I thank the authors Giordano, Gravenstein, and Rice for their valuable comments on the subject of “Capnography Outside the Operating Rooms.”1 Due to the limitations of word count for “Clinical Concepts Commentary,” a detailed account of each capnogram was not provided. Given the wider scope of electronic accessibility, the intention of the article was to provide a comprehensive review of the use of capnography outside operating rooms not only to anesthesiologists and certified registered nurse anesthetists, but also to physicians in other specialties and nurses who provide sedation. Therefore, the article was scripted to provide a concise physiologic background and clinical applications of capnography.Giordano et al. raised important comments regarding capnograms 2C and 3A–D of the article.1 Analysis of capnograms 2C and 3A–D in the aforementioned article is a little more complex than the explanation provided by Giordano etal. Regarding 2C, they state that the inspiratory downstroke will sluggishly return to a zero baseline (or a β angle >90 degrees) during inspiratory valve malfunction. This may be true in the typical circumstance described by Giordano et al., where an assumption is made that half of the expiratory gases will enter the inspiratory limb. However in reality, the quantity of expiratory gases entering the inspiratory limb is dependent on the resistance to the flow of expiratory gases in each limb of the circuit. The resistance in turn is dependent on the design of the valves, extent of malfunction of the inspiratory valve, fresh gas flows, and the length of the circuit. In addition, the carbon dioxide concentration across the inspiratory limb is also dependent on turbulent versus laminar flow of expiratory gases and mixing of carbon dioxide–free fresh gases with expiratory gases in the inspiratory limb (expiratory gases do not flow in blocks). For example, if malfunction of the inspiratory valve results in decreased resistance, it is conceivable that more than half of the expiratory gases might enter the inspiratory limb. This, in conjunction with the gas mixing between carbon dioxide–containing expiratory gases and carbon dioxide–free fresh gases may cause the final portion of the inspiratory tidal volume to contain certain amounts of carbon dioxide. Thus, the resulting downstroke of the capnogram (phase 0) will not reach the zero baseline. This was illustrated by me and my colleagues in a case report where we recorded capnograms during inspiratory valve malfunction and the subsequent inspiratory downstrokes did not reach the baseline.2 However, it was also demonstrated by our group that capnograms can apparently appear normal despite substantial rebreathing resulting from inspiratory valve malfunction. However, when respiratory gas flows were superimposed on the capnograms, the significant rebreathing was obvious.3Regarding capnogram 3A–D illustrated in the original article,1 the morphology of capnograms depends, once again, on several factors. These include patient’s respiratory rate, tidal volume, supplementary oxygen flow, gas leaks from the mask resulting in the carbon dioxide washout by the oxygen flow, and more importantly, the site of the carbon dioxide sampling. In capnograms 3A–D, the site of the sampling was adjacent to the inside wall of the mask via an adaptor, and not at the nostril. Therefore, the recorded carbon dioxide concentration does not represent the carbon dioxide concentration at the nostril. The morphology of the capnograms depends on the location of carbon dioxide sampling within the mask and on the washout of carbon dioxide by the supplementary oxygen flow. Unless carbon dioxide measurements are performed at the nostril, it may be difficult to ascertain whether there is rebreathing (although minimal). For example, figure 1A and B from this reply shows a patient undergoing upper gastroinstestinal endoscopy with supplementary oxygen provided via the mask, and end-tidal carbon dioxide monitoring was performed within the nostril using carbon dioxide sampling nasal cannula. The endoscope was inserted via a “U-shaped flap cut” in the mask. In this case, the carbon dioxide rebreathing was zero (fig. 1B) due to the carbon dioxide washout by supplementary oxygen at the nostril. Capnograms during sedation is a good subject for future discussion.
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