Injection Of Pingyangmycin Research Articles

Local injection of pingyangmycin plus dexamethason in treatment of infant hemangioma

目的 探讨平阳霉素+地塞米松局部注射治疗婴幼儿血管瘤的疗效.方法将平阳霉素8 mg+地塞米松5 mg+2%利多卡因1～2 ml+生理盐水3～8 ml稀释后,行血管瘤内注射至肿胀发白为限,1次平阳霉素用量不超过8 mg.观察2周,视瘤体颜色及硬度决定是否继续用药,直至瘤体开始变硬萎缩为止,平阳霉素注射总量不超过40 mg.近两年来,用该方法治疗1～8个月龄婴幼儿体表增生期血管瘤36例,其中颜面部24例,胸部3例,背部2例,上肢5例,足2例;草莓状血管瘤30例,混合型血管瘤6例.血管瘤最小面积0.6 cm×1.2 cm,最大面积23.0 cm×12.0 cm.结果1次注射治愈2例,2～3次注射治愈25例,4～5次治愈9例,其中局部坏死1例(为足背足底大面积草莓状血管瘤),经换药及手术愈合.随访6～19个月,未见复发,除1例遗留瘢痕外,其余全部无瘢痕愈合.有效率达100%.结论平阳霉素+地塞米松局部注射治疗婴幼儿血管瘤,具有疗效显著、简便易行、安全可靠等优点,是治疗增生期血管瘤首选方法之一,值得推广。

Sclerotherapy of oral and facial venous malformations with use of pingyangmycin and/or sodium morrhuate

Two hundred and sixty patients with oral and facial venous malformations received intralesional injections of either pingyangmycin, sodium morrhuate, or pingyangmycin alternating with sodium morrhuate. Results were rated excellent, good, fair, or poor, depending on clinical outcome. The prevalence of an “excellent” rating in the combined sclerotherapy group (82%) was higher than that in the pingyangmycin group (71%) and the sodium morrhuate group (61%). Swelling and pain following injection were commonly associated with the use of sodium morrhuate. Sclerotherapy with pingyangmycin or sodium morrhuate is an effective and safe treatment for oral and facial venous malformations. Alternate injection of pingyangmycin and sodium morrhuate appears to be more effective for venous malformations than using sclerosant alone.

Histological Investigation of Veins and Venous Malformations after Injection of Sclerosing Agents

Objectives: To study the histological changes of veins and venous malformations after injection of pingyangmycin and sodium morrhuate.Study Design: Pingyangmycin and sodium morrhuate were injected into the marginal auricular veins of the left and right ears of rabbits and histological changes in vessels were observed. Surgical excision of clinical venous malformations in the oral and facial regions was performed for 25 patients after sclerotherapy. The histological changes in the resected lesions were observed.Results: After pingyangmycin injection, obvious changes of veins and venous malformations occurred. Endothelial cells were swollen and vacuolised, tunica intima was discontinuous, thickness of the vessel wall was increased, and lumen was narrowed and occluded. Following injection of sodium morrhuate, intraluminal thrombus was formed and organised, the lumen was obstructed, and a strong inflammatory reaction was observed in nearby tissues.Conclusions: Injection of pingyangmycin and sodium morrhuate into veins and venous malformations can cause injury to endothelial cells, thickening of the vessel wall, and narrowing or occlusion of vessels. Pingyangmycin leads to less inflammatory reaction in extravascular tissues than sodium morrhuate.