In Europe, in the last 3 decades, there has been a constant increase in litter size due to the use of superior maternal line genetics. Those sows giving birth to more piglets than their average number of functional teats are identified as hyperprolificsows(HPS). The large number of piglets born within a litter implies not only a challenge for their access to vital resources like colostrum and milk but has a direct effect on their average birth weight and heterogeneity. These conditions are detrimental to piglets' vitality in the first hours of life and also to their immunity development. An exceptionally large number of growing fetuses in HPS leads to intrauterine crowding and consequently to an increased number of piglets suffering from intrauterine growth retardation (IUGR), which put piglets at a high risk of mortality after birth and up to later stages of life. Increased heterogeneity of birth weight within large litters increases the competition for colostrum intake, with the smaller piglets being less competitive and vital, and therefore affecting negatively their immunity. Low birth weight, long interval to reach the udder, and long duration of farrowing, all have negative effects on piglets' immunoglobulin absorption. In HPS litters, colostrum management should be focused on low birth weight piglets, anticipating their impaired capabilities associated with ingesting adequate colostrum, by shortening the time to reach the udder and reducing competition among piglets. The vitality of neonate piglets, especially low in birth weight or affected by IUGR should be enhanced to improve their body temperature and their early life stage energy metabolism.