Background : Transgender people have managed to survive in a culture that does not accept them. Transgender people frequently experience racism, prejudice, physical harm threats, and violent acts. In order to guarantee that this group has access to basic services and combat prejudice and harassment, there is still a long way to go. Objective : The primary objective of this study was to compare and assess the perceived stress, loneliness, quality of life & emotional maturity in urban and rural area. Method :A sample of 50 transgender people, aged between 24 and 45, was taken, including 25 from rural areas and 25 from urban areas. The Perceived Stress Scale (PSS), UCLA Loneliness Scale, WHOQOL-BREF Scale, and Emotional Maturity Scale were the tools utilised to gather the data. Results : In results t-value is calculated and significant differences can be found among rural and urban transgenders regrading variables studied in the present paper. Conclusion : It's concluded that rural transgenders have higher stress, higher loneliness, low quality of life and higher emotional maturity compared to urban transgenders.