Physicochemical Properties Of Poly Research Articles

Targeted nano-drug delivery system for glioblastoma therapy: In vitro and in vivo study

This study developed polymeric nanoparticles (NPs) conjugated with monoclonal antibody (mAb) for glioblastoma treatment. In this study, the physicochemical properties of poly (butyl cyanoacrylate) (PBCA) NPs were characterized. The cytotoxicity of NPs conjugated with mAb (NPs + mAb) and in vitro drug release evaluation was tested on glioblastoma cell lines. Their therapeutic efficiency and side effects were then assessed in vivo in a rat model of glioblastoma. The conjugation of NPs to mAb revealed an average particle size of 365 nm and conjugation efficiency of 41.95%. The findings also showed that cytotoxicity was augmented by 40% compared to the free form of carboplatin. Moreover, in vivo studies showed that body weight remained relatively stable in rats treated by NPs + mAb and their survival time was longer (23.5 days) compared to rats treated with free carboplatin (19.5 days). In addition, ex vivo investigation showed that rats administered with NPs + mAb exhibited less side effects in the brain, kidney and liver compared to other groups.

Influence of selective laser sintering process parameters on microstructure and physicochemical properties of poly(vinyl alcohol) for the production of scaffolds

Purpose This study aims to investigate the production of scaffolds by selective laser sintering (SLS) using poly(vinyl alcohol) (PVA) polymer, for in vitro studies, a relatively new and growing area in which scaffolds could be used in the design of three-dimensional models for in vitro disease model or tissue equivalent for safety and effectiveness tests. Design/methodology/approach The influence of the SLS process parameters laser power, 26 W and 32 W, and number of laser scans, 1, 2, 4 and 6, on the surface microstructure of the samples and on the degree of crystallinity and chemical stability of PVA material, was investigated using powder with particle size of 20-320 µm. Laser sintered PVA samples were subjected to cell culture tests using osteoblastic cells derived from human osteosarcoma (SaOs-2). Findings The laser power has no significant influence on the microstructure of the laser-sintered samples, however the number of scans has a considerable influence on the sintering degree; the SLS process causes a decrease in the degree of crystallinity and changes the chemical structure of the as-received PVA, especially when using higher laser power and more number of scans. Preliminary in vitro cell culture tests show that the laser-sintered PVA material is biocompatible with SaOs-2 cells. Originality/value SLS offers good potential for the fabrication of scaffolds and thus, may be applied as an alternative to conventional scaffold fabrication processes to overcome their limitations.

Evaluation of multifunctional properties of gallic acid crosslinked Poly (vinyl alcohol)/Tragacanth Gum blend films for food packaging applications

The natural polymer Tragacanth Gum is less explored as a supporting matrix, there are very less studies conducted using this polymer in literature. So the present study aims to explore the consequences of different weight percent (wt.%) of gallic acid (GA) on physicochemical properties of Poly (vinyl alcohol)/Tragacanth Gum blend films. The incorporation of GA resulted in more strengthened but less flexible films as confirmed by tensile tests. DSC studies confirmed the miscibility of composite films in the given composition range and TGA studies revealed increased thermal stability. The morphological studies revealed a homogeneous distribution of GA at lower wt.% in the blend system. X-Ray Diffraction study depicted; the added GA lost crystalline structure after incorporating it into the blend. The Water Vapor Transmission Rate (WVTR) was improved after the incorporation of GA into the blend system. Overall migration studies revealed the limited release of GA from the matrix into food simulants. Soil degradation rate increased as the wt.% of GA increased. The composite films presented strong antioxidant activity; therefore, prepared composite films could be used as an alternative to current packaging materials.

Synthesis and physicochemical properties of poly[2‐(2‐chloro‐1‐methylbut‐2‐en‐1‐yl)aniline] obtained with various dopants

AbstractHighly soluble polyaniline was synthesized from a newly designed aniline derivative, namely 2‐[2‐chloro‐1‐methylbut‐2‐en‐1‐yl]aniline. The corresponding polyanilines, PClPA‐HA, PClPA‐SA, PClPA‐NA and PClPA‐PA, were characterized by means of 1H NMR, 13C NMR, high resolution mass spectroscopy, Fourier transform infrared spectroscopy, ultraviolet–visible spectroscopy and SEM images. The elemental analysis and electrical conductivity of the polymers are also presented. It is shown that the molecular weight of the polymers obtained depends on the method of synthesis. Spectroscopic studies confirmed the emeraldine form of the polyaniline derivatives. In the work, the dependence of the current passing through resistive structures based on thin poly[2‐(2‐chloro‐1‐methylbut‐2‐en‐1‐yl)aniline] films on the relative humidity of air was studied. The results of the studies showed the prospects of using thin polymer films in the design of chemical sensors. © 2020 Society of Chemical Industry

Elaboration of Charged Poly(Lactic-co-Glycolic Acid) Microparticles for Effective Release of Tranexamic Acid.

In this study, tranexamic acid (TA) was used as a model compound to study the charge effect on the physicochemical properties of poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs). Charged PLGA MPs were elaborated by the incorporation of a quaternary ammonium, cetyltrimethylammonium bromide (CTAB), during the double emulsion solvent evaporation process. Three TA-CTAB-carrying modes of PLGA MPs were designed in the CTAB-free (TA-MP), adsorption (TA-CTABAD), or encapsulation (TA-CTABEN) form. The obtained MPs were characterized by morphology and TA-MP affinity. The experiment revealed that the three prepared MPs were spherical and smooth, with pores on their surfaces. TA-CTABAD had a relatively narrow size distribution, compared with that of TA-MP and TA-CTABEN. The particle sizes of TA-MP, TA-CTABEN, TA-CTABAD were measured as 59 ± 17, 54 ± 20, and 19 ± 8 μm, respectively. The zeta potential of the three MPs was found to be in the order: TA-CTABAD > TA-CTABEN > TA-MP. Differential scanning calorimetry (DSC) indicated that the manufacturing process had no influence on the glass transition temperature of the MPs, which was close to 48 °C. Thermogravimetric analysis illustrated that the presence of CTAB slightly changed the thermal stability of PLGA MPs. In vitro release showed that TA-CTABAD exhibited faster TA release than TA-MP and TA-CTABEN in a basic environment (pH of 13), probably because of electrostatic attraction. At pH = 1, the release of TA from TA-CTABEN was faster than those from TA-MP and TA-CTABAD, probably because of electrostatic repulsion. However, the effect of electrostatic interaction was not significant at pH = 7.4.

Influence of Polyphosphates on the Physicochemical Properties of Poly (Vinyl Chloride) after Irradiation with Ultraviolet Light.

Three new polyphosphates were synthesized in good yields by reacting diethylenetriamine with the appropriate phosphate ester in ethanol under acidic conditions. The polyphosphate structures were determined using FT-IR and 1H-NMR spectroscopies, and their elemental compositions were confirmed by EDX spectroscopy. Polyphosphates were added to poly(vinyl chloride) (PVC) at low concentrations to fabricate thin films. The PVC films were irradiated with ultraviolet light for long periods, and the effect of polyphosphates as the photostabilizer was investigated by determining changes in the infrared spectra (intensity of specific functional group peaks), reduction in molecular weight, weight loss, and surface morphology. Minimal changes were seen for PVC films containing polyphosphate compared to that for the blank film. In addition, optical, scanning electron, and atomic force microscopies were used to inspect the surface morphology of films. Undesirable changes due to photodegradation were negligible in PVC films containing additives compared to films containing no additives. In addition, the surfaces were smoother and more homogeneous. Polyphosphates, and in particular ones that contain an ortho-geometry, act as efficient photostabilizers to reduce the rate of photodegradation. Polyphosphates absorb ultraviolet light, chelate with polymeric chains, scavenge radical moieties, and decompose peroxide residues.

Effect of Antibacterial Silver-Releasing Filler on the Physicochemical Properties of Poly(Methyl Methacrylate) Denture Base Material.

Colonization of polymeric dental prosthetic materials by yeast-like fungi and the association of these microorganisms with complications occurring during prosthetic treatment are important clinical problems. In previously presented research, submicron inorganic particles of silver sodium hydrogen zirconium phosphate (S–P) were introduced into poly(methyl methacrylate) (PMMA) denture base material which allowed for obtaining the antimicrobial effect during a 90 day experiment. The aim of the present study was to investigate the flexural strength, impact strength, hardness, wear resistance, sorption, and solubility during three months of storage in distilled water. With increasing S–P concentration after 2 days of conditioning in distilled water, reduced values of flexural strength (107–72 MPa), impact strength (18.4–5.5 MPa) as well as enhanced solubility (0.95–1.49 µg/mm3) were registered, but they were at acceptable levels, and the sorption was stable. Favorable changes included increased hardness (198–238 MPa), flexural modulus (2.9–3.3 GPa), and decreased volume loss during wear test (2.9–0.2 mm3). The percentage changes of the analyzed properties during the 90 days of storage in distilled water were similar for all materials.

Synthesis and physico-chemical properties of poly(N-vinyl pyrrolidone)-based hydrogels with titania nanoparticles.

Poly(N-vinyl pyrrolidone) (PVP)-based hydrogels with titania nanoparticles (TN) were synthesized by the sol–gel method for the first time and were characterized in different states (native, freeze-dried, air-dried to constant weight and ground to powder, or swollen to constant weight in H2O or D2O) by various methods such as wide-angle and small-angle X-ray and neutron scattering, neutron spin-echo (NSE) spectroscopy, and scanning electron microscopy. The static (static polymer–polymer correlation length (mesh size), associates of cross-links and PVP microchains) and dynamic (polymer chain relaxation rate, hydrodynamic polymer–polymer correlation length) structural elements were determined. The incorporation of titania nanoparticles into PVP hydrogel slightly increases the size of structural inhomogeneities (an increase in the static and dynamic polymer–polymer correlation length, the formation of associates of cross-links and PVP chains). Titania nanoparticles have an impact on the microstructure of the composite hydrogel and form associates with sizes from 0.5 to 2 µm attached to PVP hydrogel pore walls. The PVP and TN/PVP hydrogels show a high degree of water swelling. Moreover, the presence of titania nanoparticles in TN/PVP increases the number of water adsorption cycles compared to PVP hydrogel. The high swelling degree, bacteria-resistant and antimicrobial properties against Staphylococcus aureus allow considering NT/PVP hydrogels for medical applications as wound coatings.

Tuning with Phosphorylcholine Grafts Improves the Physicochemical Properties of PLL/pDNA Nanoparticles at Neutral pH

The improvement of biological properties of polycations is a fundamental step to overcome their limitations as non-viral gene carriers. This work studied the effect of phosphorylcholine (PC) groups on the physicochemical properties of poly(L-lysine) (PLL)/pDNA nanoparticles. Phosphorylcholine-grafted PLL derivatives (PLL-PC) containing increasing proportions of PC were obtained by the reductive amination reaction with phosphoryl glyceraldehyde and characterized by 1H NMR, FTIR, and GPC measurements. The PLL-PC derivatives were used to prepare polyplexes with pDNA and their properties were evaluated by fluorescence, gel electrophoresis and dynamic light scattering (DLS) measurements. The PLL-PC derivatives were able to interact with pDNA at low N/P ratios in physiological pH to form stable polyplexes having lower zeta potentials, as evidenced by the gel electrophoresis and zeta potentials measurements. A degree of grafting of 10% increased the in vitro transfection efficiency of PLL and a degree of 20 mol% of PC groups provided colloidal stability in physiological saline solution at neutral pH. Overall, the PC-PLL derivatives exhibited improved physicochemical properties and have significant potential for further studies as non-viral gene transfer agents.

Poly(ethylene glycol)- block-poly(2-aminoethyl methacrylate hydrochloride)-Based Polyplexes as Serum-Tolerant Nanosystems for Enhanced Gene Delivery.

Incorporation of poly(ethylene glycol) (PEG) into polyplexes has been used as a promising approach to enhance their stability and reduce unwanted interactions with biomolecules. However, this strategy generally has a negative influence on cellular uptake and, consequently, on transfection of target cells. In this work, we explore the effect of PEGylation on biological and physicochemical properties of poly(2-aminoethyl methacrylate) (PAMA)-based polyplexes. For this purpose, different tailor-made PEG- b-PAMA block copolymers, and the respective homopolymers, were synthesized using the controlled/"living" radical polymerization method based on activators regenerated by electron transfer atom transfer radical polymerization. The obtained data show that PEG- b-PAMA-based polyplexes exhibited a much better transfection activity/cytotoxicity relationship than the corresponding non-PEGylated nanocarriers. The best formulation, prepared with the largest block copolymer (PEG45- b-PAMA168) at a 25:1 N/P ratio, presented a 350-fold higher transfection activity in the presence of serum than that obtained with polyplexes generated with the gold standard bPEI. This higher transfection activity was associated to an improved capability to overcome the intracellular barriers, namely the release from the endolysosomal pathway and the vector unpacking and consequent DNA release from the nanosystem inside cells. Moreover, these nanocarriers exhibit suitable physicochemical properties for gene delivery, namely reduced sizes, high DNA protection, and colloidal stability. Overall, these findings demonstrate the high potential of the PEG45- b-PAMA168 block copolymer as a gene delivery system.

Evaluation of the antimicrobial, antioxidant and physicochemical properties of Poly(Vinyl chloride) films containing quercetin and silver nanoparticles

This work provides details regarding the physicochemical, antimicrobial and antioxidant properties of poly(vinyl chloride) (PVC)-based films containing 0.4% quercetin and silver nanoparticles (AgNPs) at various concentrations levels. The incorporation of quercetin and AgNPs into the PVC matrix considerably affected the thermal, mechanical and optical properties of the films. Results obtained from the tensile stresgth test, demonstrated an improvement in the mechanical strength of the films after the incorporation of both quercetin and AgNPs. Moreover, an increase in AgNPs concentration increased the rigidity, as compared to control PVC film. Antimicrobial activity against food pathogens (Escherichia coli, Salmonella Typhimurium and Listeria monocytogenes) was evaluated by an antimicrobial barrier test. Results showed that the PVC-based films with quercetin and AgNPs proved to be highly effective to inhibiting bacterial growth. Therefore, these results indicate promising evidence to possibly aid in the prevention of microbial dissemination in foods. Additionally, films incorporated with quercetin and AgNPs expressed an antioxidant capacity when evaluated via the DPPH method. Among all of the films evaluated, the PVC-based films containing 0.4% quercetin and 1% AgNPs were flexible, exhibiting excellent UV-light barrier properties and for use with fatty foods, with the intent of reducing lipid oxidation and preventing food pathogen dissemination.

Surface decontamination in fuel manufacture plants by chelating solution of nanoparticles

Abstract A nanoparticles chelating solution was synthesized by copolymerization of acrylonitrile (AN) and methacrylic acid (MAA) by radiation induced polymerization technique using 17 kGy irradiation doses. A high copolymer yield was obtained by using 80/20% of AN/MAA and comonomer concentration of 50% (w/w) at a dose rate of 2.58 KGy/h. The resultant cyano group (–CN) of nano-poly(AN/MAA) was converted by chemical modification using hydroxylamine (NH2–OH) to an amidoxime group [–C(=NOH)NH2], which was then confirmed by Fourier transform infrared spectroscopy (FTIR). The physico-chemical properties of poly(AN/MAA) and amidoximated poly(AN/MAA) nanoparticles were studied by FTIR, transmission electron microscopy (TEM), dynamic light scattering (DLS) and thermal gravimetric analysis (TGA). The morphological analysis by TEM and DLS showed a spherical and uniform size of the amidoximated poly(AN/MAA) nanoparticles. TGA results indicated that the thermal stability of poly(AN/MAA) increased by the amidoximation process. The surface decontamination due to uranium was also investigated by the prepared chelating nanoparticles solution. A high purity germanium detector (HPGe) was used as a surface contamination detection tool. The results showed the presence of peaks at different energies, namely, 186.2 keV for Ra-226 (U-238) and 143.76 keV, 163.35 keV and 205.31 for U-235 before the decontamination process. The disappearance of these peaks after decontamination confirmed the applicability and efficiency of the nanoparticles solution in uranium surface decontamination.

The electrochemical behavior of poly 1-pyrenemethyl methacrylate binder and its effect on the interfacial chemistry of a silicon electrode

The physico-chemical properties of poly (1-pyrenemethyl methacrylate) (PPy) are presented with respect to its use as a binder in a Si composite anode for Li-ion batteries. PPy thin-films on Si(100) wafer and Cu model electrodes are shown to exhibit superior adhesion as compared to conventional polyvinylidene difluoride (PVdF) binder. Electrochemical testing of the model bi-layer PPy/Si(100) electrodes in a standard organic carbonate electrolyte reveal higher electrolyte reduction current and an overall irreversible cathodic charge consumption during initial cycling versus the uncoated Si electrode. The PPy thin-film is also shown to impede lithiation of the underlying Si. XAS, AFM, TGA and ATR-FTIR analysis indicated that PPy binder is both chemically and electrochemically stable in the cycling potential range however significant swelling is observed due to a selective uptake of diethyl carbonate (DEC) from the electrolyte. The increased concentration of DEC and depletion of ethylene carbonate (EC) at the Si/PPy interface leads to continuous decomposition of the electrolyte and results in non-passivating behavior of the Si(100)/PPy electrode as compared to pristine silicon. Consequently, PPy binder improves the mechanical integrity of composite Si anodes but it influences mass transport at the Si(100)/PPy interface and alters electrochemical response of silicon during cycling in an adverse manner.

Preparation and Characterization of Functionalized Polyaniline-Based Nanocomposite as an Antibacterial Agent

Polyaniline-co-phenylenediamine (PAn/PDA) nanocomposite has been prepared in the aqueous medium using sodium dodecyl benzene sulfonate (DBSNa) and hydroxypropylcellulose (HPC) as a surfactant. The tests used in this research to characterize the products were SEM, TEM, FTIR, UV–Visible and TGA for morphology, particle size, chemical structure and stability. The results confirm that the spherical nanocomposites (40–90 nm) were formed with high thermal stability. It is shown in the results that the physicochemical properties of poly(alkyl substituted anilines) are depended on the substituent groups that are bonded to N-position. The prepared nanocomposites were then tested for the antibacterial properties against three pathogenic strains. The antibacterial properties of nanocomposites were investigated by disk diffusion, minimum inhibitory concentration (MIC), minimum bactericidal concentrations (MBC), and bactericidal kinetic methods. The disk diffusion result indicated that the diameter of the inhibition zones of PAn/PDA–HPC nanocomposite was 9, 11, and 10 mm against E. coli, P. aeruginosa, and S. aureus respectively. It was found that the value of MIC of PAn/PDA–HPC nanocomposite against E. coli, P. aeruginosa and S. aureus were 2.5, 1.25 and 2.5 mg/mL respectively. The evaluation results revealed the PAn/PDA–HPC nanocomposite exhibited excellent inhibitory activity against both gram-negative and gram-positive bacteria.

Nanocomposite materials based on poly(vinyl chloride) and bovine serum albumin modified ZnO through ultrasonic irradiation as a green technique: Optical, thermal, mechanical and morphological properties

In this project, physicochemical properties of poly(vinyl chloride) (PVC) reinforced by ZnO nanoparticles (NPs) were studied. Firstly, ZnO NPs were modified with bovine serum albumin (BSA) as an organo-modifier and biocompatible substance through ultrasound irradiation as environmental friendly, low cost and rapid means. Nanocomposite (NC) films were prepared by loadings of various ratios of ZnO/BSA NPs (3, 6 and 9wt%) inside the PVC. Structural morphology and physical properties of the ZnO-BSA NPs and NC films were investigated via Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis (TGA), transmission electron microscopy and field emission scanning electron microscopy. According to the obtained information from the TGA, an increase in the thermal stability can be clearly observed. Also the results of contact angle analysis indicated with increasing percent of ZnO/BSA NPs into PVC the hydrophilic behaviors of NCs were increased.

The influence of bovine serum albumin-modified silica on the physicochemical properties of poly(vinyl alcohol) nanocomposites synthesized by ultrasonication technique

In this study, for the first time polymeric nanocomposite (NC) films of poly(vinyl alcohol)/SiO2@bovine serum albumin (PVA/SiO2@BSA) were synthesized by solution casting method under facile and fast method of sonication. In this regard, SiO2 nanoparticles (NPs) were modified by BSA, at room temperature by using phosphate buffer and ultrasonic-assisted method. Then, PVA/SiO2@BSA NCs were prepared by insertion of variant amount (3, 6 and 9wt%) of SiO2@BSA into the PVA matrix, under ultrasonic irradiation. The morphological traits of the NCs were surveyed by Fourier transform infrared spectroscopy, transmission electron microscopy, X-ray diffraction and field emission scanning electron microscopy. It was detected that NPs incorporation didn’t remarkably affect the crystallinity and morphology of the NCs. TEM images indicated that the inserted NPs have good diffusions in the PVA matrix, and their embedment in the matrix significantly upgraded its thermal, optical and mechanical behaviors. The tensile strength showed more than 2-fold increase and the thermal stability exhibited about 37% enhancement that was higher, in comparison with those of the similar NCs. This showed that the prepared NCs can have potential application in food packaging.∗∗∗

Study on physicochemical properties of poly(ester-urethane) derived from biodegradable poly(ε-caprolactone) and poly(butylene succinate) as soft segments

Novel biodegradable polyester-based polyurethanes were developed based on poly(e-caprolactone) diol (PCL diol) and poly(butylene succinate) diol (PBS diol) as the biodegradable soft segments (SS), and diisocyanate and 1,4-butanediol (BDO) as the hard segment (HS). The PBS diol ( $$ \overline{{M_{\text{n}} }} $$ = 2000 g/mol) was successfully synthesized by melt condensation. The PBS diol and polyurethane sheets were characterized for chemical structure using NMR and FTIR techniques. The effect of hard segments and diisocyanate type on thermo-mechanical properties and hydrolytic degradation were examined by means of tensile testing, TGA, DSC and DMTA. The stress–strain curves of PURs reached the high 715 % elongation at break, 32.5 MPa tensile strength, and 123.8 MPa Young’s modulus. Increased hard segment content increased the tensile properties, thermal resistance and T g, but the hydrolytic degradation rate decreased. The IPDI-based polyurethane gave lower tensile properties, T g and hydrolytic degradation rate, but higher thermal stability than the TDI-based polyurethane.

Enhanced photocatalytic activity of TiO2 with poly(AA-DVB)

A composite material poly(AA-DVB)@TiO2, which exhibits high photocatalytic activity, was prepared using poly(AA-DVB) containing the electron-withdrawing group by a sol–gel method without calcination. The physicochemical properties of poly(AA-DVB)@TiO2 were characterized by XRD, SEM, TEM, BET, EDS, and XPS. Photocatalytic measurements were conducted using a xenon lamp with the aim of analyzing the degradation of methyl blue (MB) and methyl orange (MO) solutions. For the photodegradation of MB and MO, poly(AA-DVB)@TiO2 exhibits photocatalytic activity significantly higher than that of TiO2 solid nanocrystals. After five cycle experiments, poly(AA-DVB)@TiO2 exhibits better efficiency. The experiments confirmed that the aromatic rings and carboxyl groups, which lead to the negative conjugation effect, synergistic effect, and higher separation efficiency of photogenerated electrons and holes, can greatly improve the photocatalytic activity of TiO2. Light capture results indicate that the main catalytic factor in poly(AA-DVB)@TiO2 as the photocatalyst is the holes. Further, the high surface area and pore also improve the photocatalytic efficiency.

The effect of solvent on the synthesis and physicochemical properties of poly(3,4-ethylenedioxypyrrole)

Poly(3,4-ethylenedioxypyrrole), PEDOP, is a versatile compound, which has attracted significant scientific interest in the recent years. The wide range of its actual and prospective applications underlines the need for a comprehensive study of this material and identification of factors, allowing the physicochemical properties of PEDOP and its derivatives to be tailored for specific purposes. In this paper, we present the results of our investigation of the physicochemical properties of PEDOP, involving electrochemical, spectroelectrochemical and microscopic analysis. The electrochemical synthesis of PEDOP was performed in solvents of varying polarity and protic/aprotic nature, i.e. H2O, CH3CN and CH2Cl2, by means of cyclic voltammetry. Raman spectroscopy was applied in order to investigate the chemical structure of PEDOP synthesised under varying conditions. ESR measurements allowed the observation of changes in spin concentration as a function of applied potential and analysis of the stability of formed radical anions. UV–vis spectroelectrochemistry was applied to determine the value of optical band gap of PEDOP. The surface morphology of fabricated PEDOP layers was investigated via scanning electron microscopy.

Synthesis and physicochemical properties of poly(perfluoro-2-trichloromethylisopropyl acrylate)

A new acrylic monomer derived from perfluoro-2-trichloromethylisopropanol was synthesized. Poly(perfluoro-2-trichloromethylisopropyl acrylate) was prepared by radical bulk polymerization, and its physicochemical properties were studied. It was found that the prepared polyacrylate can be used to manufacture optical waveguides.