Aquatic exercise is an active exercise that make full use of the physical and hydrodynamic characteristics of water in a water environment to achieve a similar strength increase effect as land training, while avoiding the aggravation of joint stress and muscle microdamage caused by repetitive training. It has been widely studied in the field of sports rehabilitation and public fitness, while its form is basically presented in the form of aerobic exercise or interval training, the aquatic resistance exercises are often ignored by people. Due to the influence of the physical characteristics of water, the main form of muscle contraction of athletes performing resistance training in water is similar to isokinetic contraction, and the force used by practitioners is proportional to the resistance of water, which increases the centrifugal load of muscles and greatly reduces the risk of sports injury. In addition to the athletes, aquatic resistance exercises also have certain benefits for other clinical diseases. In this paper, the application of this training in swimming performance, rheumatoid arthritis, postmenopausal osteoporosis and knee osteoarthritis was reviewed in order to improve the clinical understanding and promote its rational application.