We apply the reduced phase space quantization to the Kasner universe. We construct the kinematical phase space, find solutions to the Hamilton equations of motion, identify Dirac observables and arrive at physical solutions in terms of Dirac observables and an internal clock. We obtain the physical Hilbert space, which is the carrier space of the self-adjoint representation of the Dirac observables. Then, we discuss the problem of time. We demonstrate that the inclusion of evolution in a gravitational system, at classical level as well as at quantum level, leads respectively to canonically and unitarily inequivalent theories. The example of Hubble operator in two different clock variables and with two distinct spectra is given.