Several papers have recorded the stimulation by 1,2,5,6-dibenzanthracene of the growth of a variety of organisms, such as Obelia (1), Escherichia communior (2), planaria (3), and Fusarium lini (4). The hydrocarbon has also been found to depress the respiration of brain, spleen, and liver (5). In view of the fact that cancer tissue is generally characterized by rapid growth and deficient respiration, these findings are significant, and it is surprising that so few attempts have been made to correlate the two types of action on simple organisms. In an earlier note (6) we called attention to the effect of 1,2,5,6-dibenzanthracene on the growth and respiration of yeast, and subsequently Wright and Anderson (4) showed that a soluble oxidation product of the hydrocarbon not only stimulates the growth of Fusarium lini , as indicated by dry weight determinations, but also causes a more rapid utilization of glucose. Pourbaix (7) observed that another carcinogenic agent, styryl 430, depresses the oxygen consumption of yeast and decreases alcohol formation by interfering with the phosphorylation mechanism.