BackgroundSimulation plays a pivotal role in the design of enhanced oil recovery (EOR) processes based on reservoir and in-situ fluid conditions. A robust compositional model, using a complicated multi-component nanoemulsion injection fluid, was developed to describe the performance of nanoemulsion flooding to predict their feasibility for pilot oilfield projects. MethodGemini surfactant/polymer/nanoparticle stabilized Pickering nanoemulsions were prepared by high-energy method and characterized to assess core-flooding performance. During simulation, a Cartesian grid model with fixed bulk volume, injection flow rate, well completion parameters and rock-fluid properties was employed. Core-flooding experiments were performed in steps, involving ~2.16 pore volume (PV) brine injection, ~0.90 PV nanoemulsion injection and ~1.50 PV chase water injection. Significant findingsOil saturation map and relative permeability data analyses showed that the wetting nature of sandstone core altered from intermediate-wet to strongly water-wet condition. Tertiary recoveries were obtained in the range of 21-27% of the original oil in place (OOIP) for different surfactant/polymer/nanoparticle (SPN) compositions of injected nanoemulsion fluids. Flooding simulation studies showed good history matching of production data within ± 6% between experimental and simulated results. In summary, the efficacy of SPN nanoemulsions as an EOR fluid was corroborated with the aid of numerical simulation analyses.