Objectives: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a salvage therapy in patients with severe cardiopulmonary failure. Because large cannulas (16-24F) are necessary to achieve adequate oxygenation, the femoral artery is the most common access site. Unfortunately, femoral cannulation has been associated with limb complications (10%-70%), including ischemia, limb loss, and compartment syndrome. This study aimed to evaluate these complications and management related to limb salvage. Methods: A retrospective review was conducted of 91 consecutive patients requiring VAECMO via femoral cannulation from July 2010 until January 2015. At the time of cannulation, most patients had percutaneous placement of distal arterial perfusion catheters (DPC). After cannulation, all patients were monitored by a near-infrared spectroscopy (NIRS) algorithm and hourly lower extremity examination by trained cardiac intensive care nursing staff, with immediate notification of any change from baseline. ECMO decannulation involved a femoral cutdown with arteriotomy closure by either primary repair or patch angioplasty with bovine pericardium. Study end points included limb ischemia, compartment syndrome requiring fasciotomies, and limb loss. Results: Ninety-one patients were supported with VA-ECMO with femoral arterial cannula sizes from 1624F. Mean length of time on ECMO was 9.1 days (range, 1-40 days). Percutaneous DPC was placed immediately in 62 of 91 patients, with no subsequent ischemia. Of the 29 patients without initial DPC placement, 12 (41.4%; 13.2% of all VA ECMO) developed acute ischemia. Two patients subsequently had DPC placement only, 5 had DPC placement and fasciotomies, 4 had fasciotomies only, and 1 patient required amputation after presenting with acute ischemia after cannulation at another hospital. After DPC placement, all patients had resolution of limb ischemia. The remaining 17 patients without DPC placement experienced no vascular compromise. Overall survival in our VAECMO population was 64%; in patients with limb complications, mortality was 75%. Conclusions: Historically, femoral VA-ECMO has been associated with significant limb ischemic complications. A systematic protocol including NIRS monitoring, trained intensive care nursing staff, DPC placement, decannulation with primary repair of arteriotomies or patch angioplasty can decrease rates of limb ischemia leading to limb loss.
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