Objective To investigate the mechanical responses by the cervical spinal cord to the hyperextension injury under different loading conditions. Methods A three dimensional finite element model of the cervical spinal cord was built and imported into the preprocessor of the Ansys software for assigning boundary and different loading conditions. Then the extension and pinching conditions were simulated after the solution module was entered. The stress results of 9 different anatomical regions in the cross-section of the cervical spinal cord were read and analyzed in the postprocessor of the Ansys software. Results The localized stress mainly occurred at the anterior horn and posterior horn in the gray matter, the anterior funiculus, the medial part of the lateral funiculus, and the lateral part of the posterior funiculus, with the average magnitude decreasing successively. The magnitude of the stress increased with the severity of the cervical spine injury. The maximum stress increment occurrred at the anterior horn. Significant differences in the stress increment were observed between the anterior horn and the lateral funiculus( P 0. 05). Conclusions The cervical hyperextension injury mainly leads to injury to the motor neuron of the anterior horn. More damage to the motor neuron dominating the intrinsic muscle of hand can lead to poorer prognosis. A greater injury load may cause stress to distribute onto more adjacent white matter. Key words: Spinal cord injuries; Finite element analysis; Biomechanics