Pieces Of Evidence Research Articles

Multiple, speeded assessments: Initial evidence on subgroup differences and applicant perceptions

AbstractRecently, shorter assessments have emerged as potential alternatives for more resourceful traditional selection approaches. Multiple, speeded assessments (MSAs) represent such an alternative. In MSAs, candidates participate in a large number of short (a maximum of 5 min), behavioral simulations in which they face a variety of job situations. Initial psychometric evidence on the validity of MSAs is promising. Yet, validity represents only one piece of evidence. It is not known whether MSAs disadvantage specific subgroups, which may inhibit diversity. There is also no information on candidates' experience of going through an MSA, which is pivotal for the attractiveness of the organization's selection process. Therefore, this study investigates an MSA in terms of subgroup differences (gender and nationality) and applicant perceptions. Master of Business Administration (MBA) students (N = 96) proceeded through 18 short role‐plays sampling junior management situations. Score differences between men and women were negligible. Yet, there were large score differences between national citizens and foreigners. There was no evidence for predictive bias for nationality, though. Of the applicant reaction measures, interpersonal treatment perceptions contributed most to overall fairness perceptions. These findings add to the evidence in support of MSAs, while also stressing to remain vigilant for potential score differences among subgroups.

Conservatism and its determinants for Portuguese small and medium entities

In this study, we aim at analyzing whether Portuguese small and medium entities (SMEs) are accounting conservatively and what the determinants for conservatism are. While conservatism remains on accounting for a long time, both within the local accounting standards and IFRS firms may opt for a revaluation model to subsequently measure fixed assets. As the number of assets may be carried to higher values than firm becomes less conservative. Therefore, we propose that revaluations are a negative proxy for conservatism. We find that revaluations are not used in an often manner and they are higher for listed than for unlisted firms. Furthermore, our results suggest that debt and firm size are both positively associated with conservatism. Both associations are more significant for listed than non-listed firms. In addition, return on equity tends to increase conservatism, but only for the most indebted unlisted firms. These pieces of evidence are consistent with conservatism being a mechanism to regulate managers’ activity and to capture the confidence of stakeholders.

Substantial relation between the bacterial biofilm and oncogenesis progression in host.

Globally, bacteria are well-known microorganisms for bacterial biofilm infection. Bacterial biofilm has generated antibiotic resistance and led the persistent infection. But new complications arise with a biofilm that bacterial biofilm shows the new association with oncogenesis. Some bacteria have a carcinogenic nature at the chronic infection stage like Salmonella Typhi, Helicobacter pylori. Thus, biofilm has a significant role in oncogenesis. Few pieces of evidence also support that the bacterial biofilm has a potential role to develop oncogenesis in the human body. Bacterial biofilm is responsible to induce chronic inflammation and is the main basis for the oncogenesis process. But bacterial biofilm association with the oncogenesis mechanism is unknown yet. This article focuses on the function of bacterial biofilm in tumor formation and the mechanism that encourages the oncogenesis and provide a possible and interesting hypothesis involved in between biofilm and host oncogenesis progression. The discussed relationship will provide a sound direction in the field of oncology and concept may give an informative direction in diagnosis and treatment. Bacterial biofilm behavior could be significantly linked with cancer cell formation. This article attracts the attention of researchers of the field because biofilm mediated oncogenesis further indicate towards an important issue in human health.

Angiotensinergic neurotransmission in the bed nucleus of the stria terminalis is involved in cardiovascular responses to acute restraint stress in rats.

The brain angiotensin II acting via AT1 receptors is a prominent mechanism involved in physiological and behavioral responses during aversive situations. The AT2 receptor has also been implicated in stress responses, but its role was less explored. Despite these pieces of evidence, the brain sites related to control of the changes during aversive threats by the brain renin-angiotensin system (RAS) are poorly understood. The bed nucleus of the stria terminalis (BNST) is a limbic structure related to the cardiovascular responses by stress, and components of the RAS system were identified in this forebrain region. Therefore, we investigated the role of angiotensinergic neurotransmission present within the BNST acting via local AT1 and AT2 receptors in cardiovascular responses evoked by an acute session of restraint stress in rats. For this, rats were subjected to bilateral microinjection of either the angiotensin-converting enzyme inhibitor captopril, the selective AT1 receptor antagonist losartan, or the selective AT2 receptor antagonist PD123319 before they underwent the restraint stress session. We observed that BNST treatment with captopril reduced the decrease in tail skin temperature evoked by restraint stress, without affecting the pressor and tachycardic responses. Local AT2 receptor antagonism within the BNST reduced both the tachycardia and the drop in tail skin temperature during restraint. Bilateral microinjection of losartan into the BNST did not affect the restraint-evoked cardiovascular changes. Taken together, these data indicate an involvement of BNST angiotensinergic neurotransmission acting via local AT2 receptors in cardiovascular responses during stressful situations.

GDReBase: A Knowledge Base for Relations between Human Gut Microbes and Diseases Based on Deep Learning

Gut microbes play a prominent role in many aspects of human health, as seen through the increasing number of related studies. The accumulation of intestinal-flora-related studies enables us to better understand the various relationships between human gut microbes and other factors that affect the human body. However, the existing database does not meet the requirements of scientists to browse or retrieve the latest and most comprehensive published data. Thus, a knowledge base containing data related to gut microbes with updates occurring in real time would be highly valuable. We present a knowledge base of consistently curated relationships between human gut microbes and disease. By continuously and automatically collecting papers published in mainstream journals and using deep learning and NLP methods for entity relationship identification, GDReBase has now integrated 3674 diseases, 687 microbes, 7068 relationships, and 13,553 pieces of evidence from 518,286 papers, a figure that will continue to grow. GDReBase is a convenient and comprehensive resource for gut microbiology research and can be accessed free of charge.

Enterobacter sp. biofilm at the air-water interface promotes carbonate precipitation

Biofilm capable of carbonate mineralization can create supersaturated carbonate microenvironment around it. However, the contribution of biofilms in microbially-induced carbonate precipitation is still unclear. In this study, ammonification-driven carbonate precipitation of Enterobacter sp. generated biofilm at the gas-liquid interface of the medium during standing culture, and a mechanical method was applied to destroy biofilms, and the effect of biofilm composed of Enterobacter sp. at the air-water interface on the formation of carbonate were investigated by comparing whether biofilm was disrupted or not. It was found that biofilm destruction inhibited carbonate formation, which was reflected in the delay of the occurrence of mineral formation time point from day 4 to day 6 during the 10-day mineralization experiment, meanwhile, the mineral mass decreased by about 50% compared with the biofilm was not destroyed at day 10. The phenomenon of mineral formation around biofilm suggested that biofilms was more suitable for the formation of carbonate minerals. Those pieces of evidence indicated that the Enterobacter sp. biofilm at the gas-liquid interface accelerated carbonate precipitation. In addition, a particular form of concave spherical calcite was found only around biofilms. This result has value for the interpretation of the morphology of carbonate induced by microorganisms.

Accelerated Canine Retraction by Using Mini Implant With Low-Intensity Laser Therapy.

Background The continuous increase in demand for reduced treatment times has led researchers to think in terms of "accelerated orthodontics." Generally, the duration for fixed orthodontic treatment is around two to three years. Prolonged use of braces leads to external root resorption, a high risk of caries, and decreased patient compliance. Therefore, finding an optimal supplementary approach to achieve faster tooth movement is still considered a subject of interest. Low-intensity laser therapy (LILT) is one of the non-invasive surgical techniques in the field of accelerated orthodontics. Low-level laser therapy (LLLT) has demonstrated faster healing, less bleeding, and biostimulation and anti-inflammatory effects. According to all studies, it accelerates tooth movement, thereby reducing braces treatment time. It is simple, safe, and minimally invasive. Despite these pieces of evidence, studies have shown variable findings in low-level laser therapy. This study evaluates the effect of LLLT on accelerated orthodontics in comparison with conventional canine retraction. An aluminum gallium arsenide-type diode laser with a wavelength of 940 nm has been used in this study. Methodology This study was conducted using the split-mouth method, which included 20 patients with permanent dentition who required first premolar extractions. A miniscrew implant was placed on both the right and left sides for maximum anchorage. Irradiation doses were applied on days 0, 3, 7, and 14 of the first month. Subsequently, irradiations were given every 15 days until the canine's retraction was complete in the test group. Results The study results three months after the canine retraction in the test and control groups (M1) were 0.81 ± 0.03 mm/month and 0.74 ± 0.04 mm/month, respectively, indicating a significantly higher rate of canine retraction in the test group than in the control group (P < 0.0001). The average increase in the amount of tooth movement at three months was 40.1% and 36.3% in the test and control groups, respectively. However, the average increase in the amount of movement of teeth following canine retraction was 100% in the test group and 68.2% in the control group. There were significant variations in the pain score between Day 1 and Day 3 (P = 0.003) in the test group; however, there was no analytic variation in the pain score between Day 1 and Day 30 in the test group (P = 0.18). The pain score between Day 3 and Day 30 was significantly lower. Conclusions It was concluded that the rate of canine retraction increases when it is combined with LILT-assisted accelerated orthodontics in comparison to conventional canine retraction. Although LLLT does not provide immediate pain relief, it relieves the sensation of pain after 24-72 hours. LILT is an innovative, non-invasive technique that allows rapid orthodontic tooth movement. The rate of canine retraction increases when it is combined with LILT-assisted accelerated orthodontics in comparison to conventional canine retraction using mini-implants.

Causes and trends of adult mortality in southern Ethiopia: an eight-year follow up database study

BackgroundBroad and specific causes of adult mortalities are often neglected indicators of wellbeing in low-income countries like Ethiopia due to lack of strong vital statistics. Thus, this database study aimed to assess the causes of adult mortality using demographic surveillance data.MethodsAn 8-year (12 September 2009–11 September 2017) surveillance data from the Arba Minch Health and Demographic Surveillance Site was used for this study. Verbal autopsy methods and ICD codes were used to identify the causes of the adult deaths. The collected data were entered to the database by data clerks. We used Microsoft Excel and STATA version 16 software for data cleaning and analysis. Chi-squared test was used to see the significances of the trend analyses.ResultFrom the 943 adult deaths from 2009 to 2017 in the Health and Demographic Surveillance Site in southern Ethiopia, more than half of them were females. The specific leading cause of death in the adults were tuberculosis (16.8%), malaria (9.7%), and intestinal infectious diseases (9.6%).Communicable diseases (49.2%, 95% C.I 45.7, 52.7) accounted for about half of the deaths followed by non-communicable diseases (35%, 95% C.I 31.7, 38.4) where both categories showed an increasing trend.ConclusionAlthough pieces of evidences are showing the shift from communicable diseases to non-communicable diseases as the major causes of adult death in developing countries, this study showed that communicable diseases are still the major causes of adult deaths. Efforts and emphasis should be given to control infectious diseases such as tuberculosis and malaria.

Dark Coincidences: Small-Scale Solutions with Refracted Gravity and MOND

General relativity and its Newtonian weak field limit are not sufficient to explain the observed phenomenology in the Universe, from the formation of large-scale structures to the dynamics of galaxies, with the only presence of baryonic matter. The most investigated cosmological model, the ΛCDM, accounts for the majority of observations by introducing two dark components, dark energy and dark matter, which represent ∼95% of the mass-energy budget of the Universe. Nevertheless, the ΛCDM model faces important challenges on the scale of galaxies. For example, some very tight relations between the properties of dark and baryonic matters in disk galaxies, such as the baryonic Tully–Fisher relation (BTFR), the mass discrepancy–acceleration relation (MDAR), and the radial acceleration relation (RAR), which see the emergence of the acceleration scale a0≃1.2×10−10 m s−2, cannot be intuitively explained by the CDM paradigm, where cosmic structures form through a stochastic merging process. An even more outstanding coincidence is due to the fact that the acceleration scale a0, emerging from galaxy dynamics, also seems to be related to the cosmological constant Λ. Another challenge is provided by dwarf galaxies, which are darker than what is expected in their innermost regions. These pieces of evidence can be more naturally explained, or sometimes even predicted, by modified theories of gravity, that do not introduce any dark fluid. I illustrate possible solutions to these problems with the modified theory of gravity MOND, which departs from Newtonian gravity for accelerations smaller than a0, and with Refracted Gravity, a novel classical theory of gravity introduced in 2016, where the modification of the law of gravity is instead regulated by a density scale.

Recent advancements in the structural biology of human telomerase and their implications for improved design of cancer therapeutics.

Telomerase is a specialized reverse transcriptase that synthesizes telomeric repeats at the ends of linear chromosomes. Telomerase is transiently expressed in germ and stem cells, but nearly all somatic cells silence it after differentiating. However, the vast majority of cancer cells reactivate and constitutively express telomerase to maintain replicative immortality. Because of this, telomerase has remained a promising broad-spectrum chemotherapeutic target for over 30 years. However, various challenges associated with obtaining high-resolution structural data for telomerase have limited the development of rationally designed structure-based therapeutics. Various techniques and model systems have been utilized to advance our understanding of the structural biology of telomerase. In particular, multiple high-resolution cryogenic electron microscopy (cryo-EM) structures published within the past few years have revealed new components of the telomerase complex with near atomic resolution structural models. Additionally, these structures have provided details for how telomerase is recruited to telomeres and its mechanism of telomere synthesis. With these new pieces of evidence, and the promising outlook for future refinements to our current models, the possibility of telomerase specific chemotherapeutics is becoming more tangible than ever. This review summarizes these recent advancements and outlines outstanding questions in the field.

Earth, wind and fire: Interactions between Quaternary environmental dynamics and human occupation on the southern coast of Brazil

The southern coast of Brazil has been settled in different episodes between ca. 7.5 and 0.5 ka before the present by hunter-fisher-gatherers, shell mound builders of the pre-colonial Sambaqui cultural tradition. The factors that influenced human migrations in these episodes are diverse. They include cultural changes due to the coming of other groups, chronic food shortages, sea level changes, and lagoon silting. This paper combines geological, geomorphological, meteorological, and archaeological data to show how interactions between environmental dynamics and human settlement played a central role in modeling coastal sedimentary and rocky landscapes on the southern coast of Brazil during the middle Pleistocene to late Holocene. On Costão do Ilhote, a north-south oriented granitic promontory in Laguna County, Santa Catarina State, erosional features such as facets, keels, grooves, flutes, pits, and polished surfaces that developed on granitic boulders and pavements were recognized as ventifacts. In the same context, hundreds of fixed sharpeners/polishers from the production of polished objects by the sambaqui culture have been found crosscutting the ventifacts. Based on crosscut relationships between pre-colonial aged fixed sharpeners/polishers and ventifacts, relative sea-level changes during the Holocene, the age of distinct generation of sand dunes, and the age of shellmounds (sambaquis), four potential intervals of ventifaction are proposed: last 650 ka, last 350 ka, between ca. 115 and 5 ka BP, and between ca. 2.0 and ∼0.5 ka BP, with separated estimated abrasion rates of approximately 3.5 × 10−5 mm/yr, 7.0 × 10−5 mm/yr, 1.7 × 10−4 mm/yr, and 1.3 × 10−2 mm/yr, respectively. The ca. ∼1.5 ka of the last ventifaction interval was synchronous with a period of sambaqui culture retreat in the southern coastal plain of Santa Catarina, and also coincided with a period of abundant sand availability. This period is characterized by a drastic decline in sambaquis construction along the sand barrier and paleolagoon and a migration towards lagoonal and coastal rocky promontories, including Costão do llhote. Based on these pieces of evidence, we propose to add new components to the close interactions between environmental evolution and prehistoric human occupation on the southern coast of Santa Catarina during the Holocene: the strong winds combined with sand availability.

The old evidence problem and the inference to the best explanation

The Problem of Old Evidence (POE) states that Bayesian confirmation theory cannot explain why a theory H can be confirmed by a piece of evidence E already known. Different dimensions of POE have been highlighted. Here, I consider the dynamic and static dimension. In the former, we want to explain how the discovery that H accounts for E confirms H. In the latter, we want to understand why E is and will be a reason to prefer H over its competitors. The aim of the paper is twofold. Firstly, I stress that two recent solutions to the dynamic dimension, recently proposed by Eva and Hartmann, can be read in terms of Inference to the Best Explanation (IBE). On this base, I gauge the weaknesses and strengths of the two models. Namely, I show that the two authors endorse a particular IBE’s formulation, and that it is still unsure if it is the one descriptively used. Moreover, I contend that, while one condition of their first model is not expression of this formulation, the only condition of their second model is. Secondly, I focus on the static dimension of POE which, now, has to be expressed in IBE terms. To solve it, I rely on the counterfactual approach, and on a version of IBE in which explanatory considerations help to evaluate the terms in Bayes’ theorem. However, it turns out that the problems of the counterfactual approach recur even when it is used to solve the static POE in IBE terms.

Exploring the Politics of Crime Control: An Emphasis on Liberian Society

This study explored the politics of crime control as its conceptual framework. It uses the qualitative method with particular emphasis on content analysis. The data collection was sourced from a relevant literature review comprised of articles, books, journals, and webpages. Putting Liberia in context, the study explains why certain crimes that make major news headlines or stories remain hanging without a logical conclusion for prosecution despite the quantum of evidence that may exist or be available. It attributes the reason to the interest of the state or government. It argues that regardless of the quantum of evidence or pieces of evidence that may be available, the protection of the state interest is more important than the outcome of the prosecution. Thus, the study found that as it relates to certain crimes that make major news headlines or stories the decision for prosecution is politically motivated in which the interest of the state or government must be protected at the expense of society’s expectations that override the prosecution of crime. The study concludes that the politics of crime control inherently promotes injustice. It violates the legal maxim “Let justice be done to all” or “No one is above the law”. This is because when pieces of evidence are ignored because of the interest of the state, or government, it denies people or victims of their rights to justice.

Nilotinib: from animal-based studies to clinical investigation in Alzheimer's disease patients.

Nilotinib: from animal-based studies to clinical investigation in Alzheimer's disease patients.

The Representation and Politicization of the Covid-19 Pandemic on the Front Pages of the Daily Newspapers of Russia, Italy, the United Kingdom, Spain, France, Portugal, Germany, and the United States

The impact COVID-19 has demanded an additional effort from the media to report a virus of global reach. During the lockdown, there has been an increase in information consumption derived from the interest and concern of citizens to know the characteristics, development, and threats of the coronavirus. Although social networks have ranked first among the cyberspace platforms most consulted by citizens, different studies indicate that citizens consider newspapers and magazines to have ‘good intentions’ compared to the ‘worst intentions’ of cyber-media and websites. Based on this, the research focuses on the covers of the paper editions of the newspapers, conceived as a fundamental element that synthesizes and hierarchizes the content that each medium considers of greatest importance and that is connected to the digital version of each medium. This research presents a comparative study of the newspaper covers of eight countries in the world (Italy, United Kingdom, Spain, France, Portugal, United States, Russia, and Germany) to analyze the number of news items about the pandemic, the type of text, the typology of information sources, the characters, the use of color, the inclusion and the focus of the photographs or the location on the page, among other parameters. The study analyzes 288 front pages of 16 daily newspapers (2 per country) in the world, collecting 1,478 news items that include 710 pieces of news, and 94,592 pieces of evidence using a mixed method of direct observation and hemerographic analysis. As a result, the few mentions of affected people and health personnel in front page information is evident, as is the predominance of news journalistic genres (brief and news, especially), and the political figures as the most represented actors shows a high degree of politicization of the global crisis. Finally, it is observed that the visual frames in the analyzed newspapers tend to promote humanization through emotional representation.

Mathematical modelling and analysis of COVID-19 and tuberculosis transmission dynamics

In this paper, a mathematical model for assessing the impact of COVID-19 on tuberculosis disease is proposed and analysed. There are pieces of evidence that patients with Tuberculosis (TB) have more chances of developing the SARS-CoV-2 infection. The mathematical model is qualitatively and quantitatively analysed by using the theory of stability analysis. The dynamic system shows endemic equilibrium point which is stable when R0<1 and unstable when R0>1. The global stability of the endemic point is analysed by constructing the Lyapunov function. The dynamic stability also exhibits bifurcation behaviour. The optimal control theory is used to find an optimal solution to the problem in the mathematical model. The sensitivity analysis is performed to clarify the effective parameters which affect the reproduction number the most. Numerical simulation is carried out to assess the effect of various biological parameters in the dynamic of both tuberculosis and COVID-19 classes. Our simulation results show that the COVID-19 and TB infections can be mitigated by controlling the transmission rate γ.

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The given article is dedicated to the main problem of assessment regarding the admissibility of evidence obtained as a result of an unlawful arrest. The essence of the connection between the causality related to such pieces of evidence and arresting facts was studied in the given article. The issues on the admissibility of the evidence have been discussed, obtained not only as a result of a non-lawful arrest but also by violation within the process of arrest. Foreign experience regarding the admissibility of such kind of evidence is presented.

PS-C13-9: BLOOD PRESSURE CONTROL AND THE LEFT VENTRICULAR ECHOCARDIOGRAPHIC PROGRESSION IN HYPERTENSIVE PATIENTS: AN 18 MONTHS FOLLOW-UP STUDY

Objectives: The impact of blood pressure control on left ventricular (LV) geometry and function remains unclear. The present study was to assess whether BP control associated with conventional LV geometry and function indexes or global longitudinal strain (GLS) progression, and when the echocardiographic changes would occur in hypertensive patients. Methods and Results: A total of 62 participants (mean age 55.2 ± 11.5, male 71.0%) with uncontrolled hypertension were included in the longitudinal study. The follow-up study was performed at 6 months and 18 months, when echocardiographic measurements were performed and BP control was evaluated during the follow up period. At the 6- and 18-months examination, patients were divided into two groups: BP controlled group and uncontrolled group. Patients with BP uncontrolled group (n = 33) had higher LV mass index(P = 0.02), higher left atrial volume index (P = 0.01), worse GLS (P = 0.005) and GLS changes (P = 0.003) compared with BP controlled group (n = 29) at the end of 6 months follow-up period. Patients with BP uncontrolled group (n = 25) had higher LV mass index(P = 0.001), higher LV mass index changes(p = 0.01), higher relative wall thickness (P = 0.01), higher E/e’ (p = 0.046), worse GLS (P = 0.02) and GLS changes (P = 0.02) compared with BP controlled group (n = 24) at the end of 18 months follow-up period. GLS changes was associated with BP control (beta = 0.370, P = 0.004 at 6 months and beta = 1.531, P = 0.02 at 18 months) in stepwise multivariate regression analysis. LV mass index changes was associated with BP control (beta = 0.426, P = 0.003) at the end of 18 months in stepwise multivariate regression analysis. Conclusions: Our findings offer a new piece of evidence on the association of BP control with echocardiographic changes in hypertensive patients, especially support the view that GLS progression was superior to conventional LV geometry and function parameters, GLS changes were significant between BP controlled and uncontrolled patients even in 6 months follow-up period.

HIDDEN IN PLAIN SIGHT: OVERLOOKED EVIDENCE CONCERNING JAMES CROLL (1821–1890)

ABSTRACT Three new pieces of evidence concerning James Croll, the nineteenth century Scottish autodidact and climate change pioneer are revealed. These untold facets became apparent as a result of pursuing evidence further than might have seemed warranted, and comprise: (1) Croll’s short-lived attempt to become a publisher; (2) appointment to a janitorial position at Anderson’s University and Museum in Glasgow a year later than claimed by himself and repeated by subsequent commentators; (3) the enigma of why letters from Joseph Dalton Hooker to Croll were copied onto notepaper headed Montreal Cottage in Perth, Scotland (the town in which Croll lived), and the identification of John Bower, a retired fleet-surgeon and friend of Croll, as the copyist. It is argued that the findings were hidden in plain sight, are not trivial, and shed light on the biography of a relatively neglected individual.

Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis.

Podocytes are essential components of the glomerular filtration barrier and essential for the proper filtration function of the glomerulus. Podocyte injury under various stress conditions is the primary pathogenesis and key determinant of focal segmental glomerulosclerosis (FSGS) with prominent clinical manifestations of proteinuria or nephrotic syndrome. Under physiological conditions, a highly coordinated mitochondrial quality control system, including antioxidant defenses, mitochondrial dynamics (fusion, fission, and mitophagy), and mitochondrial biogenesis, guarantees the sophisticated structure and various functions of podocytes. However, under FSGS pathological conditions, mitochondria encounter oxidative stress, dynamics disturbances, and defective mitochondrial biogenesis. Moreover, mutations in mitochondrial DNA and mitochondria-related genes are also strongly associated with FSGS. Based on these pieces of evidence, bioactive agents that function to relieve mitochondrial oxidative stress and promote mitochondrial biogenesis have been proven effective in preclinical FSGS models. Targeting the mitochondrial network is expected to provide new therapeutic strategies for the treatment of FSGS and delay its progression to end-stage renal disease. Mitochondrial dysfunction plays a key role in podocyte injury and FSGS progression. This review summarized recent advances in the study of mitochondrial homeostatic imbalance and dysfunction in FSGS and discussed the potential of mitochondria-targeted therapeutics in improving FSGS and retarding its progression to end-stage renal disease.