Prominent among the pyroclastic deposits of Santorini are several thick, widespread lithic breccia deposits, which are found in intimate association with ignimbrite. At least three of these breccias are interpreted, on the basis of field and grain-size criteria, as having originated by the segregation of lithic clasts from active pyroclastic flows. They therefore record the occurrence of three large, previously unrecognized ignimbrite-forming eruptions of the volcano. The breccias of the 18,500 yr. B.P. Cape Riva eruption include two types. The first type is a thin, basal ground breccia, which overlies a strong erosion surface. This breccia shows pinch and swell structures and is strongly enriched in lithic and crystal components. It is considered to have formed by strong fluidization due to incorporation of air into the head of an active pyroclastic flow. The second, and predominant, type consists of thick co-ignimbrite lag breccias (up to 25 m), which overlie the ground breccia. These deposits are generally clast-supported, poorly sorted breccias which in places grade both vertically and laterally into non-welded pumiceous ignimbrite. They consist of well-defined, normally graded units which show coarse tail grading of lithic and pumice clasts. Each breccia unit is underlain by a thin, inversely graded ignimbrite basal layer, and correlates laterally with a flow unit of the associated ignimbrite. The lag breccias are therefore thick equivalents of the 2b lithic concentration zones of Sparks et al. The lag breccias and ignimbrite contain abundant lithic segregation structures that are characteristic of strong gas fluidization. These structures, the presence of basal layers, and the gradation into normal ignimbrite, suggest that the lag breccias originated by the segregation of lithic clasts within the bodies of dense, but strongly fluidized pyroclastic flows. The Cape Riva breccias occur within a few kilometers of their source vent and are interpreted as proximal facies of their associated ignimbrite. The presence of the ground breccia indicates that within this distance, the pyroclastic flows had developed the head and body regions characteristic of gravity currents. The deflation of the pyroclastic flow bodies, within a few kilometers from source, to particle concentrations sufficient to permit the generation of basal layers and coarse tail grading, is incompatible with present theories of column collapse. It is postulated that high pressures at the base of the collapsing Cape Riva eruption column were sufficient to significantly compress the dilute particle-gas mixture of the column close to the source vent. Subsequent sedimentation, as the pyroclastic flows moved laterally, increased the density further to the point where the observed sedimentary features could form. Simultaneous decompression of the gas phase resulted in strong fluidization, and the segregation of the lag breccias.