In the frame of the EU GITEC-TWO Project (Genesis and Impact of Tsunamis on the European Coasts: Tsunami Warning and Observations) one of the main goals is the development and installation of a pilot Tsunami Warning System (TWS) station in Italy. The Ionian Sea region watering the eastern coast of Sicily (southern Italy) experienced large tsunamis in the past and has been identified and selected for the Italian TWS station installation. Most of the existing examples of TWS already available around the world are appropriate for tsunamis that are produced by earthquakes with source areas located tens or hundreds kilometers offshore, but they are not efficient for local tsunamigenic earthquakes. However, in the Mediterranean region most tsunamis are generated very locally and waves attack the coast at most within 5–10 minutes after the shock. Consequently, our system is conceived for those coastlines potentially affected by tsunamis generated by coastal earthquakes and is designed for an immediate detection and an early warning.