Planar Imaging Research Articles

DMD-based spatiotemporal superresolution measurement of a supersonic jet using dual planar PIV and acoustic data

The present study applies a framework of the spatiotemporal superresolution measurement based on the total-least-squares dynamic mode decomposition, the Kalman filter and the Rauch-Tung-Striebel smoother to an axisymmetric underexpanded supersonic jet of a jet Mach number of 1.35. Dual planar particle image velocimetry was utilized, and paired velocity fields of the flow with a short time interval were obtained at a temporal resolution of 5000 Hz. High-frequency acoustic data of 200,000 Hz were simultaneously obtained. Then, the time-resolved velocity fields of the supersonic jet were reconstructed at a temporal resolution of 200,000 Hz. Also, time coefficients of dynamic modes in high temporal resolution were calculated. The correlation between time coefficients implies that the mixing promotion by screech tone causes the lift-up of the high-velocity fluid from the jet center and accelerates at the downstream side.

Recognition of the lumbar spine using MRI plane-based FiLM conditioning and patient dependent batching on semantic segmentation

Abstract Lower back pain (LBP) is a common symptom that can be linked to the degeneration of intervertebral discs or injuries to vertebrae. Accurate segmentation of lumbar spinal structures is vital for image-based surgery planning but can be resource intensive. Recent studies have shown that U-Net models can be used reliably to segment vertebrae and intervertebral discs from medical imaging data. This study investigated the potential of combining multiple planar MRI images to segment these structures automatically. The study used MRI data from 83 patients with back pain of the lower spine, with ground truth segmentations performed by a spine surgery specialist using Mimics software. The segmentation models were trained using a specialized patient batching method and a FiLMed U-Net model, which applies a Feature-wise Linear Modulation layer to improve mask generation. The models were trained using a 10-fold cross validation study, and the dice loss was used as the objective function. The study found that both patient batching and FiLM layers improve results by around 5% compared to a baseline U-Net. The average IoU scores of the patient batching method were 0.896 for vertebrae and 0.876 intervertebral disc segmentation. The FiLMed U-Net model achieved average IoU scores of 0.844 and 0.814 and against a baseline of 0.837 and 0.774, respectively. A web-based tool was developed to enable medical personnel to assess segmentation quality visually. Overall, the study indicates that U-Nets show better segmentation potential when using imaging data with complete 3D information of one patient. Future studies should focus on increasing the dataset size and exploring other 3D model architectures to improve segmentation performance.

High‐resolution incoherent interference imaging without phase measurement

AbstractAiming for long‐distance, high‐resolution, passive imaging, we use fiber coupling to replace the spatial coupling of the segmented planar imaging detector for electro‐optical reconnaissance imaging system and propose a novel incoherent interference imaging method, which avoids the problem that the resolution of the imaging system is limited by the size of the silicon wafer. The method uses a phase retrieval algorithm and does not need to measure the phase in the system, effectively avoiding the intrinsic jitter problem of fiber optics. The feasibility of the method in achieving target image reconstruction was verified through simulation; furthermore, an indoor two‐dimensional discrete sampling imaging experiment for a simple four‐rod target was conducted, and an outdoor one‐dimensional feature identification experiment for a two‐rod target was also performed. The results showed that the resolution exceeds the diffraction limit and the reconstruction error of target size is less than 3.5%.

Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early-Stage Parkinson's Disease: A Systematic Review and Meta-Analysis.

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early detection is crucial for treatment and slowing disease progression. Simultaneous alterations in mean susceptibility (MS) from quantitative susceptibility mapping (QSM) and mean kurtosis (MK) from diffusion kurtosis imaging (DKI) can serve as reliable neuroimaging biomarkers for early-stage PD (ESPD) in the basal ganglia nuclei, including the substantia nigra (SN), putamen (PUT), globus pallidus (GP), and caudate nucleus (CN). Systematic review and meta-analysis. One hundred eleven patients diagnosed with ESPD and 81 healthy controls (HCs) were included from four studies that utilized both QSM and DKI in both subject groups. Three-dimensional multi-echo gradient echo sequence for QSM and spin echo planar imaging sequence for DKI at 3 Tesla. A systematic review and meta-analysis using PRISMA guidelines searched PubMed, Web of Science, and Scopus. Random-effects model, standardized mean difference (SMD) to compare MS and MK between ESPD patients and HCs, I2 statistic for heterogeneity, Newcastle-Ottawa Scale (NOS) for risk of bias, and Egger's test for publication bias. A P-value <0.05 was considered significant. MS values were significantly higher in SN (SMD 0.72, 95% CI 0.31 to 1.12), PUT (SMD 0.68, 95% CI 0.29 to 1.07), and GP (SMD 0.53, 95% CI 0.19 to 0.87) in ESPD patients compared to HCs. CN did not show a significant difference in MS values (P = 0.15). MK values were significantly higher only in SN (SMD = 0.72, 95% CI 0.16 to 1.27). MK values were not significantly different in PUT (P = 1.00), GP (P = 0.97), and CN (P = 0.59). Studies had high quality (NOS 7-8) and no publication bias (P = 0.967). Simultaneous use of MS and MK may be useful as an early neuroimaging biomarker for ESPD detection and its differentiation from HCs, with significant differences observed in the SN. 2 TECHNICAL EFFICACY: Stage 2.

How anatomical impairments found on CT affect perfusion percentage assessed by SPECT/CT scan?

CT images can identify structural and opacity alterations of the lungs while nuclear medicine's lung perfusion studies show the homogeneity (or lack of) of blood perfusion on the organ. Therefore, the use of SPECT/CT in lung perfusion scintigraphies can help physicians to assess anatomical and functional alterations of the lungs and to differentiate between acute and chronic disease. To develop a computer-aided methodology to quantify the total global perfusion of the lungs via SPECT/CT images and to compare these results with parenchymal alterations obtained in CT images. 39 perfusion SPECT/CT images collected retrospectively from the Nuclear Medicine Facility of Botucatu Medical School's Clinics Hospital in São Paulo, Brazil, were analyzed. Anatomical lung impairments (emphysema, collapsed and infiltrated tissue) and the functional percentage of the lungs (blood perfusion) were quantified from CT and SPECT images, with the aid of the free, open-source software 3D Slicer. The results obtained with 3D Slicer (3D-TGP) were also compared to the total global perfusion of each patient's found on their medical report, obtained from visual inspection of planar images (2D-TGP). This research developed a novel and practical methodology for obtaining lungs' total global perfusion from SPECT/CT images in a semiautomatic manner. 3D-TGP versus 2D-TGP showed a bias of 7% with a variation up to 67% between the two methods. Perfusion percentage showed a weak positive correlation with infiltration (p = 0.0070 and ρ = 0.43) and collapsed parenchyma (p = 0.040 and ρ = 0.33). This research brings meaningful contributions to the scientific community because it used a free open-source software to quantify the lungs blood perfusion via SPECT/CT images and pointed that the relationship between parenchyma alterations and the organ's perfusion capability might not be so direct, given compensatory mechanisms.

Assessment of Tumor Cell Invasion and Radiotherapy Response in Experimental Glioma by Magnetic Resonance Elastography.

Gliomas are highly invasive brain neoplasms. MRI is the most important tool to diagnose and monitor glioma but has shortcomings. In particular, the assessment of tumor cell invasion is insufficient. This is a clinical dilemma, as recurrence can arise from MRI-occult glioma cell invasion. Tumor cell invasion, tumor growth and radiotherapy alter the brain parenchymal microstructure and thus are assessable by diffusion tensor imaging (DTI) and MR elastography (MRE). Experimental, animal model. Twenty-three male NMRI nude mice orthotopically implanted with S24 patient-derived glioma cells (experimental mice) and 9 NMRI nude mice stereotactically injected with 1 μL PBS (sham-injected mice). 2D and 3D T2-weighted rapid acquisition with refocused echoes (RARE), 2D echo planar imaging (EPI) DTI, 2D multi-slice multi-echo (MSME) T2 relaxometry, 3D MSME MRE at 900 Hz acquired at 9.4 T (675 mT/m gradient strength). Longitudinal 4-weekly imaging was performed for up to 4 months. Tumor volume was assessed in experimental mice (n = 10 treatment-control, n = 13 radiotherapy). The radiotherapy subgroup and 5 sham-injected mice underwent irradiation (3 × 6 Gy) 9 weeks post-implantation/sham injection. MRI-/MRE-parameters were assessed in the corpus callosum and tumor core/injection tract. Imaging data were correlated to light sheet microscopy (LSM) and histology. Paired and unpaired t-tests, a P-value ≤0.05 was considered significant. From week 4 to 8, a significant callosal stiffening (4.44 ± 0.22 vs. 5.31 ± 0.29 kPa) was detected correlating with LSM-proven tumor cell invasion. This was occult to all other imaging metrics. Histologically proven tissue destruction in the tumor core led to an increased T2 relaxation time (41.65 ± 0.34 vs. 44.83 ± 0.66 msec) and ADC (610.2 ± 12.27 vs. 711.2 ± 13.42 × 10-6 mm2/s) and a softening (5.51 ± 0.30 vs. 4.24 ± 0.29 kPa) from week 8 to 12. Radiotherapy slowed tumor progression. MRE is promising for the assessment of key glioma characteristics. NA TECHNICAL EFFICACY: Stage 2.

Reliability of task-based fMRI in the dorsal horn of the human spinal cord

Abstract The application of functional magnetic resonance imaging (fMRI) to the human spinal cord is still a relatively small field of research and faces many challenges. Here we aimed to probe the limitations of task-based spinal fMRI at 3T by investigating the reliability of spinal cord blood oxygen level dependent (BOLD) responses to repeated nociceptive stimulation across 2 consecutive days in 40 healthy volunteers. We assessed the test–retest reliability of subjective ratings, autonomic responses, and spinal cord BOLD responses to short heat-pain stimuli (1 s duration) using the intraclass correlation coefficient (ICC). At the group level, we observed robust autonomic responses as well as spatially specific spinal cord BOLD responses at the expected location, but no spatial overlap in BOLD response patterns across days. While autonomic indicators of pain processing showed good-to-excellent reliability, both β-estimates and z-scores of task-related BOLD responses showed poor reliability across days in the target region (gray matter of the ipsilateral dorsal horn). When taking into account the sensitivity of gradient-echo echo planar imaging (GE-EPI) to draining vein signals by including the venous plexus in the analysis, we observed BOLD responses with fair reliability across days. Taken together, these results demonstrate that heat-pain stimuli as short as 1 s are able to evoke a robust and spatially specific BOLD response, which is, however, strongly variable within participants across time, resulting in low reliability in the dorsal horn gray matter. Further improvements in data acquisition and analysis techniques are thus necessary before event-related spinal cord fMRI as used here can be reliably employed in longitudinal designs or clinical settings.

Droplet size, spray structure and droplet velocity mapping in hollow cone sprays using SLIPI-based techniques

The Structured Laser Illumination Planar Imaging (SLIPI) technique received significant attention in recent years due to notable improvements in the measurement of droplet size and the visualization of internal structure in both dilute and dense sprays. However, despite the improvements, the technique remains limited to these microscopic characteristics of the spray, primarily due to the complexity of the optical setup and image acquisition process. In this article, the capabilities of the SLIPI application are exploited, specifically employing the 3p-SLIPI-LIF/Mie (SLSD), and combined application of 1p-SLIPI-LIF & PIV (1p-SLIPI-PIV) for mapping of both Sauter Mean Diameter (SMD) and mean droplet velocity in combination with detailed spray structure analysis. The measurements were carried out in hollow cone sprays operated at the range of injection pressures from 25 to 107 bar. The results obtained using the SLIPI techniques were compared with the Phase Doppler Anemometry (PDA) measurements showing good agreement for both the SMD and mean droplet velocity. The significant improvements in the important microscopic characteristics (droplet size & velocity) and visualization of the internal structure in a wider flow field of hollow cone sprays allowed detailed analysis and understanding of the dispersed phase flow owing to the suppression of diffused light resulting from the multiple scattering effects.

Multiparametric MRI-Based Deep Learning Radiomics Model for Assessing 5-Year Recurrence Risk in Non-Muscle Invasive Bladder Cancer.

Accurately assessing 5-year recurrence rates is crucial for managing non-muscle-invasive bladder carcinoma (NMIBC). However, the European Organization for Research and Treatment of Cancer (EORTC) model exhibits poor performance. To investigate whether integrating multiparametric MRI (mp-MRI) with clinical factors improves NMIBC 5-year recurrence risk assessment. Retrospective. One hundred ninety-one patients (median age, 65 years; age range, 54-73 years; 27 females) underwent mp-MRI between 2011 and 2017, and received ≥5-year follow-ups. They were divided into a training cohort (N = 115) and validation/testing cohorts (N = 38 in each). Recurrence rates were 23.5% (27/115) in the training cohort and 23.7% (9/38) in both validation and testing cohorts. 3-T, fast spin echo T2-weighted imaging (T2WI), single-shot echo planar diffusion-weighted imaging (DWI), and volumetric spoiled gradient echo dynamic contrast-enhanced (DCE) sequences. Radiomics and deep learning (DL) features were extracted from the combined region of interest (cROI) including intratumoral and peritumoral areas on mp-MRI. Four models were developed, including clinical, cROI-based radiomics, DL, and clinical-radiomics-DL (CRDL) models. Student's t-tests, DeLong's tests with Bonferroni correction, receiver operating characteristics with the area under the curves (AUCs), Cox proportional hazard analyses, Kaplan-Meier plots, SHapley Additive ExPlanations (SHAP) values, and Akaike information criterion for clinical usefulness. A P-value <0.05 was considered statistically significant. The cROI-based CRDL model showed superior performance (AUC 0.909; 95% CI: 0.792-0.985) compared to other models in the testing cohort for assessing 5-year recurrence in NMIBC. It achieved the highest Harrell's concordance index (0.804; 95% CI: 0.749-0.859) for estimating recurrence-free survival. SHAP analysis further highlighted the substantial role (22%) of the radiomics features in NMIBC recurrence assessment. Integrating cROI-based radiomics and DL features from preoperative mp-MRI with clinical factors could improve 5-year recurrence risk assessment in NMIBC. 3 TECHNICAL EFFICACY: Stage 3.

Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [99mTc]Tc(CO)3-(HE)3-Ec1 for Visualization of EpCAM-Expressing Lung Cancer.

A high level of EpCAM overexpression in lung cancer makes this protein a promising target for targeted therapy. Radionuclide visualization of EpCAM expression would facilitate the selection of patients potentially benefiting from such treatment. Single-photon computed tomography (SPECT) using 99mTc-labeled engineered scaffold protein DARPin Ec1 has shown its effectiveness in imaging tumors with overexpression of EpCAM in preclinical studies, providing high contrast just a few hours after injection. This first-in-human study aimed to evaluate the safety and distribution of [99mTc]Tc(CO)3-(HE)3-Ec1 in patients with primary lung cancer. Twelve lung cancer patients were injected with 300.7 ± 103.2 MBq of [99mTc]Tc(CO)3-(HE)3-Ec1. Whole-body planar imaging (at 2, 4, 6 and 24 h after injection) and SPECT/CT of the lung (at 2, 4, and 6 h) were performed. The patients' vital signs and possible side effects were monitored up to 7 days after injection. The patients tolerated the injection of [99mTc]Tc(CO)3-(HE)3-Ec1 well, and their somatic condition remained normal during the entire follow-up period. There were no abnormalities in blood and urine tests after injection of [99mTc]Tc(CO)3-(HE)3-Ec1. The highest absorbed doses were in the kidneys, liver, pancreas, thyroid, gallbladder wall, and adrenals. There was also a relatively high accumulation of [99mTc]Tc(CO)3-(HE)3-Ec1 in the small and large intestines, pancreas and thyroid. According to the SPECT/CT, accumulation of [99mTc]Tc(CO)3-(HE)3-Ec1 in the lung tumor was found in all patients included in the study. Intensive accumulation of [99mTc]Tc(CO)3-(HE)3-Ec1 was also noted in regional metastases. [99mTc]Tc(CO)3-(HE)3-Ec1 can potentially be considered a diagnostic tracer for imaging EpCAM expression in lung cancer patients and other tumors with overexpression of EpCAM.

99mTc]Tc-hydroxydiphosphonate uptake in soft tissue is associated with amyloid load in subcutaneous abdominal fat tissue and mortality in wild-type transthyretin amyloidosis patients.

Bone scintigraphy is key to non-invasively diagnosing wild-type transthyretin (ATTRwt) amyloidosis, and is mainly used to assess cardiac radiotracer uptake. However, extracardiac radiotracer uptake is also observed. We investigated whether intensity of soft tissue radiotracer uptake is associated with amyloid load in subcutaneous abdominal fat tissue and with mortality. This prospective cohort study included 94 ATTRwt amyloidosis patients and 26 amyloid-negative heart failure controls who underwent whole-body [99mTc]Tc-hydroxydiphosphonate scintigraphy. Site-to-background ratios were calculated for heart, elbows, subcutaneous tissue, shoulders and wrists on anterior planar bone scintigraphy images using rib and whole-body radiotracer uptake as background. Fat tissue aspirates were stained with Congo red to grade amyloid load. Site-to-rib ratios were compared between ATTRwt amyloidosis patients and controls, and associations of site-to-background ratio with Congo red score and all-cause mortality were studied. ATTRwt amyloidosis patients had higher soft tissue-to-rib, heart-to-rib and heart-to-whole body ratios compared with controls. The intensity of soft tissue uptake was positively associated with amyloid load in fat tissue in ATTRwt amyloidosis patients. Estimated glomerular filtration rate, N-terminal brain natriuretic propeptide, high-sensitivity cardiac troponin T (hs-cTnT), and the prognostic Mayo and NAC staging system were associated with all-cause mortality in univariable models. Soft tissue/rib ratio, hs-cTnT and the prognostic staging systems were the only two variables that were independently associated withall-cause mortality. Soft tissue radiotracer uptake on bone scintigraphy in ATTRwt amyloidosis patients is positively associated with amyloid load in abdominal fat tissue and is independently associated with mortality.

Experimental evaluation of the flow field induced by an active vortex generator

This investigation examined the flow field generated by a ramp-shaped vortex generator (VG) that underwent active oscillation within a laminar boundary layer. The oscillations were applied through a servomotor, which pivoted the VG around its leading edge. The study evaluated the influence of varying the maximum VG height during the oscillations (h), actuation frequency (f), and the waveform governing the periodic oscillation of the VG. Planar particle image velocimetry (PIV) measurements were conducted to estimate flow mixing and the drag induced by the VG. The height-based Reynolds number (Reh) ranged from 300 to 600, and the chord-based Strouhal number (Stc) for the oscillations varied from 0.67 to 3.33. The findings of the study indicate that active VGs lead to a greater wall-normal transport of streamwise momentum and result in lower drag compared to static VGs. Furthermore, increasing h results in larger momentum transport and drag of the active VGs. The investigation also revealed that the highest momentum transport and drag occurred when f was close to the instability frequency of the shear layer. The results show the potential of active VGs for separation control under various flow conditions.

Three-Dimensional Nature of Low-Frequency Unsteadiness in a Turbulent Separation Bubble

Three-dimensional behavior of low-frequency unsteadiness in the incompressible turbulent separation bubble (TSB) produced by a wall-mounted hump is investigated using time-resolved planar and stereoscopic particle image velocimetry measurements at several planes across the separated region. The aspect ratio (wind tunnel width/separation length, Lz,WT/Lb=4.4) provides nominally two-dimensional flow for more than half of the spanwise extent of the test section. Analysis in the streamwise/wall-normal plane along the center of the test section shows low-frequency (St<0.1) large-scale motion of the separated region. The flowfield contains features of both geometry-induced and pressure-gradient-induced separation, but unsteady dynamics produce dominant frequencies closer to geometry-induced TSBs (St≈0.1) compared to purely pressure-gradient-induced TSBs (St≈0.01). Measurements along the spanwise direction and parallel to the initial shear layer development show strong evidence that the low-frequency motion is inherently three-dimensional, providing an additional dimension to the understanding of the flapping/breathing typically observed in planar streamwise/wall-normal measurements. Spectral proper orthogonal decomposition and low-order modeling identify spanwise undulations with wavelengths of the order of Lb and frequencies of St<0.1. The three-dimensional behavior causes a peak/valley formation along the span and a more localized expansion/contraction, leading to only small variations in the integral volume of the TSB.

Tracing N2O from dairy processing sludge amended soil with visualizing microscale heterogeneity of NH3 and pH (Short Communication)

Nitrous oxide (N2O) emissions from organic waste and animal slurry contribute to climate change and endanger our ecosystems. For the development of efficient mitigation technologies, in-depth knowledge of emission processes is needed. This can be obtained by non-destructive, temporal measurements of in-situ soil profiles and the transformation of ammonium (NH4+) during events of emissions. Planar optode imaging is a non-destructive measuring method that can be used to visualize spatiotemporal changes of ammonia (NH3) and pH in soil systems. In this study, soil amended with dairy processing sludge (DPS) was incubated in static chambers for 23 days, and GHG emissions, NH3 concentrations and pH in the soil were measured simultaneously over time. The aim was to investigate the potential of applying different planar optodes to provide information that gives insight into processes of N2O emissions. The DPS was applied to the soil as a surface layer (SL), with untreated soil as a control (CK). We were able to measure N2O emissions while monitoring spatiotemporal changes of soil pH and NH3 concentrations. The visualized microscale heterogeneity of the soil contributed to a better understanding of N2O emission processes. While technical challenges (e.g., humidity sensitivity of the NH3 optode and airtightness of the chambers) still need to be overcome, the method is a promising non-destructive method to study soil processes after application of different types of soil amendments.

Effects of oral contrast agent on the viscoelastic properties of the terminal ileum investigated using magnetic resonance elastography.

While standard clinical magnetic resonance (MR) enterography can detect inflammatory bowel disease, it is of limited value in deciding between medical versus surgical treatment. Alternatively, intestinal MR elastography has the potential to contribute additional information to therapeutic decision-making; however, the influence of bowel distension by oral contrast agent on viscoelastic tissue properties remains elusive. Therefore, we aimed to investigate the influence of oral contrast agent-induced bowel distension on the viscoelastic properties of the terminal ileum in healthy volunteers. In this prospective pilot study, 20 healthy volunteers (33.2±8.2 years; 10 men, 10 women) underwent multifrequency MR elastography using a single-shot spin-echo echo planar imaging sequence at 1.5 Tesla and drive frequencies of 40, 50, 60 and 70 Hz. Maps of shear wave speed (c in ms-1) and loss angle (φ in rad), representing stiffness and viscous properties, respectively, were generated using tomoelastography data processing. The volunteers were scanned before and after ingestion of 1,000 mL of 2% mannitol solution as oral contrast agent. There was no significant difference in terminal ileum biomechanical properties before vs. after ingestion of an oral contrast agent (mean c: 1.47±0.24 vs. 1.40±0.25 ms-1 with P=0.37; mean φ: 0.70±0.12 rad vs. 0.68±0.12 rad with P=0.61). Moreover, there was no statistically significant correlation between MR elastography parameters before and after the ingestion of oral contrast (c: r=0.22, P=0.36; φ: r=0.24, P=0.30). The results of this study suggest that bowel distension for intestinal MR elastography has no systematic effect on the biomechanical tissue properties of the terminal ileum determined by MR elastography. Therefore, future study protocols appear feasible with or without oral contrast agents.

Performance and Interpretation of Lung Scintigraphy: An Evaluation of Current Practices in Australia, Canada, France, Germany, and United States.

Although ventilation/perfusion (V/Q) scintigraphy is a widely used imaging test, different options are possible for the acquisition and interpretation of the scan. The aim of this study was to assess current practices regarding the use and interpretation of lung scintigraphy in various clinical indications. An online survey comprising 25 questions was sent to nuclear medicine departments in Australia, Canada, France, Germany, and United States between 2022 and 2023. A single response per department was consolidated. Four hundred nineteen responses were collected (Australia: 32, Canada: 58, France: 149, Germany: 92, and United States: 88). For acute pulmonary embolism (PE) diagnosis, 82.8% of centers reported using SPECT acquisitions (Australia: 93.3%, Canada: 91.8%, France: 99.2%, Germany: 96.2%, and United States: 32.1%). Among them, SPECT images were combined with a CT scan in 70.5% of centers. A total of 10.6% of centers reported not using ventilation for acute PE diagnosis. SPECT acquisition was used in 97.8% of centers using 99m Tc carbon particles, 97.1% 81m Kr gas, 58.7% 99m Tc-DTPA, and 19.4% 133 Xe gas, respectively. For V/Q SPECT interpretation, the EANM criteria were used in 65.0% of departments. A very wide variety of practices were observed in pregnant women and in COVID-19 patients. SPECT acquisition was widely used in the follow-up of PE and for the screening of chronic thromboembolic pulmonary hypertension (>90% of centers), with inconsistency regarding the interpretation of matched perfusion defects in this setting. This survey shows the strong adoption of SPECT in the various clinical indications of lung scintigraphy, except in the United States, where planar imaging is still mostly used. The survey also shows variability in interpretation criteria both for PE diagnosis and screening for chronic thromboembolic pulmonary hypertension, highlighting the need for further standardizations of practices.

Effect of incoming flow conditions on air lubrication regimes

Different air phase regimes are formed by controlled air injection in a spatially developing flat plate turbulent boundary layer (TBL). The air is introduced via a slot type injector without the use of a backward-facing step or cavitator upstream of the air injection position. The effect of different incoming liquid flow characteristics on the different regimes is investigated by varying both the liquid freestream velocity and the incoming TBL thickness. The latter is realized through changing the position of the air injection along the length of the water tunnel facility. That resulted in a downstream distance based Reynolds number from 1 to 5 million. Three different air phase regimes are identified under different air flow rates and freestream velocities: the bubbly regime, the transitional, and the air layer regime. The morphological differences of each one are described and quantitative analysis is performed based on the non-wetted area in each condition. The incoming TBL as well as the flow around the air layer are measured with planar particle image velocimetry. The latter enabled the determination of the air layer thickness. In addition, the ratio of the air layer to the incoming boundary layer thickness tair/δ is also calculated (≈ 0.04 – 0.5). This is a significant dimensionless parameter for scaling, which indicates the extent to which the air layer is embedded within the incoming TBL. Depending on the incoming flow conditions, a two or three branch air layer is formed. The length of the air layer is found to increase with increasing liquid freestream velocities. A good agreement between the air layer length and a half gravity wave predicted by the dispersion relation is found. An increase of the air layer length is observed with a decreasing incoming TBL thickness. This is attributed to a decrease in the local mean velocity at the air–water interface due to the TBL growth. Finally, increasing the incoming TBL thickness delays the onset of the air layer regime.

Evaluating the image quality and local tumor invasion of uterine cancer by MUSE DWI with RPG

Diffusion-weighted imaging (DWI) is widely utilized for evaluating uterine diseases. However, the prevalent technique, single-shot echo planar imaging (ssEPI), is hindered by notable image distortion and low spatial resolution. Therefore, optimizing uterine DWI sequences is vital for improving image quality. To investigate the efficacy of multiplexed sensitivity encoding (MUSE) combined with reverse polarity gradient (RPG) in enhancing uterine DWI quality and assessing local invasion in endometrial and cervical cancer, we included 149 patients. Each patient underwent DWI of the uterus using ssEPI, MUSE, and RPG-MUSE techniques. We compared these three sequences regarding image quality, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), geometric distortion rate (GDR), ADC values, accuracy in determining the extent of cancer invasion, and the Area Under the Curve (AUC) for identifying endometrial cancer and benign endometrial lesions using ADC values. The results indicated that RPG-MUSE DWI had less artifacts than MUSE and ssEPI (P < 0.05). Lesions were more apparent in MUSE and RPG-MUSE sequences compared to ssEPI (P < 0.05), with RPG-MUSE providing clearer lesion edges (P < 0.05). Additionally, RPG-MUSE DWI demonstrated higher SNR and CNR than ssEPI and MUSE (P < 0.05), along with a lower GDR (P < 0.05). The ADC values did not show significant differences among the three sequences (P > 0.05). Furthermore, the AUC of the ROC for detecting endometrial cancer and benign endometrial lesions using ADC values showed no significant differences across the sequences (P = 0.7609, 0.7186, and 0.8706, respectively). When combining each DWI sequence with T2WI for FIGO staging, RPG-MUSE and MUSE exhibited better alignment with pathology findings compared to ssEPI (P < 0.05). Overall, RPG-MUSE DWI showed fewer artifacts, higher SNR and CNR, reduced geometric distortion, and clearer lesion visualization compared to ssEPI and MUSE, leading to a more precise assessment of endometrial and cervical cancer invasion extent.

Incidence of exclusive extrapelvic skeletal metastasis in prostate carcinoma on bone scintigraphy.

Bone is one of the common sites of metastasis from prostate carcinoma. Bone scintigraphy (BS) is one of the most sensitive imaging modalities currently used for bone metastatic work-up. Skeletal metastasis in prostate carcinoma commonly involves pelvic bones but rarely involves extrapelvic-extraspinal sites. To retrospectively analyze the BS data to determine the pattern of skeletal metastases in the prostate carcinoma. This retrospective observational study involves patients with biopsy-proven prostate carcinoma referred for BS for staging assessment. Patients with abnormal BS were evaluated for the pattern of skeletal involvement and data were presented in descriptive format in the form of percentages. A total of 150 patients with biopsy-proven prostate cancer who were referred for staging were included in the study. Thirteen of 150 patients (8.67%) had no abnormal uptake on planar images, ruling out metastatic disease. Twenty-four patients (16%) had heterogeneous uptake in the spine with distribution characteristic of degenerative disease and no scan pattern of metastatic disease. Thirty patients (20%) had multifocal uptake involving both pelvic and extra pelvic bones on planar images typical for skeletal metastasis and were considered metastatic. Eighty-three out of 150 patients (55.3%) had increased tracer uptake, which was indeterminate, thus, single photon emission computed tomography-computed tomography (SPECT-CT) was acquired, which showed 51 with metastatic disease, 31 benign lesions, and one indeterminate finding. Seven of 150 patients had exclusive pelvic bone uptake, which was found to be metastatic in 4/7 patients in SPECT-CT. Fifty six out of 150 patients showed exclusive extrapelvic tracer uptake, of which only 3 had vertebral metastatic disease. None of the patients with increased uptake exclusively in the extrapelvic-extraspinal location was metastatic. The incidence of exclusive extrapelvic skeletal metastatic disease in prostate carcinoma is 2% (excluding one patient with indeterminate findings). Further, none of the patients in the current study had exclusive extrapelvic-extraspinal metastasis. Thus, exclusive extrapelvic-extraspinal focal abnormality on planar BS carries a very low probability of metastatic disease and hence, further imaging or SPECT-CT can be safely avoided in such cases.

Cardiac sympathetic activity and lethal arrhythmic events: insight into bell-shaped relationship between 123I-meta-iodobenzylguanidine activity and event rates

Background123I-meta-iodobenzylguanidine (mIBG) has been applied to patients with chronic heart failure (CHF). However, the relationship between 123I-mIBG activity and lethal arrhythmic events (ArE) is not well defined. This study aimed to determine this relationship in Japanese and European cohorts.ResultsWe calculated heart-to-mediastinum (H/M) count ratios and washout rates (WRs) of 827 patients using planar 123I-mIBG imaging. We defined ArEs as sudden cardiac death, arrhythmic death, and potentially lethal events such as sustained ventricular tachycardia, cardiac arrest with resuscitation, and appropriate implantable cardioverter defibrillator (ICD) discharge, either from a single ICD or as part of a cardiac resynchronization therapy device (CRTD). We analyzed the incidence of ArE with respect to H/M ratios, WRs and New York Heart Association (NYHA) functional classes among Japanese (J; n = 581) and European (E; n = 246) cohorts. We also simulated ArE rates versus H/M ratios under specific conditions using a machine-learning model incorporating 13 clinical variables. Consecutive patients with CHF were selected in group J, whereas group E comprised candidates for cardiac electronic devices. Groups J and E mostly comprised patients with NYHA functional classes I/II (95%) and II/III (91%), respectively, and 21% and 72% were respectively implanted with ICD/CRTD devices. The ArE rate increased with lower H/M ratios in group J, but the relationship was bell-shaped, with a high ArE rate within the intermediate H/M range, in group E. This bell-shaped curve was also evident in patients with NYHA classes II/III in the combined J and E groups, particularly in those with a high (> 15%) mIBG WR and with ischemic, but not in those with non-ischemic etiologies. Machine learning-based prediction of ArE risk aligned with these findings, indicating a bell-shaped curve in NYHA class II/III but not in class I.ConclusionsThe relationship between cardiac 123I-mIBG activity and lethal arrhythmic events is influenced by the background of patients. The bell-shaped relationship in NYHA classes II/III, high WR, and ischemic etiology likely aids in identifying patients at high risk for ArEs.