Relevance. Factors that can trigger binge eating episodes include mental and physical stress. Our studies show that maternal deprivation in early ontogenesis causes an increase in elements of gambling addiction in the Iowa Gambling Task test. The question arises about the significance of maternal deprivation in the formation of other types of non-chemical addictions, in particular food addiction. Target. The role of ghrelin in the manifestation of elements of bindge eating in rats exposed to maternal weaning in early ontogenesis was studied. Material and method. Animals were separated from their mother for 180 minutes from days 2 to 12 after birth; males aged 90-100 days were used in the experiments. When developingbindge eating, the animals received a diet high in carbohydrates (chocolate mixture based on Nutella spread) for 1 hour every third day for 1.5 months. 15 min before feeding, chocolate paste was placed within 5 cm of reach with visual contact.After developingbindge eating, we studied the number and area of ghrelin-producing neuroendocrine cells of the hypothalamus in intact rats and animals after maternal deprivation stressusing immunohistochemistry method. Results. Intermittent consumption of a chocolate mixture has been shown to predict binge eating in rats independent of weight gain or obesity, which is a manifestation of binge eating disorder. When studying the effect of maternal deprivation on chocolate consumption, it was shown that the average daily consumption in the maternal deprivation group increased (p0.001) relative to the control group. When studying the effect of maternal deprivation on the consumption of standard food, it was shown that consumption in the maternal deprivation group did not change relative to the control group. The number and area of ghrelin-producing neuroendocrine cells in the lateral portion of the medial arcuate nucleus of the hypothalamus decreased in rats after maternal deprivation. Conclusion. It was concluded that early psychogenic stress of maternal deprivation causes an imbalance of the ghrelin regulatory system with elements of food addiction in rats.