ObjectivesThis prospective cohort study aimed to examine the association between chronotype with nutritional and psychosocial factors in pregnant women. MethodsChronotype of the subjects was determined using Morningness-Eveningness Questionnaire (MEQ), whereby higher scores indicate greater morningness. Sleep quality and psychological distress were assessed using the Pittsburgh Sleep Quality Index questionnaire (PSQI) and Depression, Anxiety and Stress Scale (DASS-21) respectively. Pedometer was used to measure 5-day physical activity. Pre-pregnancy weight and height were self-reported. ResultsTo date, 100 pregnant women were approached at selected government maternal and child clinics in Kuala Lumpur, Malaysia. Subjects were mostly Malay (67%). Mean age was 28 (4.3) years; 12% were underweight and 19% were overweight/obese before pregnancy. Stress, anxiety, and depression of moderate severity or above were found in 13%, 49%, and 12% of the subjects, respectively. The prevalence of poor sleepers was 70%. Sedentary behaviour was observed in 73% of the subjects (4086 ± 2247 steps/day). In the linear regression model, chronotype was a significant predictor of stress (2 = –0.421, p = 0.015) and depression (β = –0.208, p = 0.042) during pregnancy. ConclusionsPreliminary findings from this study suggested that chronobiological approaches may be important to tackle psychological distress during pregnancy, which may impact birth outcomes and subsequently, infant growth. The circadian rhythm of subjects will be determined based on salivary hormone in the upcoming analysis. Funding SourcesMinistry of Higher Education, Malaysia. The funds were provided through the Fundamental Research Grant Scheme (FRGS/1/2018/SKK06/UCSI/02/2).