The architecture that the Renaissance artists depicted in their works constitutes a vast reservoir of formal solutions that influenced (and were reciprocally influenced by) built architecture. Generally painted according to a rigorous perspective structure, most painted architecture can be restituted and modelled to become part of the Virtual Heritage that develops and extends its knowledge to a wider range of people and scholars. These procedures are here applied to some of the works of Pietro Perugino and Raffaello, a master and his student, in order to define their specific approach to composition, perspective, and architecture. The application of these procedures produced some primary results—the architecture restitutions in plan and elevation or section—and some secondary results concerning the way painted architecture was conceived, represented in perspective, and received as well as it was related to actual architecture.