Over an 11-month period, seven isolates of Corynebacterium amycolatum were cultured from urine collected via cystocentesis from a feline patient with relapsing urinary tract infection (UTI). The 11-year-old, castrated male, domestic short-haired cat presented with a history of chronic kidney disease, episodic vomiting and diarrhea, hypercalcemia, obstructive urolithiasis, and grade III parasternal systolic heart murmur. In addition to placing a left-sided subcutaneous ureteral bypass (SUB), we performed a perineal urethrostomy to treat the urinary tract obstruction. Urine sampled 10 months after SUB placement yielded growth of Trueperella abortisuis (>105 CFU/mL) and C. amycolatum (200 CFU/mL; this isolate was not saved). The patient was treated with amoxicillin-clavulanate (62.5 mg PO q12h; 21 days). The urine sampled on days 13 and 26 post treatment (pt) yielded no bacterial growth.