This study focused on burnout among pediatric resident physicians in Central Visayas, exploring its association with various factors and coping strategies. The research objectives aimed to describe the socio-demographic profiles of respondents, assess burnout levels, analyze psychological distress, examine associations between socio-demographic factors and burnout/psychological distress, and identify burnout factors and coping strategies. The study utilized a cross-sectional design involving 80 pediatric residents, using the Maslach Burnout Inventory, Patient Health Questionnaire, and self-assessment questions. The analysis included mean, standard deviation, chi-square, and Fisher’s exact tests to explore associations and predictors of burnout. The findings revealed no incidence of burnout but indicated moderate emotional exhaustion, high depersonalization, and high personal accomplishment. The majority had experienced burnout in previous residency years. The top burnout factors were co-residents, conflicts, and consultants, while coping strategies included stress eating, exercise, and vacation leave. Psychological distress ranged from mild to severe, with anxiety and depression prevalent among certain groups. The study suggests the need for work-life balance training to address burnout incidents, particularly in developing economies like the Philippines. This recommendation aims to support the well-being of pediatric residents and improve their work-life balance.