate dependency of the ion recombination effects of both ion chambers in cyclotron generated PBS proton beams is acceptable and therefore, both chambers are suitable to use in clinical practice for the range of dose rates between 5 and 60 Gy/s.

Determination of Integral Depth Dose in Proton Pencil Beam Using Plane-parallel Ionization Chambers.

PurposeThis study aimed to determine the integral depth-dose curves and assess the geometric collection efficiency of different detector diameters in proton pencil beam scanning.Materials and MethodsThe Varian ProBeam Compact spot scanning system was used for this study. The integral depth-dose curves with a proton energy range of 130 to 220 MeV were acquired with 2 types of Bragg peak chambers: 34070 with 8-cm diameter and 34089 with 15-cm diameter (PTW), multi-layer ionization chamber with 12-cm diameter (Giraffe, IBA Dosimetry), and PeakFinder with 8-cm diameter (PTW). To assess geometric collection efficiency, the integral depth-dose curves of 8- and 12-cm chamber diameters were compared to a 15-cm chamber diameter as the largest detector.ResultsAt intermediate depths of 130, 150, 190, and 220 MeV, PTW Bragg peak chamber type 34089 provided the highest integral depth-dose curves followed by IBA Giraffe, PTW Bragg peak chamber type 34070, and PTW PeakFinder. Moreover, PTW Bragg peak chamber type 34089 had increased geometric collection efficiency up to 3.8%, 6.1%, and 3.1% when compared to PTW Bragg peak chamber type 34070, PTW PeakFinder, and IBA Giraffe, respectively.ConclusionA larger plane-parallel ionization chamber could increase the geometric collection efficiency of the detector, especially at intermediate depths and high-energy proton beams.

Dose area product primary standards established by graphite calorimetry at the LNE-LNHB for small radiation fields in radiotherapy

PurposeTo present primary standards establishment in terms of Dose Area Product (DAP) for small field sizes. MethodsA large section graphite calorimeter and two plane-parallel ionization chambers were designed and built in-house. These chambers were calibrated in a 6MV FFF beam at the maximum dose rate of 1400 UM/min for fields defined by specifically designed circular collimators of 5, 7.5, 10, 13 and 15 mm diameter and jaws of 5, 7, 10, 13 and 15 mm side length on a Varian TrueBeam linac. ResultsThe two chambers show the same behaviour regardless of field shape and size. From 5 to 15 mm, calibration coefficients slightly increase with the field size with a magnitude of 1.8% and 1.1% respectively for the two chambers, and are independent of the field shape. This tendency was confirmed by Monte Carlo calculations. The average associated uncertainty of the calibration coefficients is around 0.6% at k=1. ConclusionsFor the first time, primary standards in terms of DAP were established by graphite calorimetry for an extended range of small field sizes. These promising results open the door for an alternative approach in small fields dosimetry.

Analysis of Uncertainties in Clinical High-Energy Photon Beam Calibrations Using Absorbed Dose Standards

We compared the results of absorbed dose measurements made using the TRS-398, TG-51, and DIN protocols and their associated uncertainties to reduce discrepancies in measurement results made using the three protocols. This experiment was carried out on two Varian Medical linear accelerators with 4, 6, 10, and 20 MV photon energies using FC65-G and CC15 (cylindrical) and NACP-02-type (plane-parallel) ion chambers in water phantoms. The radiation beam quality index (Q) was determined from the measurement of percentage depth dose. It was used to determine the photon beam quality factor required with the ionization chamber calibration factor to convert the ion chamber reading into the absorbed dose to water. For the same beam quality, the TRS-398/TG-51 varied from 0.01% to 1.8%, whereas the ratio for TRS-398/DIN 6800-2 varied from 0.1% to 0.88%. The chamber-to-chamber variation was 0.09% in TRS-398/TG-51, 0.03% in TRS-398/DIN, and 0.02% in TG-51/DIN 6800-2. The expanded uncertainties (k = 1) were 1.24 and 1.25 when using TRS-398 and DIN 6800-2, respectively. Using the aforementioned three protocols, the results showed little chamber-to-chamber variation and uncertainty in absorbed dose measurements. The estimated uncertainties when using cylindrical ion chambers were slightly lower than those measured using plane-parallel chambers. The results are important in facilitating comparisons of absorbed dose measurements when using the three protocols.

Determination of beam quality correction factors for the Roos plane-parallel ionisation chamber exposed to very high energy electron (VHEE) beams using Geant4

Detailed characterisation of the Roos secondary standard plane-parallel ionisation chamber has been conducted in a novel 200 MeV Very High Energy Electron (VHEE) beam with reference to the standard 12 MeV electron calibration beam used in our experimental work. Stopping-power-ratios and perturbation factors have been determined for both beams and used to calculated the beam quality correction factor using the Geant4 general purpose MC code. These factors have been calculated for a variety of charged particle transport parameters available in Geant4 which were found to pass the Fano cavity test. Stopping-power-ratios for the 12 MeV electron calibration beam quality were found to agree within uncertainties to that quoted by current dosimetry protocols. Perturbation factors were found to vary by up-to 4% for the calibration beam depending on the parameter configuration, compared with only 0.8% for the VHEE beam. Beam quality correction factors were found to describe an approximately 10% lower dose than would be originally calculated if a beam quality correction were not accounted for. Moreover, results presented here largely resolve unphysical chamber measurements, such as collection efficiencies greater than 100%, and assist in the accurate determination of absorbed dose and ion recombination in secondary standard ionisation chambers.

Comparison of Dosimetry Protocols for Electron Beam Radiotherapy Calibrations and Measurement Uncertainties.

This paper presents guidelines for the calibration of radiation beams that were issued by the International Atomic Energy Agency (IAEA TRS 398), the American Association of Physicists in Medicine (AAPM TG 51) and the German task group (DIN 6800-2). These protocols are based on the use of an ionization chamber calibrated in terms of absorbed dose to water in a standard laboratory’s reference quality beam, where the previous protocols were based on air kerma standards. This study aims to determine uncertainties in dosimetry for electron beam radiotherapy using internationally established high-energy radiotherapy beam calibration standards. Methods: Dw was determined in 6-, 12- and 18 MeV electron energies under reference conditions using three cylindrical and two plane-parallel ion chambers in concert with the IAEA TRS 398, AAPM TG 51 and DIN 6800-2 absorbed dose protocols. From mean measured Dw values, the ratio TRS 398/TG 51 was found to vary between 0.988 and 1.004, while for the counterpart TRS 398/DIN 6800-2 and TG 51/DIN 6800-2, the variation ranges were 0.991–1.003 and 0.997–1.005, respectively. For the cylindrical chambers, the relative combined uncertainty (k = 1) in absorbed dose measurements was 1.44%, while for the plane-parallel chambers, it ranged from 1.53 to 1.88%. Conclusions: A high degree of consistency was demonstrated among the three protocols. It is suggested that in the use of the presently determined dose conversion factors across the three protocols, dose intercomparisons can be facilitated between radiotherapy centres.

Technical note: Experimental determination of the effective point of measurement of the PTW-31010 ionization chamber in proton and carbon ion beams.

The accurate knowledge of the effective point of measurement (Peff ) is particularly important for measurements in proximity to high dose gradients such as in the distal fall-off of particle beams. For plane-parallel ionization chambers (ICs), Peff is well known and located at the center of the inner surface of the entrance window. For cylindrical ICs, Peff is shifted from the chamber's center toward the beam source. According to IAEA TRS-398, this shift can be calculated as 0.75·rcyl for light ions with rcyl being the radius of the cavity. For proton beams and in absence of a dose gradient, no shift is recommended. We have experimentally determined Peff for the 0.125cc Semiflex IC in both proton and carbon ion beams. The first method consisted of simultaneous irradiation of a plane-parallel IC and the Semiflex in a 4-cm wide spread-out Bragg peak. In the second method, a single-energy beam was used, and both ICs were positioned successively at the same measurement depths. For both approaches, the shift of the distal edge of the depth ionization distributions recorded by the two chambers at different reference points was used to calculate Peff of the Semiflex. Both methods were applied in carbon ion beams, and only the latter was applied in proton beams. Both methods yielded a similar Peff for carbon ions, 0.88·rcyl , and 0.84·rcyl , which results in a difference of only 0.1mm. The difference to the recommended value of 0.75·rcyl is 0.4 and 0.3mm, respectively, which is larger than the positioning uncertainty. In the proton beam, a Peff of 0.92·rcyl was obtained. The Peff for the 0.125ccSemiflex IC is shifted further from the cavity center as recommended by IAEA TRS-398 for light ions, with the shift for proton beams being even larger than for carbon ion beams.

Electron Beam Measurements Employing Electron Montecarlo Algorithm on TrueBeam STx® and Clinac iX® Linear Accelerators

Electron beam measurement comparison between TrueBeam STx® and Clinac iX® established. Data evaluation of eMC-calculated and measured for TrueBeam STx® performed. Dosimetric parameters measured including depth dose curves for each applicator, percentage depth dose (PDDs) curves without applicator, the profile in-air for a large field size 40×40 cm2, and the Absolute Dose (cGy/MU) for each applicator using a large water phantom (PTW, Freiburg, Germany), employing Roos and Markus plane-parallel ionization chambers. The data were examined for five electron beams of Varian’s TrueBeam STx® and Clinac iX® machines. A comparison between measurement PDDs and calculated by the Eclipse electron Monte Carlo (eMC) algorithm was performed to validate Truebeam STx® commissioning. The measured data indicated that electron beam PDDs from the TrueBeam STx® machine are well matched to those from Clinac iX® machine. The quality index R50 for applicator 15×15 cm2 was in the tolerance intervals. However, Surface dose (Ds) increases with increasing energy for both accelerators. Comparisons between the measured and eMC-calculated values revealed that the R100, R90, R80, and R50 values mostly agree within 5 mm. Measured and calculated bremsstrahlung tail Rp correlates well statistically. Ds agrees mostly within 2%. Electron beams were successfully validated for TrueBeam STx®, a good agreement between modeled and measured data was observed.

Dosimetric accuracy of a cross-calibration coefficient for plane-parallel ionization chamber obtained in low-energy electron beams using various cylindrical dosimeters

Abstract Introduction: The accuracy of the cross-calibration procedure depends on ionization chamber type, both used as reference one and under consideration. Also, the beam energy and phantom medium could influence the precision of cross calibration coefficient, resulting in a systematic error in dose estimation and thus could influence the linac beam output checking. This will result in a systematic mismatch between dose calculated in treatment planning system and delivered to the patient. Material and methods: The usage of FC65-G, CC13 and CC01 thimble reference chambers as well as 6, 9, and 15 MeV electron beams has been analyzed. A plane-parallel PPC05 chamber was calibrated since scarce literature data are available for this dosimeter type. The influence of measurement medium and an effective point of measurement (EPOM) on obtained results are also presented. Results: Dose reconstruction precision of ~0.1% for PPC05 chamber could be obtained when cross-calibration is based on a thimble CC13 chamber. Nd,w,Qcross obtained in beam ≥ 9MeV gives 0.1 – 0.5% precision of dose reconstruction. Without beam quality correction, 15 MeV Nd,w,Qcross is 10% lower than Co-60 Nd,w,0. Various EPOM shifts resulted in up to 0.6% discrepancies in Nd,w,Qcross values. Conclusions: Ionization chamber with small active volume and tissue-equivalent materials supplies more accurate cross-calibration coefficients in the range of 6 – 15 MeV electron beams. In the case of 6 and 9 MeV beams, the exact position of an effective point of measurement is of minor importance. In-water cross-calibration coefficient can be used in a solid medium without loss of dose accuracy.

Dosimetric Impact of Dose Rate Fall-Off in FLASH Proton Pencil Beam Scanning Treatment

Dosimetric Impact of Dose Rate Fall-Off in FLASH Proton Pencil Beam Scanning Treatment