Event Abstract Back to Event Pituitary adenylate cyclase activating polypeptide is protective against oxidative stress in human retinal pigment epithelial cells Laszlo Mester1, Krisztina Kovács1, Boglárka Rácz1, Alíz Szabó1, Tamas Atlasz2, Krisztina Szabadfi3 and Dóra Reglodi4* 1 University of Pecs, Department of Biochemistry and Medical Chemistry, Hungary 2 University of Pecs, Department of Sportbiology, Hungary 3 University of Pecs, Department of Experimental Zoology and Neurobiology, Hungary 4 University of Pecs, Department of Anatomy, Hungary Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with potent neurotrophic and neuroprotective effects. We have previously shown that PACAP protects against several types of retinal injuries in vivo, including retinal ischemia, glutamate-induced excitotoxicity, UVA-induced lesion and diabetic retinopathy. We have also shown that PACAP activates antiapoptotic pathways and inhibits proapoptotic signaling in retinal lesions in vivo. PACAP receptors have been identified on the retinal pigment epithelial cells and PACAP has been shown to inhibit interleukin secretion from pigment epithelial cells. It is not known, however, whether PACAP is protective in these cells. Human retinal pigment epithelial cells (ARPE-19 cell line) was exposed to in vitro oxidative stress by hydrogen peroxide. Cell survival was significantly higher in PACAP-treated cells, as shown by MTT test. Furthermore, oxidative stress induced apoptosis, which was decreased by PACAP treatment, as detected by flow cytometry. In summary, these results show, for the first time, that PACAP is protective in the retinal pigment epithelial cells. Support: OTKA K72592, CNK78480, Richter Foundation, Bolyai Scholarship, PTE AOK Research Grant 2009, ETT 278-04/2009 Conference: IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010. Presentation Type: Poster Presentation Topic: Sensory and motor systems Citation: Mester L, Kovács K, Rácz B, Szabó A, Atlasz T, Szabadfi K and Reglodi D (2010). Pituitary adenylate cyclase activating polypeptide is protective against oxidative stress in human retinal pigment epithelial cells. Front. Neurosci. Conference Abstract: IBRO International Workshop 2010. doi: 10.3389/conf.fnins.2010.10.00258 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 May 2010; Published Online: 05 May 2010. * Correspondence: Dóra Reglodi, University of Pecs, Department of Anatomy, Pecs, Hungary, dora.reglodi@aok.pte.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Laszlo Mester Krisztina Kovács Boglárka Rácz Alíz Szabó Tamas Atlasz Krisztina Szabadfi Dóra Reglodi Google Laszlo Mester Krisztina Kovács Boglárka Rácz Alíz Szabó Tamas Atlasz Krisztina Szabadfi Dóra Reglodi Google Scholar Laszlo Mester Krisztina Kovács Boglárka Rácz Alíz Szabó Tamas Atlasz Krisztina Szabadfi Dóra Reglodi PubMed Laszlo Mester Krisztina Kovács Boglárka Rácz Alíz Szabó Tamas Atlasz Krisztina Szabadfi Dóra Reglodi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.