Physical Methods Research Articles

Optimization of the Domain Size in Stressed Liquid Crystals

The distributions of orientational and translational order parameters in liquid crystal polymer composites are studied using the methods of molecular-statistical physics. A model is considered in which the composite consists of liquid crystal (LC) domains separated by flat polymer sheets. The perturbation of the orientational and translational order parameters, which is caused by an arbitrary flat polymer sheet in a planar LC layer, is estimated. The effective distance over which this disturbance propagates is estimated. It is shown that it is proportional to the square root of the splay elastic constant of LC. It has been shown that in certain temperature ranges the polymer can induce a more ordered liquid crystal phase near itself (smectic phase inside of nematic phase and nematic phase – inside of isotropic liquid phase). In this case, the orientational order parameter of LC near the polymer can be significantly higher than far from it, and the “perturbation” of the order parameters can propagate over a distance of up to several micrometers with a sharp peak at a distance of the order of one micrometer. Based on the original theory, the methods have been proposed for optimizing the sizes of domains in stressed liquid crystals obtained by mechanical treatment in liquid crystal polymer composites.

Cobalt(II) phenylphenoxides as effective photocatalyst in the degradation of some organic dyes

Removal of toxic dyes by physical, biological and chemical methods have been carried out extensively, of which photochemical degradation, by coordination complexes in particular, has been found to be an effective treatment method owing to the use of natural sunlight as source of energy, resulting in no sludge formation along with the release of less toxic substances in the environment. In this study, synthesis and evaluation of photocatalytic activity of new cobalt(II) phenylphenoxides, 1–4, against some organic dyes viz. Malachite green, methyl orange, crystal violet, methylene blue and fuchsin basic have been studied. The complexes were characterized by physicochemical, 1H NMR, FTIR, high resolution mass spectra (HRMS), powder X-ray diffraction (PXRD) and electrochemical techniques. An attempt has been made to study the effect of varying experimental conditions like concentration of catalyst, nature of ligand, presence of initiator, on the degradation of dyes. Results have shown that the rate of degradation increases with increase in the concentration of catalyst in the presence of environment friendly initiator, hydrogen peroxide. Furthermore, the complexes were found to be more photo-catalytically active towards degradation of malachite green and methyl orange showing degradation of 89.7 % and 95 %, respectively, in the presence of initiator. The photocatalytic degradation of the dyes displayed pseudo first-order kinetics wherein the physical concept of dye degradation i.e. physiosorption governed the adsorption rate of particles onto the adsorbent. The complexes were found to act as effective photocatalyst as well as strong oxidant generator, HO·, carried out by photochemical decomposition of H2O2 under the effect of sunlight. Scavenging studies unveiled the active involvement of hydroxyl radicals (HO·) and electron vacancies (h+) in facilitating the degradation process. Notably, the complexes exhibited remarkable reusability, enduring up to 6 repeat cycles for methyl orange and 5 cycles for malachite green with significant degradation percentages which have revealed their potential role in the degradation of these dyes.

Methods of examination in physical therapy, and occupational therapy of people after stroke (clinical case)

the prognosis of recovery of patients after acute cerebrovascular accident depends on the type, severity, and area of brain damage. This article highlights standardized tests and scales for physical therapy and occupational therapy for patients after stroke. An example is given of a clinical case of a patient with stroke consequences, with right-sided spastic hemiplegia. Medical rehabilitation was provided in April 2023 at the Municipal Non-Profit Enterprise "Consultative and Diagnostic Center", branch №6, Sviatoshynskyi district, Kyiv, Department of Physical and Rehabilitation Medicine. After the patient visited the outpatient department of physical and rehabilitation medicine, the examination was conducted by the attending physician. A multidisciplinary team of a physical therapist and an occupational therapist was involved. An important step is the use of standardized tests and scales in physical therapy and occupational therapy. Based on the results of the examinations, the patient's goals are determined, and an individual rehabilitation program is built using evidence-based physical therapy and occupational therapy methods to provide a high-quality and effective rehabilitation cycle. Description of the objective. The standardized tests and scales in physical therapy, and occupational therapy are analyzed on the example of a clinical case of a patient after a stroke with right-sided spastic hemiplegia. Materials and methods. The clinician's handbook for 2020 on stroke rehabilitation was analyzed, with the justification of standardized tests and scales for physical therapy, and occupational therapy. A systematic review of the PubMed database was conducted, which included 44 scientific randomized trials and meta-analyses with accurate diagnoses of tests and scales for physical therapy and occupational therapy. The National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Scale (mRS) were used to assess stroke. Modified Ashworth Scale for the assessment of spastic muscles in patients with neurological disorders. To determine cognitive outcomes and complications after stroke: Montreal Outcome Cognitive Assessment (MOCA); Modified Barthel Index (BI); Line Drawing Test. For motor function: Fugl-Meyer Assessment (FMA); Chedoke Arm and Hand Activity Instrument (CAHAI). Berg Balance Assessment; Morse Fall Risk Test; Stand and Walk Test. Results. The results of the initial examination in physical therapy and occupational therapy determined the patient's functional and cognitive state, consequences, and limitations arising after a stroke. The intermediate examination summarizes the effectiveness of the selected rehabilitation measures. If the patient's results remain unchanged, the physical and occupational therapist changes the approach and methods to achieve the goals. The final examination analyzes the dynamics of restoration of impaired functions, and achievement of goals by the end of the rehabilitation cycle. Therefore, we used the patient's clinical case to compare the initial, intermediate, and final examinations. This allowed us to analyze the results and determine the effectiveness of the selected individual rehabilitation program. Conclusions. The main principle of providing quality rehabilitation measures is the examination in the clinical practice of a physical therapist, and occupational therapist, which is used to measure the goals and compare the results achieved.

Climate in the Treatment of Pulmonary Tuberculosis in the First Half 19th Century: The Case of Frederic Chopin

Abstract Background The famous Polish composer Frederic Chopin (1810–1849) suffered almost all his short life from pulmonary tuberculosis. Physical treatment and climate therapy are the only aspect of Chopin’s disease history that has not yet been thoroughly studied. The etiology of tuberculosis in Chopin’s time was not yet known, so physical means and changes in climate in the first half of the 19th century were the most important part of the physicians’ therapeutic arsenal in the treatment of pulmonary tuberculosis. Objectives are to study the use of physical methods and climate therapy in the treatment of Frederic Chopin. Methods Scopus, WoS, MedLine, and PubMed data-bases, electronic archives were searched without time restriction for information on the use of physical methods and climate therapy in the treatment of pulmonary tuberculosis in the first half of the 19th century in Europe. The analysis was also made of Chopin’s letters and the work of his most respected biographers in order to identify information about physical therapy in his treatment. Results Chopin’s disease had been actively progressing since 1835. According to the proper 19th-century tuberculosis treatment plan which was set out in the treatises of prominent European physicians, Chopin was treated with physical means: blister plasters, cupping, creosote inhalations, sulfur baths, opium and belladonna plasters. Changing the climate in winter (southern France or Italy) was also a standard recommendation. In October 1838, Chopin, who was still recovering from another seasonal exacerbation of pulmonary tuberculosis, took a trip to Mallorca, where he spent the winter. Conclusions Chopin had the advanced stage of consumption, which was already regarded at that time as a contraindication to climate change. The destination was also unsuitable for patients with pulmonary tuberculosis: winter climate of Majorca, characterized by high humidity and strong winds, negatively affected Chopin’s health. The disease was manifested by fever, hemoptysis, shortness of breath and exhaustion, which indicated tuberculosis intoxication and destruction of lung tissue. Chopin’s trip to Majorca 1838/1839 will forever go down in the history of climate therapy as an example of the negative consequences of ignoring contraindications to climate change.

Green synthesis of silver nanoparticles using Houttuynia cordata Thunb rhizome extracts and their antibacterial potential against common foodborne pathogens

SummaryThe biological synthesis of functionalised nanoparticles using plant materials is considered more cost‐effective and eco‐friendly than chemical and physical methods. Hence, this study demonstrated the synthesis of silver nanoparticles (AgNPs) using Houttuynia cordata Thunb rhizome (HCR). The extract, prepared with distilled water, provided the required phytochemical components, such as flavonoids, terpenoids, phenols, proteins and other essential bio‐reducing agents. The AgNPs were exposed to reaction conditions, such as temperatures, pH values and AgNO3 concentrations, to identify the optimum synthesis condition and explore their impacts on particle size and antibacterial action against Gram‐positive (Staphylococcus aureus) and Gram‐negative (Salmonella enterica and Shigella dysenteriae) foodborne pathogens. The formation of AgNPs was indicated by specific surface plasmon resonance (SPR) intensity at 440–450 nm and colour changes under different reaction conditions. The structure and size distribution characterised by SEM and TEM revealed that the AgNPs exhibited a spherical‐shaped structure with irregular contours, regular distribution and aggregation. Although the average particle size ranged from 2 to 100 nm, relatively smaller sizes were detected at 10 mM (54.30), 80 °C (49.50 nm) and pH 6 (60.16 nm) conditions. The FTIR spectrum and EDX spectral signals affirmed the presence of reducing and stabilising agents in HCR extract, following the reduction of AgNPs from Ag+ to Ag0. AgNPs also exhibited excellent antibacterial activity against S. aureus, S. enterica and Sh. dysenteriae, indicating a broad spectrum for various applications in the food and pharmaceutical industries.

Interacting quantum trajectories for particles with spin 1/2

In recent decades, the de Broglie-Bohm or ‘pilot wave’ interpretation of quantum mechanics–especially its concept of the ‘quantum trajectory’–has inspired a plethora of computational methods in molecular and chemical physics. One particularly promising subclass of such methods are the ‘interacting quantum trajectory’ (IQT) methods, for which an ensemble of trajectories is propagated independently of–and without any recourse to–an underlying wavefunction. In this work, an IQT version of the Pauli equation is developed–enabling spin to be incorporated into IQT theories for the first time, to the authors' knowledge. The new trajectory-based dynamical equations are then used to solve two iconic quantum problems involving spin: the ‘quantum spin flipper’, and the Stern-Gerlach experiment.

Manganese Nanoparticles: Synthesis, Mechanisms of Influence on Plant Resistance to Stress, and Prospects for Application in Agricultural Chemistry.

Manganese (Mn) is an important microelement for the mineral nutrition of plants, but it is not effectively absorbed from the soil and mineral salts added thereto and can also be toxic in high concentrations. Mn nanoparticles (NPs) are less toxic, more effective, and economical than Mn salts due to their nanosize. This article critically reviews the current publications on Mn NPs, focusing on their effects on plant health, growth, and stress tolerance, and explaining possible mechanisms of their effects. This review also provides basic information and examples of chemical, physical, and ecological ("green") methods for the synthesis of Mn NPs. It has been shown that the protective effect of Mn NPs is associated with their antioxidant activity, activation of systemic acquired resistance (SAR), and pronounced antimicrobial activity against phytopathogens. In conclusion, Mn NPs are promising agents for agriculture, but their effects on gene expression and plant microbiome require further research.

Comparison of CO2 absorption via terrestrial plants and microalgae: A review

Currently, global warming and climate change continue to increase along with CO2 gas emissions. This has an impact on the survival of organisms, including humans. Therefore, efforts to reduce CO2 emissions have been conducted by various methods, such as chemical, physical and biological methods, one of the most efficient methods to absorb CO2 gas is to use microalgae. Microalgae are photosynthetic organisms capable of absorbing CO2. Microalgae can also be converted into valuable products such as biofuels, biofertilizers, food, feed, medicines, and cosmetics through an integrated biorefinery concept. In the future, CO2 mitigation using microalgae will be massively studied, considering the many benefits obtained from the utilization of microalgae to reduce CO2 emissions in the world. Through the concept of biorefinery, microalgae can be processed into various derivative products that are useful for humans in the food, feed, health, industrial, medicine, and cosmetic sectors. This review will compare the effectiveness of CO2 absorption through terrestrial plants, microalgae, and microalgae-bacterial consortia to the possibility of its application and challenges.

Biological Control and Habitat Management for the Control of Onion Thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae), in Onion Production in Quebec, Canada.

Onion thrips (Thrips tabaci) can pose a significant threat to onion crops, causing leaf damage, reduced bulb size and quality, and yield loss during severe infestations. Conventional insecticide use has been the primary method for managing this pest species, but the efficacy of this approach is inconsistent. Furthermore, emerging pest resistance is a growing concern in some regions. This two-year field study aimed to assess the effectiveness of several pest management strategies in controlling onion thrips populations and limiting their impact on onion yields. The strategies tested consisted of habitat manipulations (including flower strips and straw mulch), biological control agents (Stratiolaelaps scimitus, Neoseiulus cucumeris, Amblyseius swirskii, and Beauveria bassiana), as well as physical barrier control methods (exclusion nets, kaolin, and mineral oil). Habitat manipulation techniques, particularly the use of flower strips, reduced thrips populations by up to 50% and increased onion yields by 25%. In contrast, exclusion nets had a detrimental effect on onion yields, and the other alternative control methods produced results comparable to those obtained for untreated controls. When used alone, biological control agents were not effective at maintaining thrips populations below economically damaging levels. This study offers valuable insights into effective and sustainable pest management practices for the onion industry.

Advances in hydrogen storage materials: harnessing innovative technology, from machine learning to computational chemistry, for energy storage solutions

The demand for clean and sustainable energy solutions is escalating as the global population grows and economies develop. Fossil fuels, which currently dominate the energy sector, contribute to greenhouse gas emissions and environmental degradation. In response to these challenges, hydrogen storage technologies have emerged as a promising avenue for achieving energy sustainability. This review provides an overview of recent advancements in hydrogen storage materials and technologies, emphasizing the importance of efficient storage for maximizing hydrogen's potential. The review highlights physical storage methods such as compressed hydrogen (reaching pressures of up to 70 MPa) and material-based approaches utilizing metal hydrides and carbon-containing substances. It also explores design considerations, computational chemistry, high-throughput screening, and machine-learning techniques employed in developing efficient hydrogen storage materials. This comprehensive analysis showcases the potential of hydrogen storage in addressing energy demands, reducing greenhouse gas emissions, and driving clean energy innovation.

Uncertainties in physical and tracer methods in actual groundwater recharge estimation in the thick loess deposits of China

Groundwater recharge (GR) can be estimated with physical, tracer techniques and numerical modelling; however, the uncertainties in these methods have not been fully interpreted. This study selected six methods for actual GR estimation in the saturated zones with different data requirements and method assumptions, including two physical methods (i.e., water table fluctuation WTF and Darcy's law DL) and four tracer techniques (i.e., chloride mass balance CMB, tritium renewal rate TRR, chlorofluorocarbons CFC and 14C dating method CBD). Taking the loess tablelands of China as an example study area, we first analyzed the uncertainties in these methods and then recommended the appropriate methods for GR estimation in regions with thick vadose zones. Overall, the recharge rates from WTF, CMB and CFC (88 ± 24, 98 ± 33 and 53 ± 9 mm/year) were much greater than those from DL, TRR and CBD (10 ± 3, 14 ± 3 and 7 ± 5 mm/year). The differences in estimated GR are closely related to the method parameters, assumptions and temporal scales. Specifically, the model parameters (e.g., specific yield, hydraulic conductivity) exhibit large ranges due to spatiotemporal heterogeneity, and the physical methods are more sensitive to hydrogeological parameters compared with the tracer techniques. The uncertainties related to model assumptions originate from the simplified water/solute movement processes. The lag effect of the thick vadose zone largely limits WTF and TRR, but contributes to CMB. Ignoring the mixing and dispersion effect may overestimate recharge by 36–48 % for CFC, and the heterogeneity of the aquifer reduces the potential of CBD for recharge estimation. Overall, CMB is considered as the most optimal method for estimating GR in the thick loess deposits. This study deepens the understanding of the uncertainties in GR assessment methods in regions with thick vadose zones.

Opportunities, Challenges, and Strategies for Scalable Deposition of Metal Halide Perovskite Solar Cells and Modules

Hybrid organic‐inorganic perovskite solar cells (PSCs) have rapidly advanced in the new generation of photovoltaic devices. As the demand for energy continues to grow, the pursuit of more stable, highly efficient, and cost‐effective solar cells has intensified in both academic research and the industry. Consequently, the development of scalable fabrication techniques that yield a uniform and dense perovskite absorber layer with optimal crystallization plays a crucial role to enhance stability and higher efficiency of perovskite solar modules. This review provides a comprehensive summary of recent advancements, comparison, and future prospects of scalable deposition techniques for perovskite photovoltaics. We discuss various techniques, including solution‐based and physical methods such as blade coating, inkjet printing (IJP), screen printing, slot‐die coating, physical vapor deposition, and spray coating that have been employed for fabrication of perovskite modules. The advantages and challenges associated with these techniques, such as contactless and maskless deposition, scalability, and compatibility with roll‐to‐roll processes, have been thoroughly examined. Finally, the integration of multiple subcells in perovskite solar modules is explored using different scalable deposition techniques.

Improving technology for disinfecting grain from pests of bread stock using ultra-high radiation frequencies

The article is devoted to the study of baking properties of flour made from microwave disinfected grain. The article also discusses methods that can assess the quality and safety of grain products. Measures taken for disinfestation of grain storage facilities are complex, expensive and require a complete shutdown of production, so it is relevant to search for new approaches to disinfestation of grain storage facilities without complete suspension of the work process. In this regard, methods of grain disinfestation using microwave radiation, electric fields and other physical methods that do not require stopping production are of considerable interest. The results of studies have shown that the use of microwave irradiation with high-frequency electromagnetic fields significantly increases the efficiency of destruction of pests in grain. The analysis of the effect of microwave irradiation on moisture, gluten content and temperature of grain indicates that the use of electromagnetic fields with a power of 180 W for 120-160 seconds does not affect the physical and chemical characteristics of grain. According to organoleptic evaluations, at optimal treatment parameters (180 W/m2 for 120-160 seconds) the color, aroma and taste of grain remain unchanged.

Halofuginone-guided nano-local therapy: Nano-thermosensitive hydrogels for postoperative metastatic canine mammary carcinoma with scar removal

In female dogs, the highest morbidity and mortality rates cancer are the result of mammary adenocarcinoma, which presents with metastases in the lung. Other than early surgical removal, however, no special methods are available to treat mammary adenocarcinoma. Because human breast cancer and canine mammary carcinoma share clinical characteristics and heterogeneity, the canine model is a suitable spontaneous tumor model for breast cancer in humans. In this study, the physical swelling method was used to prepare halofuginone-loaded D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) polymer micelles nano-thermosensitive hydrogels (HTPM-gel). Furthermore, HTPM-gel was investigated via characterization, morphology, properties such as swelling experiment and in vitro release with reflecting its splendid nature. Moreover, HTPM-gel was further examined its capability to anti-proliferation, anti-migration, and anti-invasion. Ultimately, HTPM-gel was investigated for its in vivo anticancer activity in the post-operative metastatic and angiogenic canine mammary carcinoma. HTPM-gel presented spherical under transmission electron microscope (TEM) and represented grid structure under scanning electron microscope (SEM), with hydrodynamic diameter (HD) of 20.25 ± 2.5 nm and zeta potential (ZP) of 15.10 ± 1.82 mV. Additionally, HTPM-gel own excellent properties comprised of pH-dependent swelling behavior, sustained release behavior. To impede the migration, invasion, and proliferation of CMT-U27 cells, we tested the efficacy of HTPM-gel. Evaluation of in vivo anti-tumor efficacy demonstrates HTPM-gel exhibit a splendid anti-metastasis and anti-angiogenic ability, with exhibiting ideal biocompatibility. Notably, HTPM-gel also inhibited the scar formation in the healing process after surgery. In summary, HTPM-gel exhibited anti-metastasis and anti-angiogenic and scar repair features. According to the results of this study, HTPM-gel has encouraging clinical potential to treat tumors with multifunctional hydrogel.

Dissolved Iron and Organic Matter in Boreal Rivers across a South–North Transect

Iron (Fe) is one of the main nutrients present in dissolved, suspended, and colloidal states in river water. Predicting the composition and size of dissolved Fe compounds is crucial for assessing water quality. In this stud, we used a combination of physical methods (filtration), chemical techniques (ion exchange chromatography), and thermodynamic modeling (Visual MINTEQ) to characterize dissolved Fe speciation in boreal organic-rich rivers across a sizable south–north transect. We chose contrasting rivers with a predominance of either allochthonous or autochthonous organic compounds. We found that the dissolved organic matter (DOM) in the studied rivers varies in molecular weights and the degree of humification. Regardless of the climate parameters of the river watershed, the dominant status of dissolved Fe during the summer low-water period was essentially colloidal and dominated by anionic complexes of the type [MeL]n−.

Chemical, Physical, and Biological Corneal Decellularization Methods: A Review of Literature.

The cornea is one of the most commonly transplanted tissues worldwide. It is used to restore vision when severe visual impairment or blindness occurs in patients with corneal diseases or after trauma. Due to the global shortage of healthy donor corneas, decellularized corneal tissue has significant potential as an alternative to corneal transplantation. It preserves the native and biological ultrastructure of the cornea and, therefore, represents the most promising scaffold. This article discusses different methods of corneal decellularization based on the current literature. We searched PubMed.gov for articles from January 2009 to December 2023 using the following keywords: corneal decellularization, decellularization methods, and corneal transplantation. Although several methods of decellularization of corneal tissue have been reported, a universal standardised protocol of corneal decellularization has not yet been introduced. In general, a combination of decellularization methods has been used for efficient decellularization while preserving the optimal properties of the corneal tissue.

The Impact of Sports Games on the Psychological Health of Middle School Students

This study conducted a 16-week comparative experiment with 160 students from Jinan No. 5 Middle School in Shandong Province as the experimental subjects. During the implementation of the experiment, the subjects were divided into two groups: an experimental group and a control group. The experimental group was subjected to physical exercise interventions using sports game teaching methods during physical education class, while the control group followed traditional physical education teaching methods. The results showed that the psychological health status of the students in the experimental group was significantly better than that of the control group after the experiment. The application of sports games helps to improve the psychological health of middle school students in the course of physical education, promoting a positive and forward direction in student psychology and is an effective means to enhance the psychological health level of middle school students.

Corrosion inhibition performance of new Schiff base cyclohexanamine derivatives on C-steel in 1 M HCl solution: Electrochemical, chemical, surface and computational explorations

Iron has many advantages, which makes it a material of great importance on the industrial level, but it is quickly affected by surrounding environmental factors that cause its corrosion. In this context, two new Schiff base cyclohexanamine derivatives (CSBs) were synthesized, characterized, and screened as corrosion inhibitors of C-steel in a 1 M hydrochloric acid solution. Specifically, they are (Z)-N-cyclohexyl-1-phenylethan-1-imine (CSB-1) and (E)-N′-cyclohexyl-N-hydroxybenzimidamide (CSB-2). 1H NMR was used to determine the structures of the new CSB molecules. The inhibition efficacies (%IE) were evaluated by combining theoretical, physical, chemical, electrochemical, and spectroscopic methods. The results confirmed that CSBs were mixed-type inhibitors and that the IE depended linearly on their concentration. The adsorption of these molecules on the metal surface is key to this role. Kinetic and thermodynamic studies indicated that they are physically adsorbed and subject the Langmuir adsorption isotherm. Using 0.001 M of inhibitor, the maximum %IEs achieved were 91.1 % for CSB-1 and 94.4 % for CSB-2, respectively, which confirms tatehat they are promising inhibitors. Surface analysis via atomic force microscopy (AFM) confirmed that the C-steel was covered in a protective layer. Several thermodynamic and kinetic parameters were calculated. DFT and Mullikan charge calculations and molecular dynamics (MD) simulations were applied to predict the effectiveness and interactions of new CSBs on the steel surface as well. Theoretical expectations correspond to the practical.

Surface modification of hollow gold nanoparticles conducted by incorporating cancer cell membrane and AS1411 aptamer, aiming to achieve a dual-targeted therapy for colorectal cancer

Due to its inherent membrane structure, a nanostructure enveloped by an active cell membrane possesses distinctive characteristics such as prolonged presence in the bloodstream, precise identification capabilities, and evasion of immune responses. This research involved the production of biomimetic nanoparticles, specifically hollow gold nanoparticles (HGNPs) loaded with methotrexate (MTX), which were further coated with cancer cell membrane. These nanoparticles were then adorned with AS1411 aptamer to serve as a targeting agent (Apt-CCM-HG@MTX). The nanoplatform demonstrated precise targeting towards cancer cells due to its dual-targeting characteristic (AS1411 aptamer and C26 cancer cell membrane), exhibiting uniformity in distribution. It also displayed a desirable response to photothermal stimulation, controlled release of drugs, and exceptional properties for fluorescence imaging. The system was composed of spherical HGNPs measuring 51.33 ± 5.70 nm in diameter, which were effectively loaded with MTX using a physical absorption method. The encapsulation efficiency achieved was recorded at 79.54 %, while the loading efficiency reached 38.21 %. The targeted formulation demonstrated a noteworthy mortality of approximately 45 % in the nucleolin positive cell line, C26, as determined by in vitro cytotoxicity assays. As a result of the functionalization process applied to the homologous binding adhesion molecules found in cancer cell membranes and targeting ability of AS1411 aptamer, Apt-CCM-HG@MTX demonstrated a substantial enhancement in targeting tumors and facilitating cellular uptake during in vivo experiments. Furthermore, under NIR radiation the photothermal effect exhibited by Apt-CCM-HG@MTX in the tumor area was notably robust due to the distinctive attributes of HGNPs. The conclusions obtained from this study have the potential to assist in adopting a bioinspired strategy that will significantly improve the effective management of MTX and therapy for individuals with colorectal cancer.

Online Voting System

Having a democratic voting system in place is crucial for any nation due to the general distrust of the conventional voting system. Individuals have seen the infringement of their basic rights. Lack of transparency has been a problem with several electronic voting methods. The government has a hard time winning the confidence of its citizens since most voting processes aren't transparent enough. It is easy to abuse, which is why both the old and new digital voting systems have failed. Finding solutions to issues with both the paper and electronic voting systems, such as voting-related injustices and accidents, is the main goal. A fair election with less injustice is possible with the use of blockchain technology integrated into the voting process. Both digital and physical voting methods have their limitations, making them unsuitable for widespread use. This evaluates the importance of finding a way to protect people's democratic rights. To foster confidence between voters and election officials, this article introduces a platform built on blockchain technology, which maximises system stability and transparency. Without the need for traditional polling places, the proposed technology lays the groundwork for digital voting using blockchain. A scalable blockchain may be supported by our suggested architecture via the use of adaptable consensus algorithms. The voting process is made more secure with the use of the Chain Security algorithm. When conducting a chain transaction, smart contracts provide a safe channel of communication between the user and the network. There has also been talk of the voting system's security being based on blockchain technology.