Tests have been performed in a biaxial pipe test cell to develop baseline information on profiled pipe behavior under biaxial loading. These include a lined corrugated high-density polyethylene pipe and a helically wound ribbed polyvinyl chloride pipe. Results of the tests are utilized to examine the effectiveness of the two-dimensional methods of buried pipe analysis. Calculations of pipe responses by the two-dimensional finite element method and a set of simplified design equations are compared with the measurements of pipe strains and deflections. The study reveals that the two-dimensional finite element analysis can effectively be used to calculate pipe deflections and circumferential strains. The simplified equations appear suitable as design tools for standard buried thermoplastic pipe installations. Janbu’s nonlinear soil model with Mohr–Coulomb plasticity provided an effective simulation of the nonlinear soil behavior A study of pipes with low stiffness soil support under the haunches shows that this leads to strain concentrations in the pipe walls near that zone. Higher values of empirical strain factor, Df, are estimated to include this strain concentration during design.