Brief Biosketch Prof. Hamid Mobasheri did his PhD from the University of East Anglia, Norwich, UK. Further, he did his postdoc at the University of East Anglia with Welcome Trust Fellowship and later joined in the University of Tehran as Assistant Professor and subsequently become Professor of Biophysics at the same University. He is also a Co-founder of Center of Neural Repair, University of Tehran and Founder and member of Biomaterial Research Center (BRC), University of Tehran. Professor Mobasheri is also a Coordinator under UNESCO Chair-Life Sciences. His area of research is on - Biophysical programming of stem cells The outbreak of the SARS-COV-2 virus from Wuhan, China, in December 2019 caused a devastating pandemic and killing thousands of people worldwide. Unfortunately, the implication of various biological and chemical treatments including immunological, pharmaceutical, genetics and so on, had little curing effects. Despite vast efforts and the times invested, drug synthesis and vaccine production process take a long time and thus, alternative Biophysical means can be considered to overcome the problem effectively in a short time. Considering the atomic and molecular structure of the virus and the means of its interaction with target cells, it is obvious that all the interactions happening during the infection process have a root in physics of the involved molecules in the virus and cell. In other words virus binding, membrane fusion, engulfation, replication, release, etc. are all the consequences of different electrostatic interactions initiated at atomic levels. Electrostatic interactions are possible to be manipulated, interrupted and disrupted in a direct and fast manner through physicochemical treatments or application of external electric, magnetic and electromagnetic fields. Here, different biophysical approaches taken to detect, neutralize and destruct the virus will be discussed. The virus surface charges, charge distribution in spike protein both at the RBD site and main body as well as on ACE-2 receptor, their hydration status, ionic charges preset in the lung fluid, water in the vicinity of the mentioned molecules, the virus channel-forming protein ORF3a and membrane constitute lipids are all can be considered as the potential targets. It is possible to use these targets for detection, neutralization and destruction of the virus through biophysical treatment in a fast, cheap, direct and effective manner.