Material degradation and its mechanism in a plain woven GFRP under biaxial (combined tension-torsion) cyclic loading were studied. A plain woven glass fabric composite using polyester resin was selected for this study. Residual strength and stiffness reduction were observed to estimate the degree of fatigue damage. Based on the cumulative damage mechanics, a damage model to predict the stiffness reduction under biaxial cyclic loading was proposed. An attempt to predict biaxial fatigue life using the proposed model was also made, wherein the concept of the critical damage level was introduced. Experimental results confirmed that the model could predict both stiffness reduction and fatigue life reasonably.