Pixelated Cadmium Zinc Telluride Research Articles

Performance evaluation of the 3D-ring cadmium–zinc–telluride (CZT) StarGuide system according to the NEMA NU 1-2018 standard

BackgroundThe application of semi-conductor detectors such as cadmium–zinc–telluride (CZT) in nuclear medicine improves extrinsic energy resolution and count sensitivity due to the direct conversion of gamma photons into electric signals. A 3D-ring pixelated CZT system named StarGuide was recently developed and implemented by GE HealthCare for SPECT acquisition. The system consists of 12 detector columns with seven modules of 16 × 16 CZT pixelated crystals, each with an integrated parallel-hole tungsten collimator. The axial coverage is 27.5 cm. The detector thickness is 7.25 mm, which allows acquisitions in the energy range [40–279] keV. Since there is currently no performance characterization specific to 3D-ring CZT SPECT systems, the National Electrical Manufacturers Association (NEMA) NU 1-2018 clinical standard can be tailored to these cameras. The aim of this study was to evaluate the performance of the SPECT/CT StarGuide system according to the NEMA NU 1-2018 clinical standard specifically adapted to characterize the new 3D-ring CZT.ResultsDue to the integrated collimator, the system geometry and the pixelated nature of the detector, some NEMA tests have been adapted to the features of the system. The extrinsic measured energy resolution was about 5–6% for the tested isotopes (99mTc, 123I and 57Co); the maximum count rate was 760 kcps and the observed count rate at 20% loss was 917 kcps. The system spatial resolution in air extrapolated at 10 cm with 99mTc was 7.2 mm, while the SPECT spatial resolutions with scatter were 4.2, 3.7 and 3.6 mm in a central, radial and tangential direction respectively. Single head sensitivity value for 99mTc was 97 cps/MBq; with 12 detector columns, the system volumetric sensitivity reached 520 kcps MBq−1 cc−1.ConclusionsThe performance tests of the StarGuide can be performed according to the NEMA NU 1-2018 standard with some adaptations. The system has shown promising results, particularly in terms of energy resolution, spatial resolution and volumetric sensitivity, potentially leading to higher quality clinical images.

Unsupervised Learning for Improved Gamma-Ray Spectrometry in Pixelated Cadmium Zinc Telluride (CZT) Detectors

Machine learning has been found to be ubiquitously useful across many industries, presenting an opportunity to improve radiation detection performance using data-driven algorithms. Improved detector resolution can aid in the detection, identification, and quantification of radionuclides. In this work, a novel, data-driven, unsupervised learning approach is developed to improve detector spectral characteristics by learning, and subsequently rejecting, poorly performing regions of the pixelated detector. Feature engineering is used to fit individual characteristic photo peaks to a Doniach lineshape with a linear background model. Then, principal component analysis is used to learn a lower-dimension latent space representation of each photo peak where the pixels are clustered, and subsequently ranked, based on the cluster mean distance to an optimal point. Pixels within the worst cluster(s) are rejected to improve the full-width at half-maximum (FWHM) by 10% to 15% (relative to the bulk detector) at 50% net efficiency when applied to training data obtained from measurements of a 100 μCi 154Eu source using a H3D M400i pixelated cadmium zinc telluride detector. These results compare well with, but do not outperform, a greedy algorithm that accumulates pixels in order of FWHM from lowest to highest used as a benchmark. In the future, this approach can be extended to include the detector energy and angular response. Finally, the model is applied to newly seen natural and enriched uranium spectra relevant for nuclear safeguards applications.

Micro-scale particle tracking using hybrid detectors

Positron Emission Particle Tracking (PEPT) techniques allow the tracking of a radioactive tracer particle moving within a system of flow, enabling non-invasive study of dynamic systems. On the micro-scale, PEPT performance is limited by the achievable activity in radiolabelling a suitable tracer particle, and the fixed geometry of conventional detector systems. To enable application of PEPT towards these scales advanced instrumentation is required, and a hybrid detection system has been developed combining scintillator and semiconductor devices. A bismuth germanate oxide (BGO) scintillator array consisting of 1024 detector elements derived from CTI/Siemens PET scanners (512 pixels of 6.75 x 6.25 x 30 mm3 and 512 pixels of 4.1 x 4.0 x 30 mm3) forms a field of view of 150 x 196 x 101 mm3. A pair of pixelated cadmium zinc telluride room temperature semiconductors (9680 pixels of 1.8 x 1.8 x 0.5 mm3) form a high spatial resolution region of 62 x 42 x 20 mm3 placed within the larger field of view. The design choice maximizes absolute efficiency by merit of the scintillators and enhances spatial resolution through the semiconductors. Energy and timing resolutions of the BGO elements were determined, and sensitivity profiles of the system modelled numerically, enabling the characterization of the system absolute efficiency and spatial resolution. The results suggest the applicability of PEPT in the study of microscale flows for the first time, including investigating flows in capillaries and micro-fluidic devices.

Properties of Redlen cadmium zinc telluride with respect to x-ray spectroscopy

We present a study of a sample pixelated cadmium zinc telluride (CZT) detector using CZT purchased from Redlen Technologies. We demonstrate that the material shows good uniformity across the 2 cm × 2 cm × 3 mm crystal in terms of leakage current, gain, and spectral resolution. We find that the detector produces very good spectral resolution for energies up to at least 105 keV, achieving a full-width at half-maxima of 450 eV at 14 keV up to 880 eV at 105 keV using only single-pixel events. Though our analysis of spectra including multiple-pixel events is somewhat limited, we also produce a spectrum including events in which photon energy is deposited across two adjacent pixels. We find that this degrades the energy resolution by up to 30%, but this result can likely be improved using more rigorous calibrations. Additionally, we investigate depth-of-interaction effects, showing that spectral resolution can be improved by 3% to 7% for energies between 86 and 105 keV by removing events beyond a certain depth. Performing this cut reduces efficiency, removing 13% to 21% of photons from the resulting spectral lines.

Sub-voxel identification of gamma-ray interaction positions within a pixelated CZT detector through signal analysis

Cadmium zinc telluride (CZT) detectors are well suited for use in gamma-imaging applications thanks to their room-temperature operation, excellent energy resolution, and three-dimensional sensitivity to positions of gamma-ray interactions. In many of these applications, the position resolution with which gamma-interactions can be determined is crucial for high quality imaging. Finer pixelisation may provide improved position resolution but at the cost of increased fabrication cost and degradation of spectral performance. This work sets out to instead investigate and quantify the three-dimensional position resolution achievable using pulse shape analysis applied to digital signals, arising from interactions in a CZT detector pixelated into 2 × 2 × 5 mm3 voxels. The signal response of a 3 × 3 pixel cluster has been characterised as a function of gamma-ray interaction position using collimated 57Co and 137Cs sources. Simple pulse shape analysis algorithms using the transient image and charge collection signals have been developed and applied to achieve a sub-voxel position resolution of better than 0.65 × 0.69 × 1.26 mm3 at 122 keV and of 1.06 mm through 5 mm depth at 662 keV, not accounting for divergence of the collimated beam used to evaluate performance. Assessment of the contribution of the diverging gamma-beam placed a lower bound on the achievable positions resolution in 5 mm thickness at 122 keV of 290μm.

Experimental verification of off-axis polarimetry with cadmium zinc telluride detectors of AstroSat-CZT Imager

The cadmium zinc telluride imager (CZTI) on board AstroSat consists of an array of a large number of pixelated cadmium zinc telluride (CZT) detectors capable of measuring the polarization of incident hard x-rays. The polarization measurement capability of CZTI for on-axis sources was experimentally confirmed before the launch. CZTI has yielded tantalizing results on the x-ray polarization of the Crab nebula and pulsar in the energy range of 100 to 380 keV. CZTI has also contributed to the measurement of prompt emission polarization for several gamma-ray bursts (GRBs). However, polarization measurements of off-axis sources such as GRBs are challenging. It is vital to experimentally calibrate the CZTI sensitivity to off-axis sources to enhance the credence of the measurements. In this context, we report the verification of the off-axis polarimetric capability of pixelated CZT detectors through controlled experiments carried out with a CZT detector similar to that used in CZTI and extensive Geant4 simulations of the experimental setup. Our current results show that the CZT detectors can be used to measure the polarization of bright GRBs with off-axis angles of up to ∼60 deg. However, at incidence angles between 45 deg and 60 deg, there might be some systematic effects that need to be taken into account when interpreting the measured polarization fraction.

Incomplete Charge Collection at Inter-Pixel Gap in Low- and High-Flux Cadmium Zinc Telluride Pixel Detectors.

The success of cadmium zinc telluride (CZT) detectors in room-temperature spectroscopic X-ray imaging is now widely accepted. The most common CZT detectors are characterized by enhanced-charge transport properties of electrons, with mobility-lifetime products μeτe > 10−2 cm2/V and μhτh > 10−5 cm2/V. These materials, typically termed low-flux LF-CZT, are successfully used for thick electron-sensing detectors and in low-flux conditions. Recently, new CZT materials with hole mobility-lifetime product enhancements (μhτh > 10−4 cm2/V and μeτe > 10−3 cm2/V) have been fabricated for high-flux measurements (high-flux HF-CZT detectors). In this work, we will present the performance and charge-sharing properties of sub-millimeter CZT pixel detectors based on LF-CZT and HF-CZT crystals. Experimental results from the measurement of energy spectra after charge-sharing addition (CSA) and from 2D X-ray mapping highlight the better charge-collection properties of HF-CZT detectors near the inter-pixel gaps. The successful mitigation of the effects of incomplete charge collection after CSA was also performed through original charge-sharing correction techniques. These activities exist in the framework of international collaboration on the development of energy-resolved X-ray scanners for medical applications and non-destructive testing in the food industry.

Characterisation of cosmic ray induced noise events in AstroSat-CZT imager

The Cadmium Zinc Telluride (CZT) Imager onboard AstroSat consists of pixelated CZT detectors, which are sensitive to hard X-rays above 20 keV. The individual pixels are triggered by ionising events occurring in them, and the detectors operate in a self-triggered mode, recording each event separately with information about its time of incidence, detector co-ordinates, and channel that scales with the amount of ionisation. The detectors are sensitive not only to photons from astrophysical sources of interest, but also prone to a number of other events like background X-rays, cosmic rays, and noise in detectors or the electronics. In this work, a detailed analysis of the effect of cosmic rays on the detectors is made and it is found that cosmic rays can trigger multiple events which are closely packed in time (called ‘bunches’). Higher energy cosmic rays, however, can also generate delayed emissions, a signature previously seen in the PICsIT detector on-board INTEGRAL. An algorithm to automatically detect them based on their spatial clustering properties is presented. Residual noise events are examined using examples of Gamma Ray Bursts as target sources.

Monte Carlo simulation of pixelated CZT detector with Geant4: validation of clinical molecular breast imaging system

Purpose. Molecular breast imaging (MBI) of 99mTc-sestamibi with dual-headed, pixelated, cadmium–zinc–telluride (CZT) detectors is increasingly used in breast cancer care for screening/detecting lesions, monitoring response to therapy, and predicting risk of cancer. MBI as a truly quantitative tool in these applications, however, is limited due the lack of absolute 99mTc-sestamibi uptake quantification. To help advance the field of quantitative MBI, we have developed a Monte Carlo simulation application of the GE Discovery NM 750b system. Methods. Our simulation consists of a two-step process using the Geant4 toolkit to model the detector and source geometry and to track photon interactions and a MATLAB script to model the charge transport within the pixelated CZT detector. Simulated detector and detector response model parameters were selected to match measured and simulated standard performance characteristics using various 99mTc point-, line-, and film-sources in air. The final model parameters were verified by comparing the count profiles, energy spectra, and region of interest counts between simulated and measured images of a breast phantom with two spherical lesions in 5 cm thick medium of air or water. Results. Final performance characteristics with 99mTc sources in air were: (1) energy resolution: 6.1% measured versus 5.9% simulated photopeak full-width at half-maximum (FWHM), (2) spatial resolution: mean error between measured and simulated FWHM of 0.08 mm across 4.4–14.0 mm FWHM range, and (3) sensitivity: 572 cpm/μCi measured versus 567 cpm/μCi simulated (<1% error). Good agreement was observed in the breast phantom line profiles through the spherical lesions and overall energy spectra, with <5% difference in sphere counts between simulated and measured data. Conclusion. A pixelated CZT charge transport and induction model was successfully implemented and validated to simulate imaging with the GE Discovery NM 750b system. This work will enable investigations improving MBI image quality and developing algorithms for uptake quantification.

Evaluation of a variable-aperture full-ring SPECT system using large-area pixelated CZT modules: A simulation study for brain SPECT applications.

Single photon emission computed tomography (SPECT) scanners using cadmium zinc telluride (CZT) offer compact, lightweight, and improved imaging capability over conventional NaI(Tl)-based SPECT scanners. The main purpose in this study is to propose a full-ring SPECT system design with eight large-area CZT detectors that can be used for a broad spectrum of SPECT radiopharmaceuticals and demonstrate the performance of our system in comparison to the reference conventional NaI(Tl)-based two-head Anger cameras. A newly designed full-ring SPECT system is composed of eight large-area CZT cameras (128mm×179.2mm effective area) that can be independently swiveled around their own axes of rotation independently and can have radial motion for varying aperture sizes that can be adapted to different sizes of imaging volume. Extended projection data were generated by conjoining projections of two adjacent detectors to overcome the limited field-of-view (FOV) by each CZT camera. Using Monte Carlo simulations, we evaluated this new system design with digital phantoms including a Derenzo hot rod phantom and a Zubal brain phantom. Comparison of performance metrics such as spatial resolution, sensitivity, contrast-to-noise ratio (CNR), and contrast-recovery ratio was made between our design and conventional SPECT scanners having different pixel sizes and radii of rotation (one clinically well-known type and two arbitrary types matched to our proposed CZT-SPECT geometries). The proposed scanner could result in up to about three times faster in acquisition time over conventional scan time at same acquisition time per step. The spatial resolution improvement, or deterioration, of our proposed scanner compared to the clinical-type scanner was dependent upon the location of the point source. However, there were overall performance improvements over the three different setups of the conventional scanner particularly in volume sensitivity (approximately up to 1.7 times). Overall, we successfully reconstructed the phantom image for both 99m Tc-based perfusion and 123 I-based dopamine transporter (DaT) brain studies simulated for our new design. In particular, the striatal/background contrast-recovery ratio in 3-to-1 reference ratio was over 0.8 for the 123 I-based DaT study. We proposed a variable-aperture full-ring SPECT system using combined pixelated CZT and energy-optimized parallel-hole collimator modules and evaluated the performance of this scanner using relevant digital phantoms and MC simulations. Our studies demonstrated the potential of our new full-ring CZT-SPECT design, showing reduced acquisition time and improved sensitivity with acceptable CNR and spatial resolution.

Room-temperature performance of 3 mm-thick cadmium-zinc-telluride pixel detectors with sub-millimetre pixelization.

Cadmium-zinc-telluride (CZT) pixel detectors represent a consolidated choice for the development of room-temperature spectroscopic X-ray imagers, finding important applications in medical imaging, often as detection modules of a variety of new SPECT and CT systems. Detectors with 3-5 mm thicknesses are able to efficiently detect X-rays up to 140 keV giving reasonable room-temperature energy resolution. In this work, the room-temperature performance of 3 mm-thick CZT pixel detectors, recently developed at IMEM/CNR of Parma (Italy), is presented. Sub-millimetre detector arrays with pixel pitch less than 500 µm were fabricated. The detectors are characterized by good room-temperature performance even at high bias voltage operation (6000 V cm-1), with energy resolutions (FWHM) of 3% (1.8 keV) and 1.6% (2 keV) at 59.5 keV and 122.1 keV, respectively. Charge-sharing investigations were performed with both uncollimated and collimated synchrotron X-ray beams with particular attention to recovering the charge losses at the inter-pixel gap region. High ratemeasurements demonstrated the absence of high-flux radiation-induced polarization phenomena up to 25 × 106 photons mm-2 s-1.

A Monte Carlo study to investigate the feasibility of an on-board SPECT/spectral-CT/CBCT imager for medical linear accelerator.

The on-board flat-panel cone-beam computed tomography (CBCT) lacks molecular/functional information for current online image-guided radiation therapy (IGRT). It might not be adequate for adaptive radiation therapy (ART), particularly for biologically guided tumor delineation and targeting which might be shifted and/or distorted during the course of RT. A linear accelerator (Linac) gantry-mounted on-board imager (OBI) was proposed using a single photon counting detector (PCD) panel to achieve single photon emission computed tomography (SPECT), energy-resolved spectral CT, and conventional CBCT triple on-board imaging, which might facilitate online ART with an addition of volumetric molecular/functional imaging information. The system was designed and evaluated in the GATE Monte Carlo platform. The OBI system including a kV-beam source and a pixelated cadmium zinc telluride (CZT) detector panel mounted on a medical Linac orthogonally to the MV beam direction was designed to obtain online CBCT, spectral CT, and SPECT tri-modal imaging of patients in the treatment room. The spatial resolutions of the OBI system were determined by imaging simulated phantoms. The CBCT imaging was evaluated by a simulated contrast phantom. A PMMA phantom containing gadolinium was imaged to demonstrate quantitative imaging of spectral-CT/CBCT of the system. The capability of tri-modal imaging of the OBI was demonstrated using three different spectral CT imaging methods to differentiate gadolinium, gold, calcium within simulated PMMA and the SPECT to image radioactive 99m Tc distribution. The dual-isotope SPECT imaging of the system was also evaluated by imaging a phantom containing 99m Tc and 123 I. The radiotherapy-related parameters of iodine contrast fraction and virtual non-contrast (VNC) tissue electron density in the Kidney1 inserts of a simulated phantom were decomposed using the Bayesian eigentissue decomposition method for contrast-enhanced CBCT/spectral-CT of the OBI in a single scan. The spatial resolutions of CBCT and SPECT of the OBI were determined to be 15.1lp/cm at 10% MTF and 4.8-12mm for radii of rotation of 10-40cm, respectively. In CBCT image of the contrast phantom, most of the soft-tissue inserts were visible with sufficient spatial structure details. As compared to the CBCT image of gadolinium, the spectral CT image provided higher image contrasts. Calcium, gadolinium, and gold were separated well by using the spectral CT material imaging methods. The reconstructed distribution of 99m Tc agreed with the spatial position within the phantom. The two isotopes were separated from each other in dual-isotope SPECT imaging of the OBI. The iodine fractions and the VNC electron densities were estimated in the iodine-enhanced Kidney1 tissue inserts with reasonable RMS errors. The main procedures of the tri-modal imaging guided online ART workflow were presented with new functional features included. Using a single photon counting CZT detector panel, an on-board SPECT, spectral CT, and CBCT tri-modal imaging could be realized in Linacs. With the added online molecular/functional imaging obtained from the new OBI for the online ART proposed, the accuracy of radiation treatment delivery could be further improved.

A Prototype VP-PET Imaging System Based on Highly Pixelated CdZnTe Detectors.

We investigated a prototype virtual-pinhole positron emission tomography (PET) system for small-animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the insert detectors consisted of 0.6 mm pixelated cadmium zinc telluride (CdZnTe). To validate the imaging experiment, we did a Monte Carlo simulation for the virtual-pinhole PET (VP-PET) system in the Geant4 Application for Emission Tomography (GATE). For a point source of 22Na with a 0.5 mm diameter, the filtered back-projection algorithm-reconstructed PET image showed a resolution of 0.7 mm full-width-at-half-maximum. The system sensitivity was 0.46 cps/kBq at the center of the field view of the PET system with a source activity of 0.925 MBq and an energy window of 350 to 650 keV. A rod source phantom and a Derenzo phantom with 18F were also simulated to investigate the PET imaging ability. GATE simulation indicated that sources with 0.5 mm diameter could be clearly detected using 0.6 mm pixelated CdZnTe detectors as insert devices in a VP-PET system.

Monte Carlo computer simulation of a camera system for proton beam range verification in cancer treatment

Purpose:This paper investigated a framework to efficiently compute and merge Monte Carlo simulations with new technique development in cancer treatment. A newly designed 3-D prompt gamma (PG) camera system was developed using Monte Carlo computer simulation method to validate the utility of the camera simulated for in-beam proton range verification during cancer treatment. Materials and Methods:We used the TOPAS Monte Carlo code to model a 3-D PG slit-camera system based on pixelated cadmium zinc telluride (CZT) semiconductor detectors. The hierarchy structure of the system modeling includes a top level parameter file and a set of low level parameter files needed to specify particle source, physics setting, geometry, scoring, time-dependent motion, data and graphical output of the system. A high-performance computer cluster to perform the time-consuming computing was used. The effectiveness of the Monte Carlo computer simulation for the system modeling was assessed through statistical simulation experiments. The energy spectra detected by the CZT camera were simulated by irradiating a polymethyl methacrylate (PMMA) phantom with a proton beam of 160 MeV. The axial beam shifting within the PMMA phantom and ranges of the distal beam spots of C-Shape dose distribution in the TG-119 phantom were measured by the modeled camera, respectively. Through simulating a double-head slit camera system, the transverse positions of the proton beam spots were determined based on the measurement of time of flights of photons from positron annihilation events induced by protons within patient. Results:The results from the Monte Carlo computer simulation showed that the energy spectra detected by the CZT camera consisted of main characteristic peaks, including the 4.44 MeV peak from de-excitation of 12C and the 511 KeV peak from positron annihilation interaction. The gamma emission between 4.0 to 5.0 MeV contributed to the majority of the detected profiles. In the PMMA phantom experiments with 2.2×108 protons at 160 MeV simulated, a 1 mm standard deviation on range estimation was achieved. With the collimator at 25 cm away from the beam axis, a less than 3 mm standard deviation on range estimation in TG-119 phantom for the individual distal beam spots was obtained. Using the time-of-flight method, the transverse position accuracy of the beam spot measured was less than 1 cm using the simulated double-head camera. Conclusions:The study demonstrated the effectiveness of Monte Carlo computer simulation framework to model the proton beam range monitoring process. Moreover, the computationally modeled proton range verification capability using the 3-D PG camera system, with millimeter accuracy, can be readily translated from computer modeling to medical practice.

An On-Board Spectral-CT/CBCT/SPECT Imaging Configuration for Small-Animal Radiation Therapy Platform: A Monte Carlo Study.

This study investigated the feasibility of a highly specific multiplexed image-guided small animal radiation therapy (SART) platform based on triple imaging from on-board single-photon emission computed tomography (SPECT), spectral-CT, and cone-beam CT (CBCT) guidance in radiotherapy treatment. As a proof-of-concept, the SART system was built with the capability of triple on-board image guidance by utilizing an x-ray tube and a single cadmium zinc telluride (CZT) semiconductor photon-counting imager via a Monte Carlo simulation study. The x-ray tube can be set at a low tube current for imaging mode and a high tube current for radiation therapy mode, respectively. In the imaging mode, both x-ray and gamma-ray projection data were collected by the imager to reconstruct CBCT, SPECT and spectral CT images of small animals being treated. The modulation transfer function (MTF) of the pixelated CZT imager measured was 8.6 lp/mm. The overall performances of the CBCT and SPECT imaging of the system were evaluated with sufficient spatial resolution and imaging quality to be fitted into the SART platform. The material differentiation and decomposition capacities of spectral CT within the system were verified using K-edge imaging, image-based optimal energy weighted imaging, and image-based linear material decomposition methods. The triple imaging capability of the system was demonstrated using a PMMA phantom containing gadolinium, iodine and radioisotope 99mTc inserts. All the probes were clearly identified in the registered image. The results demonstrated that a novel SART platform with high-quality on-board CBCT, spectral-CT, SPECT image guidance is technically feasible by using a single semiconductor imager, thus affording comprehensive image guidance from anatomical, functional, and molecular levels for radiation treatment beam delivery.

Radiation measurement and imaging using 3D position sensitive pixelated CZT detector

Abstract In this study, we evaluated the performance of a commercial pixelated cadmium zinc telluride (CZT) detector for spectroscopy and identified its feasibility as a Compton camera for radiation monitoring in a nuclear power plant. The detection system consisted of a 20 mm × 20 mm × 5 mm CZT crystal with 8 × 8 pixelated anodes and a common cathode, in addition to an application specific integrated circuit. The performance of the various radioisotopes 57Co, 133Ba, 22Na, and 137Cs was evaluated. In general, the amplitude of the induced signal in a CZT crystal depends on the interaction position and material non-uniformity. To minimize this dependency, a drift time correction was applied. The depth of each interaction was calculated by the drift time and the positional dependency of the signal amplitude was corrected based on the depth information. After the correction, the Compton regions of each spectrum were reduced, and energy resolutions of 122 keV, 356 keV, 511 keV, and 662 keV peaks were improved from 13.59%, 9.56%, 6.08%, and 5%–4.61%, 2.94%, 2.08%, and 2.2%, respectively. For the Compton imaging, simulations and experiments using one 137Cs source with various angular positions and two 137Cs sources were performed. Individual and multiple sources of 133Ba, 22Na, and 137Cs were also measured. The images were successfully reconstructed by weighted list-mode maximum likelihood expectation maximization method. The angular resolutions and intrinsic efficiency of the 137Cs experiments were approximately 7°–9° and 5 × 10−4–7 × 10−4, respectively. The distortions of the source distribution were proportional to the offset angle.

Cadmium zinc telluride pixel detectors for high-intensity x-ray imaging at free electron lasers

This paper reports the first demonstration of high-intensity x-ray imaging using cadmium zinc telluride (CdZnTe) pixel detectors at a free electron laser (FEL). Prototype detectors were produced using the STFC large pixel detector (LPD) ASIC and sensors fabricated from a novel high-intensity-capable CdZnTe material produced by Redlen Technologies. Characterisation of the performance of this sensor material was completed at the Linac Coherent Light Source (LCLS) FEL. The detectors were operated at a frame rate of 1 MHz with 9.5 keV x-ray pulses delivered at a rate of 120 Hz. Measurements successfully demonstrated the linear response of the CdZnTe material to increasing numbers of x-rays up to a fluence of 8 GeV mm−2 per pulse, the limit of the dynamic range of the LPD ASIC.

Dual-polarity pulse processing and analysis for charge-loss correction in cadmium-zinc-telluride pixel detectors.

Charge losses at the inter-pixel gap are typical drawbacks in cadmium-zinc-telluride (CZT) pixel detectors. In this work, an original technique able to correct charge losses occurring after the application of charge-sharing addition (CSA) is presented. The method, exploiting the strong relation between the energy after CSA and the beam position at the inter-pixel gap, allows the recovery of charge losses and improvements in energy resolution. Sub-millimetre CZT pixel detectors were investigated with both uncollimated radiation sources and collimated synchrotron X-rays, at energies below and above the K-shell absorption energy of the CZT material. The detectors are DC coupled to fast and low-noise charge-sensitive preamplifiers (PIXIE ASIC) and followed by a 16-channel digital readout electronics, performing multi-parameter analysis (event arrival time, pulse shape, pulse height). Induced-charge pulses with negative polarity were also observed in the waveforms from the charge-sensitive preamplifiers (CSPs) at energies >60 keV. The shape and the height of these pulses were analysed, and their role in the mitigation of charge losses in CZT pixel detectors. These activities are in the framework of an international collaboration on the development of energy-resolved photon-counting systems for spectroscopic X-ray imaging (5-140 keV).

Digital fast pulse shape and height analysis on cadmium-zinc-telluride arrays for high-flux energy-resolved X-ray imaging.

Cadmium-zinc-telluride (CZT) arrays with photon-counting and energy-resolving capabilities are widely proposed for next-generation X-ray imaging systems. This work presents the performance of a 2 mm-thick CZT pixel detector, with pixel pitches of 500 and 250 µm, dc coupled to a fast and low-noise ASIC (PIXIE ASIC), characterized only by the preamplifier stage. A custom 16-channel digital readout electronics was used, able to digitize and process continuously the signals from each output ASIC channel. The digital system performs on-line fast pulse shape and height analysis, with a low dead-time and reasonable energy resolution at both low and high fluxes. The spectroscopic response of the system to photon energies below (109Cd source) and above (241Am source) the K-shell absorption energy of the CZT material was investigated, with particular attention to the mitigation of charge sharing and pile-up. The detector allows high bias voltage operation (>5000 V cm-1) and good energy resolution at moderate cooling (3.5% and 5% FWHM at 59.5 keV for the 500 and 250 µm arrays, respectively) by using fast pulse shaping with a low dead-time (300 ns). Charge-sharing investigations were performed using a fine time coincidence analysis (TCA), with very short coincidence time windows up to 10 ns. For the 500 µm pitch array (250 µm pitch array), sharing percentages of 36% (52%) and 60% (82%) at 22.1 and 59.5 keV, respectively, were measured. The potential of the pulse shape analysis technique for charge-sharing detection for corner/border pixels and at high rate conditions (250 kcps pixel-1), where the TCA fails, is also shown. Measurements demonstrated that significant amounts of charge are lost for interactions occurring in the volume of the inter-pixel gap. This charge loss must be accounted for in the correction of shared events. These activities are within the framework of an international collaboration on the development of energy-resolved photon-counting systems for high-flux energy-resolved X-ray imaging (1-140 keV).

Characterisation of a CZT detector for dosimetry of molecular radiotherapy

A pixelated cadmium zinc telluride (CZT) detector has been characterised for the purpose of developing a quantitative single photon emission computed tomography (SPECT) system for dosimetry of molecular radiotherapy (MRT). This is the aim of the Dosimetric Imaging with CZT (DEPICT) project, which is a collaboration between the University of Liverpool, The Royal Marsden Hospital, The Royal Liverpool and Broadgreen University Hospital, and the commercial partner Kromek. CZT is a direct band gap semiconductor with superior energy resolution and stopping power compared to scintillator detectors used in current SPECT systems. The inherent detector properties have been investigated and operational parameters such as bias voltage and peaking time have been selected to optimise the performance of the system. Good energy resolution is required to discriminate γ-rays that are scattered as they are emitted from the body and within the collimator, and high photon throughput is essential due to the high activities of isotopes administered in MRT. The system has an average measured electronic noise of 3.31 keV full width at half maximum (FWHM), determined through the use of an internal pulser. The energy response of the system was measured across the energy region of interest 59.5 keV to 364.5 keV and found to be linear. The reverse bias voltage and peaking time producing the optimum FWHM and maximum photon throughput were 600 V and 0.5 μs respectively. The average dead time of the system was measured as 4.84 μs and charge sharing was quantified to be 0.71 % at 59.5 keV . A pixel sensitivity calibration map was created and planar images of the medical imaging isotopes 99mTc and 123I were acquired by coupling the device to a prototype collimator, thereby demonstrating the suitability of the detector for the DEPICT project.