JAMES R. SORENSON Boston University School of Medicine Doctor-patient exchanges in routinized medicine tend to exhibit relatively high professional control and corollary high patient dependency. This power dependency arrangement is to some extent based on bothfact andfaith; thefact that the physician has some expertise and the faith that the physician's actions will have the desired results in this specific situation. A number offactors can alter this arrangement, however. For example, biomedical innovations often produce more than routine uncertaintyfor the physician in clinical practice, resulting at times in a reduction in professional control and correspondingly an increase in the potential discretionary power of the patient. While some patients may readily accept an increase in their role as health decision-maker, many attempt to have the doctor exercise as much discretionary power in novel as in more routinized medical situations. As a result, one finds in developing areas of medicine a multiplicity of negotiated doctor-patient exchanges, some approximating traditional doctor-patient interaction and others exhibiting more of a collegial decision-making structure. One rapidly developing area of medicine, clinical genetics, is examined with particular attention given to types of doctor-patient